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anti-Human alpha Adducin Antibodies:
anti-Mouse (Murine) alpha Adducin Antibodies:
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Human Polyclonal alpha Adducin Primary Antibody for WB - ABIN2801956
Joshi, Gilligan, Otto, McLaughlin, Bennett: Primary structure and domain organization of human alpha and beta adducin. in The Journal of cell biology 1991
Show all 4 Pubmed References
The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with Essential Hypertension risk in a Caucasian population from Madeira Island.
ZNF322A (show ZNF322A Antibodies) overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis
ADD1 rs4963 polymorphism showed an increased hypertension risk.
This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus.
Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC (show CALR Antibodies)) suggesting an association between ADD1 and CRC (show CALR Antibodies) risk.
The T allele of ADD1 is associated with essential hypertension in Asians.
study of potential effects of interaction between DNA methylation (show HELLS Antibodies) of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation (show HELLS Antibodies) of ADD1 gene promoter have a significant role in modifying EH susceptibility
There were significant differences between the control group and pediatric hypertensive group in terms of ACE (show ACE Antibodies) I/D (P<0.05) and AGT (show AGXT Antibodies) M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.
A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
When alpha-adducin complexes with sodium potassium ATPase (show DNAH8 Antibodies) in astrocytes, non-cell autonomous neurodegeneration is triggered.
Reduction in ADD1 protein in NEK1 (show NEK1 Antibodies) mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 (show MYO10 Antibodies) during meiotic spindle formation
suggesting a specific effect of sterol regulatory element binding protein (show CNBP Antibodies)-1c on neurosteroidogenesis
Transforming growth factor-beta activated kinase 1 (TAK1 (show MAP3K7 Antibodies)) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (show FAM126A Antibodies)) development.
miR (show MLXIP Antibodies)-185 negatively regulates the differentiation of 3T3-L1 cells by targeting SREBP-1 (show SREBF1 Antibodies)
SREBP1 (show SREBF1 Antibodies) pathway plays an important role in hepatocellular carcinoma pathogenesis.
In hepatocytes, E4BP4 (show NFIL3 Antibodies) interacts with nuclear SREBP-1c (show SREBF1 Antibodies) to preserve its acetylation, and subsequently protects it from ubiquitination-dependent degradation
SREBP1 (show SREBF1 Antibodies) also contributes to the resolution phase of TLR4 (show TLR4 Antibodies)-induced gene activation by reprogramming macrophage lipid metabolism.
27OH is not an important regulator of Srebp- or LXR regulated genes under basal conditions in mouse liver
Collectively, these findings demonstrate that LXRalpha (show NR1H3 Antibodies) activation induces 17beta-HSD13 expression in a SREBP-1c (show SREBF1 Antibodies)-dependent manner.
These results demonstrate that HDAC3 and SCAP control symbiotic pathways of liver lipid metabolism that are critical for suppression of lipotoxicity.
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms\; however, not all variants have been fully described.
adducin 1 (alpha)
, adducin 2 (beta)
, erythrocyte adducin alpha subunit
, erythrocyte adducin subunit alpha
, adipocyte determination- and differentiation-dependent factor 1
, sterol regulatory element-binding protein 1