Chromogranin A Protein (CHGA) (AA 457-717) (His tag)
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- Target See all Chromogranin A (CHGA) Proteins
- Chromogranin A (CHGA)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 457-717
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Chromogranin A protein is labelled with His tag.
- Sequence
- Ile457-Leu717
- Characteristics
- A DNA sequence encoding theMouse Chromogranin-A/Chga(P26339) (457Ile-717Leu) was expressed with a polyhistidine tag at the N-terminus.
- Purity
- >90 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CHGA Protein
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- Comment
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used as Immunogen for (ABIN6999910, ABIN7234262, ABIN7234263 and ABIN7234264)
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- Chromogranin A (CHGA)
- Alternative Name
- Chromogranin-A (CHGA Products)
- Synonyms
- CGA Protein, CG-ALPHA Protein, FSHA Protein, GPHA1 Protein, GPHa Protein, HCG Protein, LHA Protein, TSHA Protein, ChrA Protein, fj05f09 Protein, si:dkey-177p2.2 Protein, wu:fj05f09 Protein, zgc:101749 Protein, zgc:56075 Protein, CHGA Protein, cgA Protein, chga Protein, chromogranin A Protein, glycoprotein hormones, alpha polypeptide Protein, uncharacterized CHGA Protein, chromogranin A S homeolog Protein, CHGA Protein, CGA Protein, Chga Protein, chga Protein, chga.S Protein
- Background
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Background: Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation . Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress .
Synonym: beta Granin,betagranin (N-terminal fragment of chromogranin A),catestatin,CgA,CHG A,Chga,chromofungin,Chromogranin A,Chromogranin A parathyroid secretory protein 1,Chromogranin A precursor,ChromograninA,CMGA,ER-37,Pancreastatin,Parastatin,Parathyroid secretory protein 1,Pituitary secretory protein I,Secretory protein I,SP I,SP-I,SP1,SPI,Vasostatin,Vasostatin I,Vasostatin II
- Molecular Weight
- 31 kDa
- UniProt
- P26339
- Pathways
- Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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