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Human Nicastrin Protein expressed in Human Cells - ABIN2004046
FELDMAN, CHANDLER, LEVY, GLASER: FAMILIAL ALZHEIMER'S DISEASE. in Neurology 1970
Show all 3 references for ABIN2004046
Mouse (Murine) Nicastrin Protein expressed in Human Cells - ABIN2008422
Satoh, Kuroda: Nicastrin, a key regulator of presenilin function, is expressed constitutively in human neural cell lines. in Neuropathology : official journal of the Japanese Society of Neuropathology 2001
Show all 3 references for ABIN2008422
Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.
Co-expression of Drosophila Pen-2 (show PSENEN Proteins) with Aph-1 and nicastrin increases the formation of Psn fragments as well as gamma-secretase activity
Aph-1 and Nct may form a subcomplex that stabilizes the Psn holoprotein at an early step in gamma-secretase assembly.
the proper assembly of the Aph-1.nicastrin subcomplex with presenilin is the prerequisite for the trafficking as well as the enzymatic activity of the gamma-secretase complex and Aph-1 functions as a stabilizing scaffold in the assembly of this complex
presenilin, nicastrin, APH-1, and PEN-2 (show PSENEN Proteins), are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes
Nicastrin is essential to early photoreceptor neuron development
Zebrafish have an orthologue of human NCSTN, transcripts of the zebrafish ncstn gene are provided maternally, and the gene is then transcribed throughout embryogenesis and in adult zebrafish. Zebrafish ncstn transcripts are present in ventricular cells of the developing brain, Ncstn protein likely plays a role in Notch (show NOTCH1 Proteins) signaling within the proliferative ventricular zone.
haploinsufficiency of the NCSTN gene caused by the nonsense mutation c.1258C>T (p.Q420X) contributes to the occurrence of hidradenitis suppurativa in this family.
The "Lid" domain of nicastrin is not essential for regulating gamma-secretase activity.
SNPs in Notch (show NOTCH1 Proteins) pathway genes may be predictors of cutaneous melanoma disease-specific survival.
Tumor necrosis factor-alpha (show TNF Proteins) and interleukin-10 (show IL10 Proteins) levels were elevated in acne inversa patients with nicastrin or presenilin enhancer (show PSENEN Proteins) mutation.
A strategy focused on MAPT (show MAPT Proteins), APP (show APP Proteins), NCSTN and BACE1 (show BACE Proteins) to build blood classifiers for Alzheimer's disease.
Akt1 (show AKT1 Proteins) phosphorylates NCT at Ser437, significantly reducing NCT stability. A phospho-deficient mutation in NCT at Ser437 stabilized its protein levels.
We suggest that this is the first description of an NCSTN nonsense mutation causing autosomal dominant hidradenitis suppurativa in an African American family.
analysis of how the conformation of presenilin, Pen-2 (show PSENEN Proteins), Aph-1, and nicastrin affect the function and mechanism of gamma-secretase
High nicastrin expression is associated with invasive breast cancer.
Analysis of nicastrin structure provides insights into the assembly and architecture of the gamma-secretase complex.
PS1 (show PSEN1 Proteins)(exon8) interacts with nicastrin, participating in the gamma-secretase complex formation.
nicastrin plays essential roles in the regulation of short- and long-term synaptic plasticity, highlighting the importance of gamma-secretase in the function of mature synapses
These results reveal a key role for ncstn in modulating amyloid beta production and amyloid plaque formation.
Upregulation of PS1 (show PSEN1 Proteins)/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.
Pen-2, as well as nicastrin and Aph-1alpha, is dispensable for presenilin endoproteolysis
SGK1 (show SGK1 Proteins) is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.
We propose a model that identifies critical TMDs of Aph-1 for associations with Nct and PS for the stepwise assembly of gamma-secretase components.
we found gamma-secretase components, including nicastrin, to cleave BCG (show SLC11A1 Proteins)-derived Ag85B to produce a peptide epitope
single residues in a gamma-secretase component besides presenilin are able to differentially affect amyloid precursor protein (show APP Proteins) and Notch (show NOTCH1 Proteins) processing.
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.
, anterior pharynx-defective 2
, membrane protein