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Human RBPJ Protein expressed in Wheat germ - ABIN2752917
Mangé, Lacombe, Bascoul-Mollevi, Jarlier, Lamy, Rouanet, Maudelonde, Solassol: Serum autoantibody signature of ductal carcinoma in situ progression to invasive breast cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
structural and biophysical studies demonstrate that RITA (show ZNF331 Proteins) binds RBP-J similarly to the RAM (show RAB27A Proteins) (RBP-J-associated molecule) domain of Notch (show NOTCH1 Proteins), our biochemical and cellular assays suggest that RITA (show ZNF331 Proteins) interacts with additional regions in RBP-J.
The present findings indicate that p53 (show TP53 Proteins), in turn, decreases CSL (show CSHL1 Proteins) expression, which can serve to enhance p53 (show TP53 Proteins) activity in acute DNA damage response of cells.
RBP-J mediated by miR (show MLXIP Proteins)-133a probably contributed to the regulation of DCs maturation and activation in osteosarcoma
These results suggest that PSK (show TAOK2 Proteins) suppresses Hedgehog (show SHH Proteins) signaling through down-regulation of MAML3 and RBPJ transcription under hypoxia, inhibiting the induction of a malignant phenotype in pancreatic cancer. Our results may lead to development of new treatments for refractory pancreatic cancer using PSK (show TAOK2 Proteins) as a Hedgehog (show SHH Proteins) inhibitor
our findings reconcile the 2 biological events and point to a multistep process of CAF (show KAT2B Proteins) activation under convergent CSL (show CSHL1 Proteins) and p53 (show TP53 Proteins) control. Activation of p53 (show TP53 Proteins) provides a failsafe mechanism against consequences of compromised CSL (show CSHL1 Proteins) activity in stromal cells.
RBPJ polymorphism [rs874040(CC) allele] skews memory T cells toward a pro-inflammatory phenotype involving Notch (show NOTCH1 Proteins) signaling, thus increasing the susceptibility to develop rheumatoid arthritis.
The role of CSL (show CSHL1 Proteins)-dependent and independent Notch (show NOTCH1 Proteins) signaling pathways in cell apoptosis is described in normal tissue homeostasis and in tumorigenesis. (Review)
These results support a model in which EBNA2 and EBNA3s compete for distinct subsets of RBPJ sites to regulate cell genes and where EBNA3 subset specificity is determined by interactions with other cell transcription factors.
Suggest that hypoxia promotes SMO transcription through upregulation of MAML3 and RBPJ to induce proliferation, invasiveness and tumorigenesis in pancreatic cancer.
data suggest that shRNA intervention of RBPJ expression could be a promising therapeutic approach for treating human prostate cancer
findings reveal that, in response to Wnt (show WNT2 Proteins) signalling, Dishevelled (show DVL2 Proteins) inhibits CSL (show SMPX Proteins) transcription factors to regulate Notch (show NOTCH1 Proteins) signalling and cell-fate decisions in vivo
The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52 (show C12orf52 Proteins)) as a novel rbpj/CBF-1-interacting protein.
The results suggest that a cell-to-cell interaction via the Notch (show NOTCH1 Proteins)/Su(H) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility.
This "target protector and rescue assay" demonstrates that the phenotypic defects associated with CUGBP1 inactivation in Xenopus are essentially due to the deregulation of Su(H) mRNA.
structural and biophysical studies demonstrate that RITA (show C12orf52 Proteins) binds RBP-J similarly to the RAM (show FAM103A1 Proteins) (RBP-J-associated molecule) domain of Notch (show NOTCH1 Proteins), our biochemical and cellular assays suggest that RITA (show C12orf52 Proteins) interacts with additional regions in RBP-J.
Intronic Flk1 (show KDR Proteins) genetic enhancer element directs arterial-specific expression via RBPJ-mediated venous repression.
Rbpj-kappa mediated Notch (show NOTCH1 Proteins) signaling plays a critical role in development of hypothalamic Kisspeptin neurons.
Results reveal an essential role for canonical Notch (show NOTCH1 Proteins)/RBP-J signaling in hippocampal synaptic plasticity and suggest that role, at least in part, is mediated by the regulation of GABAergic signaling
The bone marrow contains a progenitor that expresses renin (show REN Proteins) throughout development and possesses a B-lymphocyte (show AKAP17A Proteins) pedigree. This cell requires RBP-J to differentiate.
functions as a transcriptional repressor on the promoter of the microRNA miR (show MLXIP Proteins)-155
DNA methylation-dependent binding of RBPJ to a GC repressor element can negatively regulate smooth muscl myosin heavy chain promoter activity and can inhibit marker gene expression in phenotypically modulated cells
Rbpj directly regulates the expression of uterine matrix metalloproteinase (show MMP20 Proteins) in a Notch (show NOTCH1 Proteins) pathway-dependent manner, which is required for normal post-implantation decidual remodeling.
RBP-J maintains the identity of the renin cell by not only activating genes characteristic of the myo-endocrine phenotype but also, preventing ectopic gene expression and adoption of an aberrant phenotype
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.
recombining binding protein suppressor of hairless
, H-2K binding factor-2
, RBP-J kappa
, immunoglobulin kappa J region recombination signal binding protein 1
, renal carcinoma antigen NY-REN-30
, suppressor of hairless homolog
, suppressor of hairless protein 1
, suppressor of hairless protein homolog
, J kappa-recombination signal-binding protein