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crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A
These results suggested that APN (show ANPEP ELISA Kits) ameliorated endothelial inflammation and IR through ROS (show ROS1 ELISA Kits)/IKKbeta pathway.
p300 (show EP300 ELISA Kits)-dependent histone H3 (show HIST3H3 ELISA Kits) acetylation and C/EBPbeta (show CEBPB ELISA Kits)-regulated IKKbeta expression contribute to thrombin (show F2 ELISA Kits)-induced IL-8/CXCL8 (show IL8 ELISA Kits) expression in human lung epithelial cells.
EGFR (show EGFR ELISA Kits)/PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits)/IKK-beta/NF-kappaB (show NFKB1 ELISA Kits) signaling promotes head and neck cancer progression.
our results illustrate a new direction in nitrosourea treatment, and reveal that the combination of ROS (show ROS1 ELISA Kits)-inducing IKKbeta inhibitors with nitrosoureas can be potentially exploited for melanoma therapy
Smad7 (show SMAD7 ELISA Kits) expression in necrotizing enterocolitis macrophages interrupts TGF-beta (show TGFB1 ELISA Kits) signaling and promotes NF-kappaB (show NFKB1 ELISA Kits)-mediated inflammatory signaling in these cells through increased expression of IKK-beta
High IKBKB expression is associated with prostate cancer.
Akt2 (show AKT2 ELISA Kits), Erk2 (show MAPK1 ELISA Kits), and IKK1 (show CHUK ELISA Kits)/2 phosphorylate Bcl3 (show BCL3 ELISA Kits), converting Bcl3 (show BCL3 ELISA Kits) into a transcriptional coregulator by facilitating its recruitment to DNA.
Rare variants in IKBKB are associated with decreased waist-to-hip ratio in European-Americans.
pVHL (show VHL ELISA Kits) mediates K63-linked ubiquitination of IKKbeta, which plays a role in the regulation of IKK (show CHUK ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signalling.
N-acetyl-seryl-aspartyl-lysyl-proline inhibition of TNF-alpha (show TNF ELISA Kits) activation of canonical, i.e., IKK-beta-dependent, NF-kappaB (show NFKB1 ELISA Kits) pathway and subsequent decrease in ICAM-1 (show ICAM1 ELISA Kits) expression is achieved via inhibition of IKK-beta.
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin (show PRL ELISA Kits) in bovine mammary epithelial cells.
Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin (show INS ELISA Kits)-mediated NO production.
High glucose-induced IKK (show CHUK ELISA Kits)-Hsp-90 (show HSP90 ELISA Kits) interaction contributes to endothelial dysfunction.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP (show GSTP1 ELISA Kits) significantly attenuated LPS (show TLR4 ELISA Kits)- or IKKbeta-induced production of GM-CSF (show CSF2 ELISA Kits). These studies indicate a complex role for GSTP (show GSTP1 ELISA Kits) in modulating NF-kappaB (show NFKB1 ELISA Kits), which may involve S-glutathionylation of IKK (show CHUK ELISA Kits) proteins, and interaction with NF-kappaB (show NFKB1 ELISA Kits) family members.
Myeloid ikkbeta gene deletion significantly reduced the percentage of CD4 (show CD4 ELISA Kits)(+)/IFN-gamma (show IFNG ELISA Kits)(+) (Th1 (show HAND1 ELISA Kits)) and CD4 (show CD4 ELISA Kits)(+)/IL-17 (show IL17A ELISA Kits)(+) (Th17) cells
Pharmacological and genetic inhibition of IKKbeta decreased voluntary ethanol consumption, providing initial support for IKKbeta as a potential therapeutic target for alcohol abuse.
Myeloid IKKbeta deficiency prevents Western diet-induced obesity and visceral adiposity in females but not in males, and attenuates hyperglycemia, global insulin (show INS ELISA Kits) resistance, and non-alcoholic steatohepatitis in both genders. In contrast, all metabolic sequela including non-alcoholic steatohepatitis are aggravated by hepatocyte IKKbeta deficiency (IkbkbDeltahep) in male but not female mice.
lymphocyte-specific deletion of IKK2 or NEMO (show IKBKG ELISA Kits) aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.
data clearly demonstrate that KLHL21 (show KLHL21 ELISA Kits) negatively regulates TNFalpha (show TNF ELISA Kits)-activated NF-kappaB (show NFKB1 ELISA Kits) signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB (show NFKB1 ELISA Kits) regulation in cells.
Study used three experimental approaches to enhance the IKKbeta activity in the liver of obese mice and observed increased XBP1s activity, reduced endoplasmic reticulum stress, and a significant improvement in insulin (show INS ELISA Kits) sensitivity and consequently in glucose homeostasis.
Mutation of cysteine 46 in IKK-beta increases inflammatory responses.
TAK1 (show NR2C2 ELISA Kits) and IKK2 are novel mediators of SCF (show KITLG ELISA Kits)-induced signaling and potential targets for c-Kit (show KIT ELISA Kits)-driven diseases.
MyD88s is positively regulated by IKKbeta and CREB (show CREB1 ELISA Kits) and negatively regulated by ERK1/2 (show MAPK1/3 ELISA Kits) signaling pathways.
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
, inhibitor of nuclear factor kappa-B kinase subunit beta
, inhibitor of nuclear factor kappa-B kinase subunit beta-like
, IKK-like protein
, LPS-responsive kinase
, cactus kinase
, deficient 5
, immune response
, lipopolysaccharide activated kinase
, mmune response deficient 5
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, nuclear factor NF-kappa-B inhibitor kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of kappa light chain gene enhancer in B cells, kinase beta