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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||142 Antibodies||49 Antibodies||42 Antibodies|
|RNA Interference (RNAi)||1 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Immunoprecipitation (IP)||6 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||11 Antibodies||10 Antibodies||6 Antibodies|
|Immunohistochemistry (IHC)||53 Antibodies||20 Antibodies||17 Antibodies|
|Immunofluorescence (IF)||4 Antibodies||1 Antibodies|
|Antigen||Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MAP3K7 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-MAP3K7 AntibodyTarget Details MAP3K7 Application Details Handling References for anti-MAP3K7 Antibody (ABIN500865) Images
|Specificity||This antibody detects TAK1 / MAP3K7 at N-term.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, mouse, rat|
|Purification||Peptide affinity chromatography|
|Immunogen||Human TAK1 / MAP3K7 (N-Terminus) Peptide|
Target Details MAP3K7Product Details anti-MAP3K7 Antibody Application Details Handling References for anti-MAP3K7 Antibody (ABIN500865) Images back to top
|Alternative Name||TAK1 / MAP3K7 (MAP3K7 Antibody Abstract)|
|Background||TAK1 (TGF-β activated protein kinase 1) is a widely expressed enzyme originally identified as a mitogen-activated protein kinase kinase kinase (MAP3K7) (1). It has since been shown to mediate various intracellular signaling pathways, such as those induced by TGF-Β and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). TAK1 is normally present in cells in a complex with TAK1-binding protein 1 (TAB1) and either TAB2 or TAB3 (4,5). Association with TAB1 triggers TAK1 kinase activity by inducing TAK1 autophosphorylation (6), while TAB2 and possibly TAB3 may contribute to SAPK2a/p38a-mediated feedback inhibition of TAK1 activity (5).Synonyms: Mitogen-activated protein kinase kinase kinase 7, TAK-1, TAK1, TGF-beta-activated kinase 1, Transforming growth factor-beta-activated kinase 1|
|Pathways||NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-MAP3K7 Antibody Target Details MAP3K7 Handling References for anti-MAP3K7 Antibody (ABIN500865) Images back to top
ELISA. Western blot: 0.5 to 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details References for anti-MAP3K7 Antibody (ABIN500865) Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|
References for anti-MAP3K7 Antibody (ABIN500865)Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Handling Images back to top
Yamaguchi, Shirakabe, Shibuya et al.: "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction." in: Science (New York, N.Y.), Vol. 270, Issue 5244, pp. 2008-11, 1996 (PubMed).
ImagesProduct Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Handling References for anti-MAP3K7 Antibody (ABIN500865) back to top