|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Functional Studies (Func)||1 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||2 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies|
|Western Blotting (WB)||8 Antibodies|
|Antigen||Ataxia Telangiectasia and Rad3 Related (ATR) Antibodies|
|Epitope||AA 710-1100 Alternatives|
Functional Studies (Func), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-ATR AntibodyTarget Details ATR Application Details Handling References for anti-ATR Antibody (ABIN151774) Images
|Purification||Protein G purified|
|Immunogen||Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.|
Target Details ATRProduct Details anti-ATR Antibody Application Details Handling References for anti-ATR Antibody (ABIN151774) Images back to top
|Alternative Name||ATR / FRP1 (ATR Antibody Abstract)|
Ataxia Telangiectasia Mutated (ATM) and Rad3- related (ATR) protein is a member ofthe phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has apredictedmolecular mass of approximately 301 kDa, and it has been shown to be involved incellular responses to DNA damage. Specifically, it plays a role in checkpoint activationin response to either the presence of stalled replication forks, or by the presence oflesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice. Alternate Names: anti-Ataxia Telangiecasia and Rad3 Related antibody, anti-FRAP Related Protein 1antibody, anti-FRP 1 antibody, anti-Human JTV 1 antibody, anti-protein kinase ATRantibody, anti-Rad3 related protein antibody, anti-SCKL antibody, anti-SCKL1 antibody,anti-Seckel syndrome antibody.
Gene Symbol: ATR
|Pathways||p53 Signaling, Apoptosis, DNA Damage Repair|
Application DetailsProduct Details anti-ATR Antibody Target Details ATR Handling References for anti-ATR Antibody (ABIN151774) Images back to top
Functional Assay and IP reported in literature (see Kulkarni, A. et al). Functional was reported in scientific literature.
Recommended dilutions: Functional, Immunocytochemistry/Immunofluorescence 1:10-1:2000, Immunoprecipitation 1:10-1:500, Western Blot 1:500-1:1000
|Restrictions||For Research Use only|
HandlingProduct Details anti-ATR Antibody Target Details ATR Application Details References for anti-ATR Antibody (ABIN151774) Images back to top
|Buffer||PBS, pH 7.2|
|Handling Advice||Avoid freeze-thaw cycles|
|Storage Comment||Aliquot and store at -20 °C or -80 °C.|
References for anti-ATR Antibody (ABIN151774)Product Details anti-ATR Antibody Target Details ATR Application Details Handling Images back to top
Post, Weng, Cimprich et al.: "Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 23, pp. 13102-7, 2001 (PubMed).
Abraham: "Cell cycle checkpoint signaling through the ATM and ATR kinases." in: Genes & development, Vol. 15, Issue 17, pp. 2177-96, 2001 (PubMed).
ImagesProduct Details anti-ATR Antibody Target Details ATR Application Details Handling References for anti-ATR Antibody (ABIN151774) back to top