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|Application / Reactivity||Mouse (Murine)||Human||Cow (Bovine)||Hamster||Monkey||Rabbit||Rat (Rattus)|
|Cytometry by Time of Flight (CyTOF)||1 Antibodies||1 Antibodies|
|Western Blotting (WB)||207 Antibodies||31 Antibodies||10 Antibodies||31 Antibodies||104 Antibodies||32 Antibodies||61 Antibodies|
|Radioimmunoassay (RIA)||8 Antibodies||2 Antibodies|
|Neutralization (Neut)||11 Antibodies||3 Antibodies|
|Mass Cytometry (CyTOF)||2 Antibodies|
|Luminex Assay (LMNX)||2 Antibodies|
|Intracellular Flow Cytometry (ICFC)||1 Antibodies|
|Immunoprecipitation (IP)||61 Antibodies||23 Antibodies||2 Antibodies||23 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies|
|Reactivity||Cow (Bovine), Hamster, Human, Monkey, Mouse (Murine), Rabbit, Rat (Rattus) Alternatives|
|Conjugate||This TNFRSF1A antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), Western Blotting (WB)
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Product Details anti-TNFRSF1A AntibodyTarget Details TNFRSF1A Application Details Handling Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412950|
|Specificity||The antibody detects cdc42 of human, mouse, rat, and bovine origins.|
|Immunogen||Synthetic peptide surrounding amino acid 32 of human TNF-RI|
Target Details TNFRSF1AProduct Details anti-TNFRSF1A Antibody Application Details Handling Images back to top
|Alternative Name||TNF-RI (TNFRSF1A Antibody Abstract)|
Tumor necrosis factor receptor 1 and 2 (TNF-R1 and TNF-R2) are 55 and 75 kDa. While TNF-R1 and TNF-R2 share 28 % sequence homology in the extracellular domains, their intracellular domains lack sequence homology, sμggesting that they differ in their internal signal transduction pathways. TNF-R1 contains an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal throμgh its interaction with TRADD (TNF-R1 associated death domain protein), and subsequent interactions with FADD. TNF-R1 can also activate the transcription factor NFkB via TRAF2 (TNF receptor associated factor 2). The cytoplasmic domain of TNF-R1 can directly interact with Jak kinase, thereby activating the JAK/STAT signal transduction cascade.
Synonyms: TNF-R1, Tumor Necrosis Factor type I, TNFRSF1A, TNFAR, TNF-R55, TNFR60, p55, CD120a
|Pathways||NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Handling Images back to top
Western blotting (0.5-4 μg/mL) and in Immunohistochemistry (10-20 μg/mL).
However, the optimal conditions should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Images back to top
|Buffer||100 μg (0.2 mg/mL) affinity purified rabbit anti-TNF-R1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
ImagesProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling back to top