anti-Human FAS antibody for Activation

Recommended FAS Antibody (supplied by: Log in to see )

Antigen
Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
  • AI196731
  • APO1
  • APT1
  • CD95
  • TNFR6
  • Tnfrsf6
  • lpr
  • TNFRSF6
  • ALPS1A
  • APO-1
  • FAS1
  • FASTM
  • A630082H08Rik
  • FAS
  • Fas (TNF receptor superfamily member 6)
  • Fas (TNF receptor superfamily, member 6)
  • Fas cell surface death receptor
  • fatty acid synthase
  • Fas
  • FAS
  • Fasn
Reactivity
Human
646
113
99
15
11
10
6
6
3
3
3
3
2
1
Host
Mouse
414
303
24
5
4
3
3
Clonality
Monoclonal
Conjugate
This FAS antibody is un-conjugated
73
63
51
29
15
8
7
7
5
5
5
4
4
4
4
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Activation (Act), ELISA
335
318
209
146
113
85
61
54
52
46
23
18
12
7
7
6
5
5
4
4
3
3
2
2
2
2
2
2
1
1
1
1
Supplier
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Catalog No. ABIN1002287
$ 385.77
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1060316 Act Inhibition Mouse Log in to see
1 ABIN1060315 Act Inhibition Mouse Log in to see

General

Antigen Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
Reactivity Human
(646), (113), (99), (15), (11), (10), (6), (6), (3), (3), (3), (3), (2), (1)
Host Mouse
(414), (303), (24), (5), (4), (3), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FAS antibody is un-conjugated
(73), (63), (51), (29), (15), (8), (7), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application Activation (Act), ELISA
(335), (318), (209), (146), (113), (85), (61), (54), (52), (46), (23), (18), (12), (7), (7), (6), (5), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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Product Details anti-FAS Antibody

Target Details FAS Application Details Handling Images
Predicted Reactivity Fas (CD95, activating)
Purification Ion exchange chromatography
Immunogen Purified recombint human Fas
Clone NYRhFAS
Isotype IgG1

Target Details FAS

Product Details anti-FAS Antibody Application Details Handling Images back to top
Antigen
Alternative Name Fas (CD95) (FAS Antibody Abstract)
Background The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligomerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated, to then cleave and activate downstream caspases, and a variety of cellular substrates that lead to cell death. Caspases cleave nuclear lamins, causing the nucleus to break down and lose its normal structure. Another caspase substrate is DFF, inducing cleavage and degradation of the genome. Other caspase substrates are involved in cytoskeletal structure, cell cycle regulation and signaling pathways. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of Fas-mediated apoptosis using similar mechanisms.
Pathways p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-FAS Antibody Target Details FAS Handling Images back to top
Application Notes In a direct ELISA, a 1:10,000 dilution will yield an O.D. of 0.5 using alkaline phosphatase-conjugated rabbit anti-mouse Ig. Optimal dilution has to be determined by user. Antibody might also be suited for other applications not tested so far. This is a BLOCKING antibody and will block FAS-mediated apoptosis.
Restrictions For Research Use only

Handling

Product Details anti-FAS Antibody Target Details FAS Application Details Images back to top
Format Lyophilized
Handling Advice Please Note: Always centrifuge product briefly before opening vial. Reconstitute with 0.5 ml sterile H20 or PBS to give a 1 mg/ml concentration. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Protein concentration: 1 mg/ml (after reconstitution).
Storage 4 °C/-20 °C