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Nicastrin Protein (NCSTN) (Myc-DYKDDDDK Tag)

NCSTN Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2727295
  • Target See all Nicastrin (NCSTN) Proteins
    Nicastrin (NCSTN)
    Protein Type
    Recombinant
    Origin
    • 4
    • 2
    • 2
    Human
    Source
    • 3
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Nicastrin protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Nicastrin protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product NCSTN Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    Nicastrin (NCSTN)
    Alternative Name
    Nicastrin (NCSTN Products)
    Synonyms
    CG7012 Protein, Dmel\\CG7012 Protein, Nct Protein, Nic Protein, S5A Protein, ST96B Protein, agro Protein, dNct Protein, nic Protein, NCSTN Protein, DKFZp469O2418 Protein, APH2 Protein, 9430068N19Rik Protein, AA727311 Protein, Aph2 Protein, D1Dau13e Protein, Kiaa0253 Protein, mKIAA0253 Protein, nicastrin Protein, Nicastrin Protein, NCSTN Protein, nct Protein, ncstn Protein, CpipJ_CPIJ001617 Protein, Ncstn Protein, aph-2 Protein
    Background
    Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. [UniProtKB/Swiss-Prot Function]
    Molecular Weight
    75.2 kDa
    NCBI Accession
    NP_056146
    Pathways
    Notch Signaling, Neurotrophin Signaling Pathway
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