anti-Dog (Canine) BAX antibody for Immunofluorescence

Recommended BAX Antibody (supplied by: Log in to see )

Antigen
BCL2-Associated X Protein (BAX) Antibodies
  • bax
  • fj16e01
  • wu:fc50b10
  • wu:fj16e01
  • bax-A
  • xBax
  • xlbax
  • BAX
  • BCL2L4
  • BAX-ALPHA
  • bcl2-associated X protein, a
  • BCL2-associated X protein
  • Bcl2-associated X protein
  • baxa
  • bax
  • BAX
  • Bax
  • LOC100355675
Epitope
AA 55-178
107
65
31
23
21
20
15
15
13
11
11
10
10
10
8
8
5
5
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human
497
221
202
89
47
35
29
28
22
9
8
8
5
3
3
2
1
1
1
1
Host
Mouse
323
203
4
Clonality
Monoclonal
Conjugate
This BAX antibody is un-conjugated
19
14
13
11
8
7
7
6
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
383
208
144
135
121
115
97
48
40
36
13
9
5
5
4
2
1
1
1
1
1
1
Options
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Catalog No. ABIN968295
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN386425 IF IHC (p) WB Mouse IgG1, kappa AA 3-16 Log in to see 2D2
1 ABIN386436 IF WB Biotin Mouse IgG1 AA 12-24 Log in to see 6A7
1 ABIN386438 IF WB Biotin Mouse IgG1 AA 12-24 Log in to see 6A7
1 ABIN386433 IF WB Mouse IgG1 AA 12-24 Log in to see 6A7
1 ABIN386434 IF WB Mouse IgG1 AA 12-24 Log in to see 6A7
1 ABIN386430 IF IHC (p) WB Biotin Mouse IgG1, kappa AA 3-16 Log in to see 2D2
1 ABIN386428 IF IHC (p) WB Biotin Mouse IgG1, kappa AA 3-16 Log in to see 2D2
1 ABIN386439 IF WB Mouse IgG1 AA 12-24 Log in to see 6A7
1 ABIN386426 IF IHC (p) WB Mouse IgG1, kappa AA 3-16 Log in to see 2D2
1 ABIN386431 IF IHC (p) WB Mouse IgG1, kappa AA 3-16 Log in to see 2D2
1 ABIN2738495 ELISA FACS IF IHC (p) IP WB Mouse IgG1 Log in to see 2D2

General

Antigen BCL2-Associated X Protein (BAX) Antibodies
Epitope AA 55-178
(107), (65), (31), (23), (21), (20), (15), (15), (13), (11), (11), (10), (10), (10), (8), (8), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Dog (Canine), Human
(497), (221), (202), (89), (47), (35), (29), (28), (22), (9), (8), (8), (5), (3), (3), (2), (1), (1), (1), (1)
Host Mouse
(323), (203), (4)
Clonality (Clone)
Monoclonal   ( )
Conjugate This BAX antibody is un-conjugated
(19), (14), (13), (11), (8), (7), (7), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(383), (208), (144), (135), (121), (115), (97), (48), (40), (36), (13), (9), (5), (5), (4), (2), (1), (1), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-BAX Antibody

Target Details BAX Application Details Handling ProductDetails: References for anti-BAX antibody (ABIN968295) Images
Cross-Reactivity Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human Bax-alpha aa. 55-178
Clone 3-Bax
Isotype IgG1

Target Details BAX

Product Details anti-BAX Antibody Application Details Handling ProductDetails: References for anti-BAX antibody (ABIN968295) Images back to top
Antigen
Alternative Name Bax (BAX Antibody Abstract)
Background Proper development and maintenance of homeostasis within tissues is achieved through cell proliferation, differentiation, and apoptosis. Members of the Bcl-2 protein family function to either inhibit (Bcl-2 and Bcl-XL) or promote (Bax and Bak) apoptosis. Similar to other family members, Bax contains the conserved Bcl-2 homology 1 (BH1) and 2 (BH2) domains which allow for its homodimerization or heterodimerization with Bcl-2. Although Bax alone does not induce cell death, elevated levels of Bax accelerate apoptosis following a death signal such as cytokine deprivation or Fas/Fas ligand interaction. The ratio of Bax homodimers to Bax/Bcl-2 heterodimers is an apoptotic checkpoint. When Bcl-2 is in excess, apoptosis is inhibited. However, if Bax levels increase in response to a death signal, the cell is pushed toward death. Bax function is also affected by Bax Inhibitor-1 (BI-1). Although it interacts directly with Bcl-2 and not Bax, BI-1 can suppress Bax-induced apoptosis. Alternative splicing of Bax mRNA produces Bax-alpha, the integral membrane form, and the two cytosolic forms beta and gamma. These isoforms are thought to allow for differential regulation of Bax activity and localization. This antibody is routinely tested by western blot analysis.
Molecular Weight 21 kDa
Research Area Cancer, Apoptosis/Necrosis
Pathways p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded protein response

Application Details

Product Details anti-BAX Antibody Target Details BAX Handling ProductDetails: References for anti-BAX antibody (ABIN968295) Images back to top
Comment

Related Products: ABIN968587, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-BAX Antibody Target Details BAX Application Details ProductDetails: References for anti-BAX antibody (ABIN968295) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

ProductDetails: References for anti-BAX antibody (ABIN968295)

Product Details anti-BAX Antibody Target Details BAX Application Details Handling Images back to top
Product cited in:

Kartasheva, Contente, Lenz-Stöppler, Roth, Dobbelstein: "p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop." in: Oncogene, Vol. 21, Issue 31, pp. 4715-27, 2002

Aoudjit, Vuori: "Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells." in: Oncogene, Vol. 20, Issue 36, pp. 4995-5004, 2001

Rytömaa, Lehmann, Downward: "Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling." in: Oncogene, Vol. 19, Issue 39, pp. 4461-8, 2000

Xu, Reed: "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast." in: Molecular cell, Vol. 1, Issue 3, pp. 337-46, 1998

Oltvai, Milliman, Korsmeyer: "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." in: Cell, Vol. 74, Issue 4, pp. 609-19, 1993

Images

Product Details anti-BAX Antibody Target Details BAX Application Details Handling ProductDetails: References for anti-BAX antibody (ABIN968295) back to top
Supplier Images
Western Blotting (WB) image for anti-BCL2-Associated X Protein (BAX) (AA 55-178) antibody (ABIN968295) Western blot analysis of Bax on a HepG2 cell lysate (Human hepatocellular carcinoma, ...
Immunofluorescence (IF) image for anti-BCL2-Associated X Protein (BAX) (AA 55-178) antibody (ABIN968295) Immunofluorescence staining of BC3H1 cells (Mouse brain smooth muscle-like cells, ATC...
 image for anti-BCL2-Associated X Protein (BAX) (AA 55-178) antibody (ABIN968295) anti-BCL2-Associated X Protein (BAX) (AA 55-178) antibody (Image 3)