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Significant associations were found for the single nucleotide polymorphism (SNP) ss1388116472 of the OXTR and any of the personality components.
Our findings suggest an association between genetic variation in OXTR and endorsement of prosocial behavior indirectly through prosocial tendencies, and that the pathway is dependent on the type of prosocial behavior and gender.
OXTR CpG methylation X child abuse interaction is associated with adult depression and anxiety.
The OXTR rs53576 genotype and attachment style are on social anxiety possibly constituting a targetable combined risk marker of social anxiety disorder.
The found of this study underscore a series of relations among a common oxytocin receptor gene variant, early life stress exposure, and structure and function of the amygdala in early life.
boys and girls of depressed mothers who carried the Oxytocin Receptor rs53576 GG genotype exhibited increased sensitivity for sad faces and decreased sensitivity for happy faces.
estimation of the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations
In this study, authors examine the association between the OXTR gene and a specific social phenotype within ASD (show ARSD Proteins)
Mothers and GG allele carriers of the OXTR gene showed an early latency (~100 ms) differential frontal ERP response to strong intensity facial expressions, and mothers also showed modulation of the posterior EPN waveform by negative valence.
Data show that oxytocin receptor and estrogen receptor beta (show ESR2 Proteins) single nucleotide polymorphisms (SNPs) temper accelerated cellular aging in young females who tend to make impatient choices.
results indicate that the OXTR genotype affects attitudinal trust as part of an individual's relatively stable disposition, and further affects behavioral trust through changes in attitudinal trust.
Data suggest that the study might contribute to the monosynaptic analysis of neuronal circuits and to the optogenetic analysis of neurons expressing oxytocin receptor (OXTR).
Our results suggest that microglial abnormality is a potential mechanism of the development of Oxt (show OXT Proteins)/Oxtr mediated ASD (show GUSB Proteins)-like phenotypes.
The results suggest that oxytocin receptor is required for conditioned effects of an ethanol-associated social stimulus
This study identify highly specialized roles of lateral septal mGluR5 (show GRM5 Proteins) and Oxtr in the the regulation of discrete social behaviors, and suggest that deficits in social interactions.
OTR-null residents exhibited greater aggression toward intruders of the same strain compared to OTR wild-type or heterozygous residents
Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior
Oxtr signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Oxytocin conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning.
Study used the oxytocin analog Carbetocin and nucleus accumbens viral-mediated overexpression to assess the role of OxtR in the acquisition, extinction, and reinstatement of ethanol-induced conditioned place preference
Oxytocin's effect on osteoblast differentiation is mediated by and dependent on the internalization of Oxtrs and their translocation to the nucleus, facilitated by successive interactions with beta-arrestins, Rab5 (show RAB5A Proteins), Kpnb1 (show KPNB1 Proteins)), and Tnpo1 (show TNPO1 Proteins).
Silencing of interneurons that express the oxytocin receptor in the medial prefrontal cortex (mPFC) of female mice resulted in loss of social interest in male mice specifically during the sexually receptive phase of the estrous cycle.
relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle
Components of the interferon (show IFNA Proteins) system are found to significantly influence the transcription of the bovine oxytocin receptor gene.
the presence of oxytocin receptors (OTR) in oviductal tissues is evident in the follicular phase cow
These data show that E2 can stimulate PGF2 alpha secretion by increasing OXTR expression in bovine endometrial cells in vitro, but only after exposure to P4.
Oxytocin receptor down-regulation is not necessary for reducing oxytocin-induced prostaglandin F(2alpha) accumulation by interferon-tau in a bovine endometrial epithelial cell line.
Immunoreactive OTR was detected in primordial and growing primary follicles in the infantile ovary and in follicles at all stages of development in the adult ovary.
Oxytocin receptor binding in the female forebrain varied across the reproductive cycle.
cAMP, acting through a specific upstream CREB (show CREB1 Proteins) binding site, is critical for the physiological upregulation of OXTRs in the amnion at the end of gestation.
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.
, oxcytocin receptor
, endometrial oxytocin receptor
, oxytocin-like receptor
, rhodopsin family
, amnion oxytocin receptor