anti-Rat (Rattus) Insulin Receptor antibody for Immunocytochemistry

Recommended Insulin Receptor Antibody (supplied by: Log in to see )

Antigen
Insulin Receptor (INSR) Antibodies
  • CD220
  • HHF5
  • 4932439J01Rik
  • D630014A15Rik
  • IR
  • IR-A
  • IR-B
  • 18402
  • CG18402
  • DIHR
  • DILR
  • DIR
  • DIRH
  • DIRbeta
  • DInR
  • DInr
  • Dir-a
  • Dir-b
  • Dmel\\CG18402
  • INR
  • INS
  • Inr
  • Inr-alpha
  • Inr-beta
  • InsR
  • dINR
  • dIR
  • dIRH
  • dInR
  • dInr
  • dInsR
  • dinr
  • dir
  • er10
  • inr
  • insulin/insulin-like growth factor receptor
  • l(3)05545
  • l(3)93Dj
  • l(3)er10
  • lnR
  • ir-A
  • CTK-1
  • ir
  • INSR
  • NV14476
  • cd220
  • hhf5
  • insulin receptor
  • Insulin-like receptor
  • insulin receptor L homeolog
  • INSR
  • Insr
  • InR
  • LOC100122567
  • LOC100451802
  • insr.L
Epitope
N-Term
38
34
22
17
17
14
12
10
9
8
7
6
6
6
5
5
5
5
5
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus), Human
315
129
96
23
22
21
20
17
17
9
5
5
3
1
1
1
1
1
Host
Rabbit
252
88
8
1
1
Clonality
Polyclonal
Conjugate
This Insulin Receptor antibody is un-conjugated
26
18
12
11
10
9
4
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blotting (WB)
217
143
74
56
46
33
17
13
13
12
10
8
8
7
4
3
2
2
1
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Catalog No. ABIN5663544
$ 543.95
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1859481 ICC IHC IP WB Rabbit IgG AA 1114-1382 Log in to see Polyclonal

General

Antigen Insulin Receptor (INSR) Antibodies
Epitope N-Term
(38), (34), (22), (17), (17), (14), (12), (10), (9), (8), (7), (6), (6), (6), (5), (5), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Rat (Rattus), Human
(315), (129), (96), (23), (22), (21), (20), (17), (17), (9), (5), (5), (3), (1), (1), (1), (1), (1)
Host Rabbit
(252), (88), (8), (1), (1)
Clonality
Polyclonal
Conjugate This Insulin Receptor antibody is un-conjugated
(26), (18), (12), (11), (10), (9), (4), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blotting (WB)
(217), (143), (74), (56), (46), (33), (17), (13), (13), (12), (10), (8), (8), (7), (4), (3), (2), (2), (1)
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Product Details anti-Insulin Receptor Antibody

Target Details Insulin Receptor Application Details Handling Images
Purification Affinity purification
Immunogen N term -peptide of human INSR
Isotype IgG

Target Details Insulin Receptor

Product Details anti-Insulin Receptor Antibody Application Details Handling Images back to top
Antigen
Alternative Name INSR (INSR Antibody Abstract)
Background Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135, and Tyr1136) are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation. 1. Adams, T.E. et al. Cell. Mol. Life Sci. 57, 1050-1093. 2. Baserga, R. et al. Oncogene 19, 5574-5581. 3. Scheidegger, K.J. et al. J. Biol. Chem. 275, 38921-38928. 4. Hernandez-Sanchez, C. et al. J. Biol. Chem. 270, 29176-29181. 5. Lopaczynski, W. et al. Biochem. Biophys. Res. Commun. 279, 955-960. 6. Baserga, R. et al. Exp. Cell Res. 253, 1-6. 7. White, M.F. et al. J. Biol. Chem. 260, 9470-9478. 8. White, M.F. et al. J. Biol. Chem. 263, 2969-2980.  
Synonyms: INSR, CD220, HHF5 , Insulin Receptor beta
Gene ID 3643
UniProt P06213
Pathways NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity

Application Details

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Handling Images back to top
Application Notes Recommended dilutions: WB: 1:500-1:2000, ICC: 1:50-1:200, IP: 1:20-1:50
Restrictions For Research Use only

Handling

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Images back to top
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C

Images

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-Insulin Receptor (INSR) (N-Term) antibody (ABIN5663544) anti-Insulin Receptor (INSR) (N-Term) antibody