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Human CHGA Protein expressed in Escherichia coli (E. coli) - ABIN667739
Montero-Hadjadje, Elias, Chevalier, Benard, Tanguy, Turquier, Galas, Yon, Malagon, Driouich, Gasman, Anouar: Chromogranin A promotes peptide hormone sorting to mobile granules in constitutively and regulated secreting cells: role of conserved N- and C-terminal peptides. in The Journal of biological chemistry 2009
Show all 2 references for ABIN667739
Study indicates that chga may play an important role in nervous system development during the early embryonic stages.
dilated mitochondrial cristae, endoplasmic reticulum and Golgi complex, as well as increased synaptic mitochondria, synaptic vesicles and glycogen (show GYS1 Proteins) granules in Chga-knockout mice compared to WT mice.
the presence of ChgA and subsequent activation of ChgA-reactive T cells are essential for the initiation and development of autoimmune diabetes in NOD mice.
Studied leptin (show LEP Proteins) and CST (show CORT Proteins) modulation of SGLT1 (show SLC5A1 Proteins) expression in hyperleptinemic type 2 diabetic mice.
N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide (show IAPP Proteins) precursor (IAPP (show IAPP Proteins)) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (show PRSS16 Proteins)).
the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Chromogranin A (10-19) and chromogranin A (43-52) were identified as antigens for autoreactive CD8 (show CD8A Proteins)(+) T cells in NOD.beta2m(null).HHD mice.
Report QT/heart rate variability in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension.
We probed the role of the chromogranin A-derived peptide pancreastatin (PST (show ST8SIA4 Proteins): CHGA(273-301)) by investigating the effect of diet-induced obesity (DIO) on insulin (show INS Proteins) sensitivity of these mice.
Findings indicate that peptides from the N-terminal region of chromogranin A (ChgA) are able to induce cellular and humoral immune responses in NOD mice.
Data suggest pancreastatin, a 49 residue post-translational fragment of chromogranin A, as a routinely tested biomarker in neuroendocrine tumors (NETs) and in particular small bowel NET.
Data indicate that measurement of chromogranin A (CgA) alone is sufficient in the management of patients with neuroendocrine tumours (NETs) and that routine additional measurement of chromogranin B (CgB (show CHGB Proteins)) provides little added value.
Data show that chrysin suppressed cell proliferation and reducing expression of achaete-scute complex-like 1 (ASCL1 (show ASCL1 Proteins)) and the neuroendocrine biomarker chromogranin A (CgA).
In a Japanese population, the Ser (show SIGLEC1 Proteins)-364 allele was associated with elevated systolic blood pressure and pulse pressure, consistent with increased arterial stiffness.
ChrA levels were not effective in predicting outcomes or detecting recurrences of Merkel cell carcinoma.
Decreased CSF (show CSF2 Proteins) levels of chromogranin A were found in Parkinson disease patients with orthostatic hypotension.
In both mice and men the Gly364Ser polymorphism conferred metabolic traits such as elevated HDL (show HSD11B1 Proteins) and lowered norepinephrine levels; it was associated with superior baroreflex function and therefore better response to stress.
In patients with resected pancreatic neuroendocrine tumors, an elevated preoperative CgA (show CGA Proteins) level was negatively associated with disease-free survival and overall survival.
In astrocytes from multiple sclerosis white matter lesions the expression of chromogranin A is increased.
Receiver operating characteristic analyses showed that ChgA autoantibodies are valuable in the predictive diagnosis of non-small cell lung cancer (NSCLC), suggesting that serum autoantibodies to ChgA-derived peptides are promising novel markers of NSCLC
High pancreastatin levels are significantly associated with neuroendocrine tumors.
No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring.
expression and localization of chromogranin A (CgA), chromogranin B (CgB (show CHGB Proteins)), synaptophysin (show SYP Proteins), and insulin (show INS Proteins) were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
Vasoconstriction-Inhibiting Factor (VIF (show BTG1 Proteins)), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor (show AGTR2 Proteins).
chromogranin A has a role in the IP(3)-mediated Ca(2 (show CA2 Proteins)+) release mechanism of secretory granules
chromogranin A has a specific site in the N-terminal domain that can bind membrane lipids from different species
role of coupling with the inositol 1,4,5-trisphosphate receptor/Ca2 (show CA2 Proteins)+ channel (InsP3R (show ITPR1 Proteins))in the Ca2 (show CA2 Proteins)+-dependent ciliary movement
involvement of CGA (show CGA Proteins) with other components of the senile plaque
significant species differences in vasoactivity of the N-terminal domain of ChgA
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2 (show CA2 Proteins)+) homeostasis in secretory cells
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides\; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
, chromogranin A
, betagranin (N-terminal fragment of chromogranin A)
, parathyroid secretory protein 1
, pituitary secretory protein I