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|Antigen||Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) Antibodies|
|Conjugate||This NTRK3 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|2 references available|
|Supplier||Log in to see|
Product Details anti-NTRK3 AntibodyTarget Details NTRK3 Application Details Handling References for anti-NTRK3 antibody (ABIN359954) Images
|Specificity||This antibody reacts to TRKC.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human TRKC.|
Target Details NTRK3Product Details anti-NTRK3 Antibody Application Details Handling References for anti-NTRK3 antibody (ABIN359954) Images back to top
|Alternative Name||TrkC (NTRK3 Antibody Abstract)|
|Background||TRKC, a member of the insuline receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3). Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.Synonyms: GP145-TrkC, NT-3 growth factor receptor, NTRK3, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase|
|Gene ID||4916, 9606|
|Pathways||RTK Signaling, Neurotrophin Signaling Pathway, Regulation of Cell Size|
Application DetailsProduct Details anti-NTRK3 Antibody Target Details NTRK3 Handling References for anti-NTRK3 antibody (ABIN359954) Images back to top
ELISA: 1/1,000. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NTRK3 Antibody Target Details NTRK3 Application Details References for anti-NTRK3 antibody (ABIN359954) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-NTRK3 antibody (ABIN359954)Product Details anti-NTRK3 Antibody Target Details NTRK3 Application Details Handling Images back to top
McGregor, Baylin, Griffin, Hawkins, Nelkin: "Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant." in: Genomics, Vol. 22, Issue 2, pp. 267-72, 1995
Shelton, Sutherland, Gripp, Camerato, Armanini, Phillips, Carroll, Spencer, Levinson: "Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 2, pp. 477-91, 1995
ImagesProduct Details anti-NTRK3 Antibody Target Details NTRK3 Application Details Handling References for anti-NTRK3 antibody (ABIN359954) back to top