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Browse our Nicastrin Proteins (NCSTN)

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Nicastrin Proteins (NCSTN)
On are 14 Nicastrin (NCSTN) Proteins from 7 different suppliers available. Additionally we are shipping Nicastrin Antibodies (124) and Nicastrin Kits (4) and many more products for this protein. A total of 152 Nicastrin products are currently listed.
9430068N19Rik, AA727311, agro, Aph2, CG7012, D1Dau13e, DKFZp469O2418, Dmel\\CG7012, dNct, Kiaa0253, mKIAA0253, NCSTN, Nct, nic, S5A, ST96B
list all proteins Gene Name GeneID UniProt
NCSTN 23385 Q92542
NCSTN 59287 P57716
NCSTN 289231 Q8CGU6

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Nicastrin Proteins (NCSTN) by Origin

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Top referenced Nicastrin Proteins

  1. Human Nicastrin Protein expressed in Human Cells - ABIN2004046 : FELDMAN, CHANDLER, LEVY, GLASER: FAMILIAL ALZHEIMER'S DISEASE. in Neurology 1970 (PubMed)
    Show all 3 references for ABIN2004046

  2. Mouse (Murine) Nicastrin Protein expressed in Human Cells - ABIN2008422 : Satoh, Kuroda: Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines. in Neuropathology : official journal of the Japanese Society of Neuropathology 2001 (PubMed)
    Show all 3 references for ABIN2008422

More Proteins for Nicastrin Interaction Partners

Fruit Fly (Drosophila melanogaster) Nicastrin (NCSTN) interaction partners

  1. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.

  2. Co-expression of Drosophila Pen-2 (show PSENEN Proteins) with Aph-1 and nicastrin increases the formation of Psn fragments as well as gamma-secretase activity

  3. Aph-1 and Nct may form a subcomplex that stabilizes the Psn holoprotein at an early step in gamma-secretase assembly.

  4. the proper assembly of the Aph-1.nicastrin subcomplex with presenilin is the prerequisite for the trafficking as well as the enzymatic activity of the gamma-secretase complex and Aph-1 functions as a stabilizing scaffold in the assembly of this complex

  5. presenilin, nicastrin, APH-1, and PEN-2 (show PSENEN Proteins), are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes

  6. Nicastrin is essential to early photoreceptor neuron development

Zebrafish Nicastrin (NCSTN) interaction partners

  1. Zebrafish have an orthologue of human NCSTN, transcripts of the zebrafish ncstn gene are provided maternally, and the gene is then transcribed throughout embryogenesis and in adult zebrafish. Zebrafish ncstn transcripts are present in ventricular cells of the developing brain, Ncstn protein likely plays a role in Notch (show NOTCH1 Proteins) signaling within the proliferative ventricular zone.

Human Nicastrin (NCSTN) interaction partners

  1. The results lead the investigators to speculate that NCSTN may be one of the genes determining the clinical phenotype of follicular HS .

  2. Loss of function of nicastrin impacts on cell proliferation and differentiation-associated signalling pathways in a keratinocyte cell line.

  3. analysis of two novel mutations segregating with familial hidradenitis suppurativa (acne inversa) and acne conglobate in NCSTN

  4. Case Report: large Chinese family harboring novel NCSTN mutation associated with acne inversa.

  5. Nicastrin mutation is associated with schizophrenia.

  6. haploinsufficiency of the NCSTN gene caused by the nonsense mutation c.1258C>T (p.Q420X) contributes to the occurrence of hidradenitis suppurativa in this family.

  7. The "Lid" domain of nicastrin is not essential for regulating gamma-secretase activity.

  8. SNPs in Notch (show NOTCH1 Proteins) pathway genes may be predictors of cutaneous melanoma disease-specific survival.

  9. Tumor necrosis factor-alpha (show TNF Proteins) and interleukin-10 (show IL10 Proteins) levels were elevated in acne inversa patients with nicastrin or presenilin enhancer (show PSENEN Proteins) mutation.

  10. A strategy focused on MAPT (show MAPT Proteins), APP (show APP Proteins), NCSTN and BACE1 (show BACE Proteins) to build blood classifiers for Alzheimer's disease.

Mouse (Murine) Nicastrin (NCSTN) interaction partners

  1. mice defective of the nicastrin subunit of gamma-secretase in oligodendrocytes have hypomyelination in the central nervous system.

  2. The results of this study showed that elevated p-tau levels in NCT cKO mice and have demonstrated that changes on p-tau were likely caused by enhanced activity of CDK5 but not GSK3beta.

  3. PS1 (show PSEN1 Proteins)(exon8) interacts with nicastrin, participating in the gamma-secretase complex formation.

  4. nicastrin plays essential roles in the regulation of short- and long-term synaptic plasticity, highlighting the importance of gamma-secretase in the function of mature synapses

  5. These results reveal a key role for ncstn in modulating amyloid beta production and amyloid plaque formation.

  6. Upregulation of PS1 (show PSEN1 Proteins)/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.

  7. Pen-2, as well as nicastrin and Aph-1alpha, is dispensable for presenilin endoproteolysis

  8. SGK1 (show SGK1 Proteins) is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.

  9. We propose a model that identifies critical TMDs of Aph-1 for associations with Nct and PS for the stepwise assembly of gamma-secretase components.

  10. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.

Nicastrin (NCSTN) Protein Profile

Protein Summary

This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.

Alternative names and synonyms associated with Nicastrin (NCSTN)

  • nicastrin (NCSTN)
  • nicastrin (nct)
  • nicastrin (ncstn)
  • nicastrin (CpipJ_CPIJ001617)
  • nicastrin (Ncstn)
  • Protein APH-2 (aph-2)
  • 9430068N19Rik protein
  • AA727311 protein
  • agro protein
  • Aph2 protein
  • CG7012 protein
  • D1Dau13e protein
  • DKFZp469O2418 protein
  • Dmel\\CG7012 protein
  • dNct protein
  • Kiaa0253 protein
  • mKIAA0253 protein
  • NCSTN protein
  • Nct protein
  • nic protein
  • S5A protein
  • ST96B protein

Protein level used designations for Nicastrin Proteins (NCSTN)

CG7012-PA , CG7012-PC , CG7012-PD , CG7012-PE , agoraphobic , dNicastrin , nct-PA , nct-PC , nct-PD , nct-PE , nicastrin , ATAG1874 , anterior pharynx-defective 2 , membrane protein

100058515 Equus caballus
42964 Drosophila melanogaster
457435 Pan troglodytes
488638 Canis lupus familiaris
494449 Danio rerio
719696 Macaca mulatta
6032584 Culex quinquefasciatus
100170459 Xenopus (Silurana) tropicalis
100172503 Pongo abelii
100549548 Meleagris gallopavo
100596812 Nomascus leucogenys
23385 Homo sapiens
59287 Mus musculus
289231 Rattus norvegicus
426905 Gallus gallus
100156098 Sus scrofa
514929 Bos taurus
172905 Caenorhabditis elegans
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