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|Antigen||Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This NFKBIZ antibody is conjugated to Cy7 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
|Supplier||Log in to see|
Product Details anti-NFKBIZ AntibodyTarget Details NFKBIZ Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human IKB zeta|
Target Details NFKBIZProduct Details anti-NFKBIZ Antibody Application Details Handling Images back to top
|Alternative Name||Ikb zeta (NFKBIZ Antibody Abstract)|
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.
Synonyms: I-kappa-B-zeta, Ikappa B zeta, IkappaBzeta, IkB-zeta, IKBZ, IKBZ_HUMAN, IKBzeta, IL-1 inducible nuclear ankyrin-repeat protein, INAP, MAIL, MAIL protein, Molecule possessing ankyrin repeats induced by lipopolysaccharide, NF-kappa-B inhibitor zeta, NFKBIZ, Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor zeta.
|Research Area||Immunology, Innate Immunity, Cell Cycle, Apoptosis/Necrosis|
Application DetailsProduct Details anti-NFKBIZ Antibody Target Details NFKBIZ Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-NFKBIZ Antibody Target Details NFKBIZ Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|