MIB2 antibody (AA 925-975)

Catalog No. ABIN7452954

Product Details anti-MIB2 Antibody

Target: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Binding Specificity: AA 925-975

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIB2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit anti-MIB2/Skeletrophin Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 925 and 975

Isotype: IgG

Application Details

Application Notes:

IP: Not recommended

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MIB2

Target: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Alternative Name: MIB2/Skeletrophin (MIB2 Products)

Synonyms: ZZANK1 antibody, ZZZ5 antibody, 2210008I11Rik antibody, Zzank1 antibody, skd antibody, mib2 antibody, mindbomb E3 ubiquitin protein ligase 2 antibody, mindbomb E3 ubiquitin protein ligase 2 S homeolog antibody, MIB2 antibody, Mib2 antibody, mib2 antibody, mib2.S antibody

Background: Background: MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.

Gene ID: 142678

NCBI Accession: NP_543151

UniProt: Q96AX9

Pathways: Notch Signaling