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Human Monoclonal MIB2 Primary Antibody for ELISA, WB - ABIN530831
Jurd, Thornton, Wang, Luong, Phamluong, Kharazia, Gibb, Ron: Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. in The Journal of biological chemistry 2007
Mib and Mib2 interact with Fih-1 (show HIF1AN Antibodies) that is involved in the hypoxia signaling pathway.
Zebrafish Mib and Mib2 are colocalized in transfected cells and function redundantly in regulating Notch (show NOTCH1 Antibodies) signaling in embryos.
Missense p.V742G variant in MIB2 is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.
Here, we report a novel interaction between CYLD (show CYLD Antibodies) and MIB2 that supports the hypothesis that the CYLD (show CYLD Antibodies)/MIB2 interaction might play a pathogenic role in human cancer.
The DLAIS motif in MAVS (show MAVS Antibodies) was found to be critical for MIB2 binding, the ligation of K63-linked ubiquitin to TANK-binding kinase 1 (show TBK1 Antibodies), and phosphorylation-mediated IRF3 (show IRF3 Antibodies)/7 activation.
identify MIB2 as a novel component of the activated BCL10 (show BCL10 Antibodies) signaling complex and a missing link in the BCL10 (show BCL10 Antibodies)-dependent NF-kappaB (show NFKB1 Antibodies) signaling pathway.
Mib2 has functional similarities to Mib1, but might have distinct roles in Notch (show NOTCH1 Antibodies) signaling as an E3 ubiquitin ligase (show MUL1 Antibodies)
Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is down-regulated in melanoma.
skeletrophin is a novel ubiquitin ligase that targets the intracellular region of Jagged-2 (show JAG2 Antibodies) and is aberrantly overexpressed in multiple myeloma cells.
skeletrophin might be a novel suppressor factor for melanoma invasion
Data identify Mind bomb-2 as an E3 ubiquitin ligase (show MUL1 Antibodies) that interacts with and ubiquitinates the NR2B (show GRIN2B Antibodies) subunit of the NMDAR (show GRIN1 Antibodies) in mammalian cells.
created a targeted mutation of Mib2 and show that its phenotype is a variable penetrance, failure to close the cranial neural tube
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
E3 ubiquitin-protein ligase MIB2
, mind bomb homolog 2
, mindbomb homolog 2
, novel zinc finger protein
, putative NF-kappa-B-activating protein 002N
, zinc finger ZZ type with ankyrin repeat domain protein 1
, zinc finger, ZZ type with ankyrin repeat domain 1
, RBSC-skeletrophin/dystrophin-like polypeptide
, dystrophin-like protein
, mind bomb-2