You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Human MAP3K7 antibody for Dot Blot

Recommended MAP3K7 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Antibodies
  • B430101B05
  • C87327
  • MEKK7
  • si:ch211-225h9.1
  • TAK1
  • Tak1
  • TGF1a
  • zgc:110612
Epitope
pSer192
30
20
19
18
15
13
11
10
8
6
6
5
5
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
178
52
45
2
2
2
2
2
2
2
1
1
1
1
1
Host
Rabbit
157
14
12
Clonality
Polyclonal
Conjugate
This MAP3K7 antibody is un-conjugated
9
9
9
9
9
9
Application
Dot Blot (DB)
146
111
53
36
13
6
5
4
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Catalog No. ABIN389742
$ 324.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.59150326 ABIN389721 DB Rabbit Ig pThr187 Log in to see Polyclonal
0.59150326 ABIN2445321 DB Rabbit Ig Fraction pThr187 Log in to see Polyclonal
0.59150326 ABIN2445322 DB Rabbit Ig Fraction pSer192 Log in to see Polyclonal
0.0008929232 ABIN358312 DB EIA Rabbit Ig pSer192 Log in to see Polyclonal 5
0.0008929232 ABIN1955209 DB ELISA Biotin Rabbit IgG Thr187, pThr187 Log in to see Polyclonal
0.0008929232 ABIN1954959 DB ELISA WB Biotin Rabbit IgG Ser192 Log in to see Polyclonal
0.0008929232 ABIN1956108 DB ELISA WB FITC Rabbit IgG Ser192 Log in to see Polyclonal
0.0008929232 ABIN1956385 DB ELISA FITC Rabbit IgG Thr187, pThr187 Log in to see Polyclonal
0.0008929232 ABIN1952790 DB ELISA WB Alkaline Phosphatase (AP) Rabbit IgG Ser192 Log in to see Polyclonal
0.0008929232 ABIN1953075 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG Thr187, pThr187 Log in to see Polyclonal
0.0008929232 ABIN1953947 DB ELISA APC Rabbit IgG Thr187, pThr187 Log in to see Polyclonal
0.0008929232 ABIN1958435 DB ELISA WB PE Rabbit IgG Ser192 Log in to see Polyclonal
0.0008929232 ABIN1953662 DB ELISA WB APC Rabbit IgG Ser192 Log in to see Polyclonal
0.0008929232 ABIN1957332 DB ELISA WB HRP Rabbit IgG Ser192 Log in to see Polyclonal
0.0008929232 ABIN1957588 DB ELISA HRP Rabbit IgG Thr187, pThr187 Log in to see Polyclonal
0.0008929232 ABIN2587046 DB Rabbit IgG pThr187 Log in to see Polyclonal
0.0008929232 ABIN2587047 DB Rabbit IgG pSer192 Log in to see Polyclonal
0.0008929232 ABIN2307056 DB ELISA FITC Rabbit IgG pThr187 Log in to see Polyclonal
0.0008929232 ABIN2307052 DB Rabbit IgG pThr187 Log in to see Polyclonal
0.0008929232 ABIN2307063 DB ELISA WB FITC Rabbit IgG pSer192 Log in to see Polyclonal

Top referenced anti-MAP3K7 antibody for Dot Blot

Similar anti-MAP3K7 Antibodies

Application / Reactivity Human
Dot Blot (DB) 37 Antibodies
ELISA 110 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 5 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (IF) 4 Antibodies
Immunohistochemistry (IHC) 52 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 10 Antibodies
Immunoprecipitation (IP) 6 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
RNA Interference (RNAi) 1 Antibodies
Western Blotting (WB) 142 Antibodies

General

Antigen Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Antibodies
Epitope pSer192
(30), (20), (19), (18), (15), (13), (11), (10), (8), (6), (6), (5), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(178), (52), (45), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(157), (14), (12)
Clonality (Clone)
Polyclonal   ( )
Conjugate This MAP3K7 antibody is un-conjugated
(9), (9), (9), (9), (9), (9)
Application Dot Blot (DB)
(146), (111), (53), (36), (13), (6), (5), (4), (1), (1), (1), (1)
Supplier Log in to see

Product Details anti-MAP3K7 Antibody

Target Details MAP3K7 Application Details Handling Images
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen This MAP3K7 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S192 of human MAP3K7.
Clone RB11313
Isotype Ig

Target Details MAP3K7

Product Details anti-MAP3K7 Antibody Application Details Handling Images back to top
Antigen
Alternative Name MAP3K7 (MAP3K7 Antibody Abstract)
Background Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2- induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

Cellular Location
Cytoplasm. Cell membrane, Peripheral membrane protein, Cytoplasmic side. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane

Tissue Location
Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form

Synonyms: Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1, MAP3K7, TAK1,
Molecular Weight 67196 Da
Gene ID 6885
UniProt O43318
Research Area Cell Signaling, Protein Modifications, Phospho-specific antibodies, Transcription Factors, Signaling, Cell Structure
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway

Application Details

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Handling Images back to top
Application Notes Suggested dilutions:
DB = 1:500
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Images back to top
Format Liquid
Concentration 0.491 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months

Images

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Handling back to top
Supplier Images
Dot Blot (DB) image for anti-MAP3K7 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 7) (pSer192) (ABIN389742) Dot blot analysis of Phospho-MAP3K7-S192 polyclonal antibody (ABIN389742) on nitrocel...