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anti-Human IRAK4 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended IRAK4 Antibody (supplied by: Log in to see )

Antigen
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Antibodies
  • zgc:55553
  • IRAK4
  • ipd1
  • irak-4
  • ny-ran-64
  • ny-ren-64
  • ren64
  • irak4
  • IPD1
  • IRAK-4
  • NY-REN-64
  • REN64
  • 8430405M07Rik
  • 9330209D03Rik
  • interleukin-1 receptor-associated kinase 4
  • Interleukin-1 receptor-associated kinase 4
  • IRAK4
  • irak4
  • LOC100227974
  • Irak4
Epitope
AA 330-360, pThr345
42
35
15
15
15
14
14
6
5
5
5
5
5
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
193
56
26
13
5
5
4
4
3
3
2
2
1
Host
Rabbit
143
32
26
Clonality
Polyclonal
Conjugate
This IRAK4 antibody is un-conjugated
9
8
7
6
5
5
4
3
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
154
89
26
26
25
12
11
8
7
6
3
2
2
2
1
1
1
Options
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Catalog No. ABIN2177052
$ 317.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN740310 IF (p) IHC (p) WB Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN2177053 IF (p) Alexa Fluor 350 Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN2177055 IF (p) Alexa Fluor 555 Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN2177054 IF (p) Alexa Fluor 488 Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN2177056 IF (p) Alexa Fluor 647 Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN2177058 IF (p) Cy3 Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN2177060 IF (p) Cy5.5 Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN2177061 IF (p) Cy7 Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN2177062 IF (p) FITC Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN2177059 IF (p) Cy5 Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN2814908 IF (p) Alexa Fluor 594 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740313 IF (p) Cy3 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740315 IF (p) Cy5.5 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740317 IF (p) FITC Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740314 IF (p) Cy5 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740316 IF (p) Cy7 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN903055 IF (p) Alexa Fluor 488 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN903057 IF (p) Alexa Fluor 647 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN903056 IF (p) Alexa Fluor 555 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN903054 IF (p) Alexa Fluor 350 Rabbit IgG AA 20-55 Log in to see Polyclonal

Similar anti-IRAK4 Antibodies

Application / Reactivity Human
Dot Blot (DB) 1 Antibodies
ELISA 83 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 6 Antibodies
Flow Cytometry (FACS) 8 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 12 Antibodies
Immunofluorescence (IF) 11 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 26 Antibodies
Immunohistochemistry (IHC) 25 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 2 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 26 Antibodies
Immunoprecipitation (IP) 7 Antibodies
Intracellular Staining (ICS) 2 Antibodies
Western Blotting (WB) 146 Antibodies

General

Antigen Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Antibodies
Epitope AA 330-360, pThr345
(42), (35), (15), (15), (15), (14), (14), (6), (5), (5), (5), (5), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(193), (56), (26), (13), (5), (5), (4), (4), (3), (3), (2), (2), (1)
Host Rabbit
(143), (32), (26)
Clonality
Polyclonal
Conjugate This IRAK4 antibody is un-conjugated
(9), (8), (7), (6), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(154), (89), (26), (26), (25), (12), (11), (8), (7), (6), (3), (2), (2), (2), (1), (1), (1)
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Product Details anti-IRAK4 Antibody

Target Details IRAK4 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated Synthesised phosphopeptide derived from human IRAK4 around the phosphorylation site of Thr345
Isotype IgG

Target Details IRAK4

Product Details anti-IRAK4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name IRAK4 (IRAK4 Antibody Abstract)
Background

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

Subcellular location: Cytoplasm


Synonyms: IPD1, REN64, IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64, IRAK4
Gene ID 51135
UniProt Q9NWZ3
Research Area Atherosclerosis, Immunology, Receptors, Cytokines, Innate Immunity, Inflammation
Pathways NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response

Application Details

Product Details anti-IRAK4 Antibody Target Details IRAK4 Handling Images back to top
Application Notes IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-IRAK4 Antibody Target Details IRAK4 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-IRAK4 Antibody Target Details IRAK4 Application Details Handling back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-IRAK4 antibody (Interleukin-1 Receptor-Associated Kinase 4) (AA 330-360) (ABIN2177052) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti-IR...