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FS proteins may also function in facilitating ligand diffusion. We find that mutants of daw are rescued in significant numbers by expression of vertebrate follistatin (FS) proteins
The activin-A (show INHBA ELISA Kits) to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes.
Low follistatin expression is associated with liver cirrhosis.
Follistatin levels are associated with circulating leptin (show LEP ELISA Kits) levels and display a day-night rhythm and a menstrual cycle, but not a seasonal, variation.
Within the nonalcoholic fatty liver disease group of patients, follistatin was associated with steatohepatitis independently from activin A (show INHBA ELISA Kits)
annexin A2 (show ANXA2 ELISA Kits) but not follistatin is expressed in hepatocellular carcinoma
FST plays a role in tumourigenesis, metastasis and angiogenesis of solid tumours through its interaction with activin (show Actbeta ELISA Kits) and BMPs, thus resulting in pathophysiological function. In terms of diagnosis, prognosis and therapy, FST has shown strong promise
Study shows that INHBA (show INHBA ELISA Kits) and FST are induced by seminal fluid in cervical tissues and thus, may contribute to regulation of the post-coital response in women.
Circulating follistatin may be a marker of the glucagon (show GCG ELISA Kits)-to-insulin (show INS ELISA Kits) tone on the liver
We report here an original observation that activin-B (show Actbeta ELISA Kits) is upregulated in the human idiopathic pulmonary fibrosis lung.
changes in Follistatin levels during pregnancy contribute to the control of the activin A (show INHBA ELISA Kits) system
Response to selection for increased litter size could not be attributed to effects at the estrogen receptor (show ESR1 ELISA Kits), retinol-binding protein or follistatin loci.
Data suggest that SMAD4 (SMAD family member 4 (show SMAD4 ELISA Kits)) mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and then decreases; embryotrophic actions of FST are SMAD4 (show SMAD4 ELISA Kits) dependent.
The expression of the components of the activin (show Actbeta ELISA Kits)-inhibin-follistatin system is altered in bovine cystic ovarian disease.
A functional role for oocyte-derived follistatin in bovine early embryogenesis.
Results showed activin (show Actbeta ELISA Kits)-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin (show Actbeta ELISA Kits)-C. Study provides evidence to support a role of activin (show Actbeta ELISA Kits)-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.
Oviducts of tghFST315 mice failed to coil, the myometrium was disorganised, endometrial gland number was reduced and oviducts and uteri contained abundant leukocytes. These studies show that follistatin is crucial to postnatal oviductal-uterine development and function.
OVOL1 (show OVOL1 ELISA Kits)-regulated Fst and SFRP1 (show SFRP1 ELISA Kits) affect hair inductive potency of neonatal dermal cells.
This study assesses the regulation of activin A (show INHBA ELISA Kits) and follistatin in a murine myocardial ischaemia-reperfusion model.
Results implicate a role of follistatin (Fst) in the induction of brown adipocyte character and regulation of energy metabolism.
follistatin induces hair wave propagation and its level decreases in aging mice.
Follistatin aids in maintaining proper somite size, and consequently sclerotome progenitor numbers, by preventing paraxial mesoderm from adopting an intermediate/lateral plate mesodermal fate in the Noggin (show NOG ELISA Kits)-deficient state.
Report role of activin A (show INHBA ELISA Kits)-myostatin (show MSTN ELISA Kits)-follistatin system on aging bone and muscle progenitor cells.
Data from transgenic mice suggest that overexpression of follistatin negatively influences bone metabolism decreasing all measured biomechanical strength parameters in developing bone.
These data indicate that the rapid increase in circulating activin A (show INHBA ELISA Kits) during LPS (show TLR4 ELISA Kits)-induced inflammation is regulated at the posttranscriptional level.
Roles of follistatin 1 in regulation of zebrafish fecundity and sexual differentiation.
Results suggest that Follistatin 1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.
Follistatin increased with growth of ovary. Increased significantly during vitellogenesis. Gradually increased during daily ovulatory cycle.
fst, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
, follistatin 1
, activin-binding protein
, follistatin isoform FST317
, follistatin A