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Nicastrin Products

(Nicastrin (NCSTN))

Categories

This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].

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Featured Nicastrin Categories

Nicastrin Antibodies

High quality antibodies with extensive validation data.

Nicastrin ELISA Kits

Reliable ELISA kits for a wide range of species.

Nicastrin Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Nicastrin Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN565059
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN7268905
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
  • (1)
  • (1)
Cat. No. ABIN761801
Quantity 100 μL
Datasheet Datasheet

Recommended Nicastrin ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4883865
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730247
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1145111
Quantity 96 tests
Datasheet Datasheet

Recommended Nicastrin Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312150
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312152
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7320108
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Nicastrin products

Ku, Li, Gao, Zhang, Yan, Ji, Li, Sang: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).

Lombardo, Filipović, Molyneux, Periyasamy, Giamas, Hu, Trivedi, Wang, Yagüe, Michel, Coombes: "Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 41, pp. 16558-63, (2012) (PubMed).

Nguyen, Hawkins, Bergeron, Supala, Huang, Westaway, St George-Hyslop, Rozmahel: "Loss of nicastrin elicits an apoptotic phenotype in mouse embryos." in: Brain research, Vol. 1086, Issue 1, pp. 76-84, (2006) (PubMed).

Periz, Fortini: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).

Weihofen, Martoglio: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." in: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, (2003) (PubMed).

Marlow, Canet, Haugabook, Hardy, Lahiri, Sambamurti: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).

Li, Fici, Mao, Myers, Shuang, Donoho, Pauley, Himes, Qin, Kola, Merchant, Nye: "Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model." in: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 33445-9, (2003) (PubMed).

Synonyms and alternative names related to Nicastrin

nicastrin (NCSTN), nicastrin (nct), nicastrin (ncstn), nicastrin (CpipJ_CPIJ001617), nicastrin (Ncstn), Nicastrin (aph-2), 9430068N19Rik, AA727311, agro, APH2, Aph2, CG7012, D1Dau13e, DKFZp469O2418, Dmel\\CG7012, dNct, Kiaa0253, mKIAA0253, NCSTN, Nct, Nic, nic, S5A, ST96B

Protein level used designations for Nicastrin

  • CG7012-PA
  • CG7012-PC
  • CG7012-PD
  • CG7012-PE
  • agoraphobic
  • dNicastrin
  • nct-PA
  • nct-PC
  • nct-PD
  • nct-PE
  • nicastrin
  • ATAG1874
  • anterior pharynx-defective 2
  • membrane protein
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