MIB2 antibody

Catalog No. ABIN7113693

The Rabbit Polyclonal anti-MIB2 antibody (ABIN7113693) specifically detects MIB2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MIB2 antibody (ABIN7113693)

Target: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MIB2 Antibody

Purpose: MIB2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: mindbomb homolog 2(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MIB2

Target: MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))

Alternative Name: MIB2

Background:

Synonyms: E3 ubiquitin-protein ligase MIB2|Mind bomb homolog 2|Novel zinc finger protein (Novelzin)|Putative NF-kappa-B-activating protein 002N|RING-type E3 ubiquitin transferase MIB2|Skeletrophin|Zinc finger ZZ type with ankyrin repeat domain protein 1|MIB2|SKD|ZZANK1

Background: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors(By similarity).

Molecular Weight: 74 kDa, 82 kDa, 110 kDa

Gene ID: 142678

UniProt: Q96AX9

Pathways: Notch Signaling