You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our IKBKB Proteins (IKBKB)

Full name:
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta Proteins (IKBKB)
On www.antibodies-online.com are 13 Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) Proteins from 8 different suppliers available. Additionally we are shipping IKBKB Antibodies (681) and IKBKB Kits (26) and many more products for this protein. A total of 769 IKBKB products are currently listed.
Synonyms:
AI132552, AIM-1, anon-89Bd, CG4201, DIK, dIKK, dIKK-beta, dIKKbeta, dLak, Dmel\\CG4201, DmIKK, Dmikkb, dmIKKbeta, Ik, IKBKB, ikk, IKK-2, IKK-beta, IKK2, Ikkb, Ikkbeta, IKK[b], ird, Ird-5, Ird5, ird5/DmIkk[beta], Lak, LRK, NFKBIKB
list all proteins Gene Name GeneID UniProt
IKBKB 3551 O14920
IKBKB 84351 Q9QY78
IKBKB 16150 O88351

Show all synonyms

IKBKB Proteins (IKBKB) by Origin

Select your origin of interest

Top referenced IKBKB Proteins

  1. Human IKBKB Protein expressed in Wheat germ - ABIN1307638 : Tai, Su, Ma, Lee: SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. in The Journal of biological chemistry 2009 (PubMed)

More Proteins for IKBKB Interaction Partners

Xenopus laevis Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) interaction partners

  1. crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) interaction partners

  1. N-acetyl-seryl-aspartyl-lysyl-proline inhibition of TNF-alpha (show TNF Proteins) activation of canonical, i.e., IKK-beta-dependent, NF-kappaB (show NFKB1 Proteins) pathway and subsequent decrease in ICAM-1 (show ICAM1 Proteins) expression is achieved via inhibition of IKK-beta.

  2. our results demonstrate that miR (show MLXIP Proteins)-200b, a transcriptional target of NF-kappaB (show NFKB1 Proteins), suppresses breast cancer cell growth and migration, and NF-kappaB (show NFKB1 Proteins) activation, through downregulation of IKBKB, indicating that miR (show MLXIP Proteins)-200b has potential as a therapeutic target in breast cancer patients.

  3. The present research concluded that aspirin suppressed prostate cancer cell invasion by reducing MMP-9 (show MMP9 Proteins) activity and uPA (show PRAP1 Proteins) expression through decreasing of IKK-beta-mediated NF-kappaB (show NFKB1 Proteins) activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.

  4. miR (show MLXIP Proteins)-429 is involved in regulation of the NF-kappaB (show NFKB1 Proteins) pathway by targeting IKKbeta and functions as a tumor suppressor in cervical carcinogenesis.

  5. TLR signaling led to lower expression of LRRC14 (show LRRC14 Proteins).

  6. results uncover a previously unidentified role of IKKbeta in regulating glycolysis, sensing low-glutamine-induced metabolic stress, and promoting cellular adaptation to nutrient availability.

  7. data clearly demonstrate that KLHL21 (show KLHL21 Proteins) negatively regulates TNFalpha (show TNF Proteins)-activated NF-kappaB (show NFKB1 Proteins) signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB (show NFKB1 Proteins) regulation in cells.

  8. Cis (show CISH Proteins)- and trans-gnetin H suppress cytokine response in LPS (show IRF6 Proteins)-stimulated THP-1 cells by preventing activation of key signaling molecules, IKK-beta, IkappaB alpha (show NFKBIA Proteins), and p65 (show GORASP1 Proteins), involved in the NF-kappaB (show NFKB1 Proteins) pathway.

  9. The neuroprotective effects of celastrol and its analogues may be related to IKKbeta inhibition.

  10. Survivin (show BIRC5 Proteins) overexpression activates NFkappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins), which is important in the acquisition and maintenance of the oncogenic characteristics of esophageal squamous cell carcinoma.

Cow (Bovine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) interaction partners

  1. Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin (show PRL Proteins) in bovine mammary epithelial cells.

  2. Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.

  3. High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin (show INS Proteins)-mediated NO production.

  4. High glucose-induced IKK (show CHUK Proteins)-Hsp-90 (show HSP90 Proteins) interaction contributes to endothelial dysfunction.

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) interaction partners

  1. data clearly demonstrate that KLHL21 (show KLHL21 Proteins) negatively regulates TNFalpha (show TNF Proteins)-activated NF-kappaB (show NFKB1 Proteins) signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB (show NFKB1 Proteins) regulation in cells.

  2. Study used three experimental approaches to enhance the IKKbeta activity in the liver of obese mice and observed increased XBP1s activity, reduced endoplasmic reticulum stress, and a significant improvement in insulin (show INS Proteins) sensitivity and consequently in glucose homeostasis.

  3. Mutation of cysteine 46 in IKK-beta increases inflammatory responses.

  4. TAK1 and IKK2 are novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

  5. MyD88s is positively regulated by IKKbeta and CREB and negatively regulated by ERK1/2 signaling pathways.

  6. these results highlight an unexpected tumor suppressive function of IKKbeta/NF-kappaB (show NFKB1 Proteins) in cancer-associated fibroblasts.

  7. These results reveal a hitherto unknown role of mesenchymal IKKbeta in driving inflammation and enabling carcinogenesis in the intestine.

  8. results provide evidence for a previously unrecognized role of IKKbeta in the regulation of the growth plate that is mediated through stimulation-independent downregulation of MCP-5 (show CMA1 Proteins) in the perichondrium.

  9. IKKbeta was required in both for modification of their hippocampus-dependent appetitive, not consummatory behavior.

  10. The role of IKK2 in heart injury induced by ambient fine particulate matter is reported.

IKBKB Protein Profile

Protein Summary

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.

Alternative names and synonyms associated with IKBKB

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (ikbkb)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB)
  • immune response deficient 5 (ird5)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (Ikbkb)
  • inhibitor of kappaB kinase beta (Ikbkb)
  • AI132552 protein
  • AIM-1 protein
  • anon-89Bd protein
  • CG4201 protein
  • DIK protein
  • dIKK protein
  • dIKK-beta protein
  • dIKKbeta protein
  • dLak protein
  • Dmel\\CG4201 protein
  • DmIKK protein
  • Dmikkb protein
  • dmIKKbeta protein
  • Ik protein
  • IKBKB protein
  • ikk protein
  • IKK-2 protein
  • IKK-beta protein
  • IKK2 protein
  • Ikkb protein
  • Ikkbeta protein
  • IKK[b] protein
  • ird protein
  • Ird-5 protein
  • Ird5 protein
  • ird5/DmIkk[beta] protein
  • Lak protein
  • LRK protein
  • NFKBIKB protein

Protein level used designations for IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta , inhibitor of nuclear factor kappa-B kinase subunit beta , inhibitor of nuclear factor kappa-B kinase subunit beta-like , CG4201-PB , IKK-like protein , LPS-responsive kinase , LPS-responsive-kinase , cactus kinase , deficient 5 , immune response , ird5-PB , lipopolysaccharide activated kinase , mmune response deficient 5 , I-kappa-B kinase 2 , I-kappa-B-kinase beta , IKK-B , nuclear factor NF-kappa-B inhibitor kinase beta , IKK-beta , NFKBIKB , inhibitor of kappaB kinase beta , inhibitor of nuclear factor kappa B kinase beta subunit , inhibitor of kappa light chain gene enhancer in B cells, kinase beta , IKK2

GENE ID SPECIES
432200 Xenopus laevis
472749 Pan troglodytes
704683 Macaca mulatta
100142682 Felis catus
100393096 Callithrix jacchus
100440586 Pongo abelii
100471679 Ailuropoda melanoleuca
100551699 Anolis carolinensis
100588081 Nomascus leucogenys
44432 Drosophila melanogaster
3551 Homo sapiens
84351 Rattus norvegicus
482839 Canis lupus familiaris
100101471 Sus scrofa
281854 Bos taurus
426792 Gallus gallus
16150 Mus musculus
Selected quality suppliers for IKBKB Proteins (IKBKB)
Did you look for something else?