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Browse our tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide Proteins (YWHAE)

Full name:
tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide Proteins (YWHAE)
On www.antibodies-online.com are 17 tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE) Proteins from 8 different suppliers available. Additionally we are shipping tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide Antibodies (76) and tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide Kits (23) and many more products for this protein. A total of 124 tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide products are currently listed.
Synonyms:
14-3-3, 14-3-3 epsilon, 14-3-3-e, 14-3-3-epsilon, 14-3-3E, 14-3-3epsilon, 14-3-3omicron, 14-3-30epsilon, 143E_DROME, 1433epsilon, ACYPI002517, anon-WO0172774.141, anon-WO02059370.52, AU019196, CG31196, CT24092, D14-3-3e, d14-3-3epsilon, Dmel\\CG31196, EK3-5, eps, fe38c12, KCIP-1, l(3)j2B10, LOC581376, MDCR, MDS, par-5, PAR5, SR3-9, Su(Raf)3B, wu:fb48f06, wu:fe38c12, wu:fi22e10, ywhae, zgc:55377, zgc:77062
list all proteins Gene Name GeneID UniProt
YWHAE 7531 P62258
YWHAE 22627 P62259
YWHAE 29753 P62260

Show all synonyms

tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide Proteins (YWHAE) by Origin

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Top referenced tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide Proteins

  1. Human YWHAE Protein expressed in Escherichia coli (E. coli) - ABIN2003477 : Aoki, Hayashi, Moriyama, Arakawa, Hino: Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. in Journal of virology 2000 (PubMed)
    Show all 4 references for ABIN2003477

  2. Mouse (Murine) YWHAE Protein expressed in Escherichia coli (E. coli) - ABIN2008168 : Gu, Jin, Choi, Baek, Yeo, Lee: Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. in FEBS letters 2006 (PubMed)
    Show all 4 references for ABIN2008168

  3. Human YWHAE Protein expressed in Escherichia coli (E. coli) - ABIN667700 : Oriente, Andreozzi, Romano, Perruolo, Perfetti, Fiory, Miele, Beguinot, Formisano: Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN667700

More Proteins for tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide Interaction Partners

Fruit Fly (Drosophila melanogaster) tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE) interaction partners

  1. The Khc73 stalk/14-3-3 (show YWHAZ Proteins)/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.

  2. role of 14-3-3epsilon in germ cell migration

  3. 14-3-3epsilon acts as a biochemical control point for axon guidance in Drosophila, silencing Plexin A repulsive axon guidance and regulating a semaphorin repulsion/integrin adhesion switch.

  4. We conclude that 14-3-3epsilon is required for Rab11 (show RAB11A Proteins)-positive vesicle function, which in turn enables antimicrobial peptide (show cAMP Proteins) secretion during an innate immune response.

  5. Hpo (show GFER Proteins) signaling inhibited Yki (show YAP1 Proteins) nuclear localization and activity by phosphorylating Yki (show YAP1 Proteins) and both isoforms of 14-3-3 (show YWHAZ Proteins), 14-3-3varepsilon and 14-3-3zeta (show YWHAZ Proteins), regulate Yki (show YAP1 Proteins) activity through modulating its subcellular localization.

  6. Drosophila 14-3-3/PAR-5 (show YWHAZ Proteins) is an essential mediator of PAR-1 (show F2R Proteins) function in axis formation.

  7. PAR-1 (show F2R Proteins) phosphorylates Bazooka/PAR-3 (show PARD3 Proteins) on two conserved serines to generate 14-3-3 (show YWHAZ Proteins) binding sites. This inhibits formation of the Bazooka (show PARD3 Proteins)/PAR-6 (show PARD6A Proteins)/aPKC complex by blocking Bazooka (show PARD3 Proteins) oligomerization and binding to aPKC.

  8. Serves as a central modulator of forkhead transcription factor FoxO activity in the regulation of growth, cell death and longevity in vivo.

Silk Worm tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE) interaction partners

  1. The expression of epsilon isoforms of 14-3-3 protein was identified at substantial levels in the first instar larva, upregulated in the second instar larva, and the highest levels were maintained in the late stage of larva, the pupa, and the adult.

Human tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE) interaction partners

  1. Studies show that patients with clear cell sarcoma of the kidney (CCSK) and the fusion YWHAE-NUTM2B/E were relatively young, had low tumor volumes, and did not present with stage I disease which fail to identify an explicit clinical phenotype.

  2. Data show that the NS3 protein of dengue virus bound to 14-3-3 epsilon protein (14-3-3varepsilon) and prevented translocation of retinoic acid-inducible gene-I protein (RIG-I (show DDX58 Proteins)) to the adaptor MAVS (show MAVS Proteins) protein and thereby blocked antiviral signaling.

  3. Report mutually exclusive BCOR (show BCOR Proteins) internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney.

  4. CEP131 is the key regulatory target of MK2 (show KCNA2 Proteins) and 14-3-3 (show YWHAQ Proteins) in centriolar satellite remodeling.

  5. 14-3-3epsilon might directly bind to CD13 (show ANPEP Proteins), which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis.

  6. DAPK2 (show DAPK2 Proteins)-induced apoptosis is negatively regulated by Akt (show AKT1 Proteins) and 14-3-3 (show YWHAQ Proteins) proteins.

  7. These data demonstrate a novel role for HDAC6 (show HDAC6 Proteins) in controlling 14-3-3zeta (show YWHAZ Proteins) binding activity.

  8. YWHAE-FAM22 rearrangement is associated with endometrial stromal sarcomas.

  9. Results suggest a specific role for YWHAE single nucleotide polymorphisms in the pathophysiology of schizophrenia.

  10. Cleft lip/palate has been found associated with 17p13.3 duplication involving a single candidate gene (YWHAE) in a father and his son.

Mouse (Murine) tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE) interaction partners

  1. 14-3-3epsilon might directly bind to CD13 (show ANPEP Proteins), which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis.

  2. Data indicate that 14-3-3epsilon is required for the mitotic entry in the fertilized mouse eggs and responsible for sequestering the CDC25B (show CDC25B Proteins) in cytoplasm. Its binding to CDC25B (show CDC25B Proteins)-S321 phosphorylated by PKA induces mitotic arrest.

  3. Ser321 of Cdc25B is the specific binding site for 14-3-3epsilon binding.

  4. 14-3-3epsilon deletion did not appear to induce compensation by other 14-3-3 (show YWHAQ Proteins) isoforms but led to ventricular noncompaction, resulting from a selective reduction in compact myocardium thickness.

  5. 14-3-3epsilon haploinsufficiency decreased the incorporation of expanded ATXN1 (show ATXN1 Proteins) into its large toxic complexes in the cerebellum but not in the brainstem, and the distribution of ATXN1 (show ATXN1 Proteins)'s small and large native complexes differed significantly between two regions

  6. 14-3-3 epsilon belongs to a regulatory protein family involved in important cellular processes, including those leading to neurodegenerative diseases, and thus its increased expression suggests a role of this protein in tuning microglia activation

  7. The finding of this study suggested that dysfunction of the TH neuronal network caused by the deficit of 14-3-3 epsilon may have been involved in the pathophysiology of schizophrenia and correlated with a dysfunction in the DISC1 (show DISC1 Proteins) complex.

  8. 14-3-3epsilon interacts directly with PDX-1 (show PDX1 Proteins) to regulate its cellular distribution in pancreatic beta cells.

  9. overexpression of 14-3-3epsilon led to resistance to both rotenone and 1-methyl-4-phenylpyridinium (MPP(+)), while other isoforms were not protective against both toxins.

  10. The appearance of 14-3-3 (show YWHAQ Proteins) proteins in the cerebrospinal fluid is characteristic of some neurodegenerative conditions

tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE) Protein Profile

Protein Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.

Alternative names and synonyms associated with tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, epsilon Polypeptide (YWHAE)

  • CG31196 gene product from transcript CG31196-RB (14-3-3epsilon)
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (ywhae)
  • 14-3-3 epsilon (LOC581376)
  • 14-3-3 epsilon protein (Ywhae)
  • 14-3-3 protein epsilon (HCAG_04173)
  • 14-3-3 protein epsilon (PTRG_02836)
  • 14-3-3 protein epsilon (PTRG_04459)
  • 14-3-3 protein epsilon (UREG_07864)
  • 14-3-3 protein epsilon (14-3-3epsilon)
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (YWHAE)
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (LOC100229976)
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (Ywhae)
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 (ywhae1)
  • 14-3-3 protein
  • 14-3-3 epsilon protein
  • 14-3-3-e protein
  • 14-3-3-epsilon protein
  • 14-3-3E protein
  • 14-3-3epsilon protein
  • 14-3-3omicron protein
  • 14-3-30epsilon protein
  • 143E_DROME protein
  • 1433epsilon protein
  • ACYPI002517 protein
  • anon-WO0172774.141 protein
  • anon-WO02059370.52 protein
  • AU019196 protein
  • CG31196 protein
  • CT24092 protein
  • D14-3-3e protein
  • d14-3-3epsilon protein
  • Dmel\\CG31196 protein
  • EK3-5 protein
  • eps protein
  • fe38c12 protein
  • KCIP-1 protein
  • l(3)j2B10 protein
  • LOC581376 protein
  • MDCR protein
  • MDS protein
  • par-5 protein
  • PAR5 protein
  • SR3-9 protein
  • Su(Raf)3B protein
  • wu:fb48f06 protein
  • wu:fe38c12 protein
  • wu:fi22e10 protein
  • ywhae protein
  • zgc:55377 protein
  • zgc:77062 protein

Protein level used designations for YWHAE

14-3-3&epsilon , 14-3-3e , 14-3-3epsilon-PA , 14-3-3epsilon-PB , 14-3-3epsilon-PC , 14-3-3epsilon-PD , CG31196-PA , CG31196-PB , CG31196-PC , CG31196-PD , Tyrosine-3-monooxygenase , epsilon , suppressor of Ras85D 3-9 , 14-3-3 epsilon , 14-3-3 epsilon protein , tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide , 14-3-3 protein epsilon , tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide , mitochondrial import stimulation factor L subunit , protein kinase C inhibitor protein-1 , tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide , 14-3-3E , tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide , MSF L , mitochondrial import stimulation factor (MSF) L subunit , tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide , 14-3-3 protein , 14-3-3epsilon

GENE ID SPECIES
42186 Drosophila melanogaster
493518 Xenopus (Silurana) tropicalis
581376 Strongylocentrotus purpuratus
778465 Bombyx mori
5446935 Ajellomyces capsulatus NAm1
6341059 Pyrenophora tritici-repentis Pt-1C-BFP
6342700 Pyrenophora tritici-repentis Pt-1C-BFP
8440315 Uncinocarpus reesii 1704
100161283 Acyrthosiphon pisum
454409 Pan troglodytes
721207 Macaca mulatta
100229976 Taeniopygia guttata
7531 Homo sapiens
22627 Mus musculus
29753 Rattus norvegicus
417554 Gallus gallus
282125 Bos taurus
443300 Ovis aries
380397 Xenopus laevis
480645 Canis lupus familiaris
322060 Danio rerio
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