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anti-Human alpha Adducin Antibodies:
anti-Mouse (Murine) alpha Adducin Antibodies:
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Human Polyclonal alpha Adducin Primary Antibody for WB - ABIN2801956
Joshi, Gilligan, Otto, McLaughlin, Bennett: Primary structure and domain organization of human alpha and beta adducin. in The Journal of cell biology 1991
Show all 4 Pubmed References
The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with Essential Hypertension risk in a Caucasian population from Madeira Island.
ZNF322A (show ZNF322A Antibodies) overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis
ADD1 rs4963 polymorphism showed an increased hypertension risk.
This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus.
Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC (show CALR Antibodies)) suggesting an association between ADD1 and CRC (show CALR Antibodies) risk.
The T allele of ADD1 is associated with essential hypertension in Asians.
study of potential effects of interaction between DNA methylation (show HELLS Antibodies) of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation (show HELLS Antibodies) of ADD1 gene promoter have a significant role in modifying EH susceptibility
There were significant differences between the control group and pediatric hypertensive group in terms of ACE (show ACE Antibodies) I/D (P<0.05) and AGT (show AGXT Antibodies) M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.
A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
When alpha-adducin complexes with sodium potassium ATPase (show DNAH8 Antibodies) in astrocytes, non-cell autonomous neurodegeneration is triggered.
Data show that miR (show MLXIP Antibodies)-200b and miR (show MLXIP Antibodies)-200c could directly bind the 3' UTR (show UTS2R Antibodies) of JUN (show JUN Antibodies), and JUN (show JUN Antibodies) activated the transcription of srebp1 (show SREBF1 Antibodies) to increase lipid accumulation.
a novel role for SREBP-1 (show SREBF1 Antibodies) as a cell surface retention factor for TbetaRI (show TGFBR1 Antibodies) in mesangial cells, is reported.
Srebp1c (show SREBF1 Antibodies) is a key regulator of metabolic remodeling leading to the beneficial effects of caloric restriction.
The present study indicates a requirement for C/EBPbeta (show CEBPB Antibodies) in the insulin (show INS Antibodies)-mediated induction of SREBP-1c (show SREBF1 Antibodies) mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha (show NR1H3 Antibodies), our data reported herein indicate a requirement for both transcription factors.
Sez6l2 (show SEZ6L2 Antibodies) is one of the auxiliary subunits of the AMPA (show GRIA3 Antibodies) receptor and acts as a scaffolding protein to link GluR1 (show GRIA1 Antibodies) to ADD. Furthermore, Sez6l2 (show SEZ6L2 Antibodies) overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 (show SEZ6L2 Antibodies) modulates AMPA (show GRIA3 Antibodies)-ADD signal transduction.
The deletion of Srebf-2 (show SREBF2 Antibodies) and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR (show NR1H3 Antibodies) activity and SREBP-1c (show SREBF1 Antibodies) expression.
The fasting-induced transcription factor KLF15, a key regulator of gluconeogenesis, forms a complex with LXR (show NR1H3 Antibodies)/RXR, specifically on the Srebf1 (show TOM1L2 Antibodies) promoter.
Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 (show NFE2L2 Antibodies) recruitment to the Srebp-1c (show SREBF1 Antibodies) promoter in livers of BPA (show DST Antibodies)-exposed mice was observed.
Reduction in ADD1 protein in NEK1 (show NEK1 Antibodies) mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 (show MYO10 Antibodies) during meiotic spindle formation
suggesting a specific effect of sterol regulatory element binding protein (show CNBP Antibodies)-1c on neurosteroidogenesis
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms\; however, not all variants have been fully described.
adducin 1 (alpha)
, adducin 2 (beta)
, erythrocyte adducin alpha subunit
, erythrocyte adducin subunit alpha
, adipocyte determination- and differentiation-dependent factor 1
, sterol regulatory element-binding protein 1