Browse our RBPJ Proteins (RBPJ)

Full name:
Recombination Signal Binding Protein For Immunoglobulin kappa J Region Proteins (RBPJ)
On www.antibodies-online.com are 8 Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) Proteins from 4 different suppliers available. Additionally we are shipping RBPJ Antibodies (86) and many more products for this protein. A total of 100 RBPJ products are currently listed.
Synonyms:
AI843960, AOS3, CBF1, csl, Igkjrb, IGKJRB1, Igkrsbp, KBF2, RBP-J, RBP-J kappa, RBPjk, Rbpsuh, Su(H), SUH, XSu(H), xsu(h)1
list all proteins Gene Name GeneID UniProt
Rat RBPJ RBPJ 679028  
RBPJ 3516 Q06330
RBPJ 19664 P31266

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RBPJ Proteins (RBPJ) by Origin

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Top referenced RBPJ Proteins

  1. Human RBPJ Protein expressed in Wheat germ - ABIN2752917 : Mangé, Lacombe, Bascoul-Mollevi, Jarlier, Lamy, Rouanet, Maudelonde, Solassol: Serum autoantibody signature of ductal carcinoma in situ progression to invasive breast cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012 (PubMed)

More Proteins for RBPJ Interaction Partners

Human Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) interaction partners

  1. RBPJ links MYC (show MYC Proteins) and transcriptional control through CDK9 (show CDK9 Proteins) in brain tumors, providing potential nodes of fragility for therapeutic intervention, potentially distinct from NOTCH (show NOTCH1 Proteins)

  2. Mean CBF1 expression is significantly increased in isocitrate dehydrogenase 1 (IDH1 (show IDH1 Proteins)) R132H mutant glioblastoma. Hypoxic regions of glioblastoma have higher CBF1 activation and exposure to low oxygen can induce its expression in glioma cells in vitro.

  3. structural and biophysical studies demonstrate that RITA (show ZNF331 Proteins) binds RBP-J similarly to the RAM (show RAB27A Proteins) (RBP-J-associated molecule) domain of Notch (show NOTCH1 Proteins), our biochemical and cellular assays suggest that RITA (show ZNF331 Proteins) interacts with additional regions in RBP-J.

  4. The present findings indicate that p53 (show TP53 Proteins), in turn, decreases CSL (show CSHL1 Proteins) expression, which can serve to enhance p53 (show TP53 Proteins) activity in acute DNA damage response of cells.

  5. RBP-J mediated by miR (show MLXIP Proteins)-133a probably contributed to the regulation of DCs maturation and activation in osteosarcoma

  6. These results suggest that PSK (show TAOK2 Proteins) suppresses Hedgehog (show SHH Proteins) signaling through down-regulation of MAML3 and RBPJ transcription under hypoxia, inhibiting the induction of a malignant phenotype in pancreatic cancer. Our results may lead to development of new treatments for refractory pancreatic cancer using PSK (show TAOK2 Proteins) as a Hedgehog (show SHH Proteins) inhibitor

  7. our findings reconcile the 2 biological events and point to a multistep process of CAF (show KAT2B Proteins) activation under convergent CSL (show CSHL1 Proteins) and p53 (show TP53 Proteins) control. Activation of p53 (show TP53 Proteins) provides a failsafe mechanism against consequences of compromised CSL (show CSHL1 Proteins) activity in stromal cells.

  8. RBPJ polymorphism [rs874040(CC) allele] skews memory T cells toward a pro-inflammatory phenotype involving Notch (show NOTCH1 Proteins) signaling, thus increasing the susceptibility to develop rheumatoid arthritis.

  9. The role of CSL (show CSHL1 Proteins)-dependent and independent Notch (show NOTCH1 Proteins) signaling pathways in cell apoptosis is described in normal tissue homeostasis and in tumorigenesis. (Review)

  10. These results support a model in which EBNA2 and EBNA3s compete for distinct subsets of RBPJ sites to regulate cell genes and where EBNA3 subset specificity is determined by interactions with other cell transcription factors.

Xenopus laevis Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) interaction partners

  1. findings reveal that, in response to Wnt (show WNT2 Proteins) signalling, Dishevelled (show DVL2 Proteins) inhibits CSL (show SMPX Proteins) transcription factors to regulate Notch (show NOTCH1 Proteins) signalling and cell-fate decisions in vivo

  2. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52 (show C12orf52 Proteins)) as a novel rbpj/CBF-1-interacting protein.

  3. The results suggest that a cell-to-cell interaction via the Notch (show NOTCH1 Proteins)/Su(H) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility.

  4. This "target protector and rescue assay" demonstrates that the phenotypic defects associated with CUGBP1 inactivation in Xenopus are essentially due to the deregulation of Su(H) mRNA.

Mouse (Murine) Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) interaction partners

  1. RBP-J-mediated Notch (show NOTCH1 Proteins) signalling is critical for basophil-dependent immunoregulation. Deficiency of RBP-J influences the immunoregulatory functions of BA, which include activation of T cells and their differentiation into T helper cell subtypes.

  2. Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (show MBD4 Proteins) plays role in enamel formation; Med1 (show MBD4 Proteins) induces Alpl (show ALPL Proteins) via stimulation of Notch1 (show NOTCH1 Proteins) signaling by forming Notch1 (show NOTCH1 Proteins)-RBP-Jk complex on Alpl (show ALPL Proteins) promoter. (Med1 (show MBD4 Proteins) = mediator complex subunit 1 (show MED1 Proteins); Alpl (show ALPL Proteins) = alkaline phosphatase, liver-bone-kidney; Notch1 (show NOTCH1 Proteins) = Notch gene homolog 1 (show NOTCH1 Proteins); RBP-Jk = kappa J region recombining binding protein suppressor of hairless)

  3. study uncovered a regulatory network, where miR (show MLXIP Proteins)-182 functions as an important new node that receives inputs from RBP-J and TNF-alpha (show TNF Proteins) signaling and positively regulates inflammatory osteoclastogenesis; suppression of miR (show MLXIP Proteins)-182 by RBP-J serves as an important mechanism that restrains TNF-alpha (show TNF Proteins) induced osteoclastogenesis

  4. structural and biophysical studies demonstrate that RITA (show C12orf52 Proteins) binds RBP-J similarly to the RAM (show FAM103A1 Proteins) (RBP-J-associated molecule) domain of Notch (show NOTCH1 Proteins), our biochemical and cellular assays suggest that RITA (show C12orf52 Proteins) interacts with additional regions in RBP-J.

  5. Intronic Flk1 (show KDR Proteins) genetic enhancer element directs arterial-specific expression via RBPJ-mediated venous repression.

  6. RBP-J mediated by miR (show MLXIP Proteins)-133a probably contributed to the regulation of DCs maturation and activation in osteosarcoma

  7. Rbpj-kappa mediated Notch (show NOTCH1 Proteins) signaling plays a critical role in development of hypothalamic Kisspeptin neurons.

  8. Results reveal an essential role for canonical Notch (show NOTCH1 Proteins)/RBP-J signaling in hippocampal synaptic plasticity and suggest that role, at least in part, is mediated by the regulation of GABAergic signaling

  9. The bone marrow contains a progenitor that expresses renin (show REN Proteins) throughout development and possesses a B-lymphocyte (show AKAP17A Proteins) pedigree. This cell requires RBP-J to differentiate.

  10. functions as a transcriptional repressor on the promoter of the microRNA miR (show MLXIP Proteins)-155

RBPJ Protein Profile

Protein Summary

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.

Alternative names and synonyms associated with RBPJ

  • recombination signal binding protein for immunoglobulin kappa J region (Rbpj)
  • recombination signal binding protein for immunoglobulin kappa J region (RBPJ)
  • recombination signal binding protein for immunoglobulin kappa J region (rbpj)
  • AI843960 protein
  • AOS3 protein
  • CBF1 protein
  • csl protein
  • Igkjrb protein
  • IGKJRB1 protein
  • Igkrsbp protein
  • KBF2 protein
  • RBP-J protein
  • RBP-J kappa protein
  • RBPjk protein
  • Rbpsuh protein
  • Su(H) protein
  • SUH protein
  • XSu(H) protein
  • xsu(h)1 protein

Protein level used designations for RBPJ

recombining binding protein suppressor of hairless , CBF-1 , H-2K binding factor-2 , RBP-J kappa , RBP-JK , immunoglobulin kappa J region recombination signal binding protein 1 , renal carcinoma antigen NY-REN-30 , suppressor of hairless homolog , X-Su(H) , suppressor of hairless protein 1 , suppressor of hairless protein homolog , J kappa-recombination signal-binding protein

GENE ID SPECIES
679028 Rattus norvegicus
3516 Homo sapiens
399453 Xenopus laevis
19664 Mus musculus
767928 Bos taurus
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