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anti-Human PAG1 Antibodies:
anti-Rat (Rattus) PAG1 Antibodies:
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Human Monoclonal PAG1 Primary Antibody for FACS, IHC (p) - ABIN94272
Yerly, Ding, Tauzin, van Echten-Deckert, Borisch, Hoessli: The sphingolipid-rich rafts of ALK+ lymphomas downregulate the Lyn-Cbp/PAG signalosome. in European journal of haematology 2010
Show all 6 Pubmed References
Human Monoclonal PAG1 Primary Antibody for IHC (p), IP - ABIN94270
Baumgartner, Angelisová, Setterblad, Mooney, Werling, Horejsí, Langsley: Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. in Blood 2003
Show all 5 Pubmed References
Cow (Bovine) Monoclonal PAG1 Primary Antibody for IHC (p), IP - ABIN269119
Yamashita, Chattopadhyay, Fensterl, Zhang, Sen: A TRIF-independent branch of TLR3 signaling. in Journal of immunology (Baltimore, Md. : 1950) 2012
Up-regulated expression of CBP (show CREBBP Antibodies) in Jurkat cells could reduce cell homogeneity and promote cell apoptosis
No association Pag1 mutation with patient with Schizophrenia.
The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation (show BLNK Antibodies) and have a pro-inflammatory effect.
CBP (show CREBBP Antibodies) may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src (show SRC Antibodies).
The inhibitory function of novobiocin in disrupting the HIF1alpha (show HIF1A Antibodies)/p300 (show EP300 Antibodies) complex might be important in tumor cell growth.
siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death.
expression of CBP (show CREBBP Antibodies) gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression.
An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK (show EPHB2 Antibodies), as well as the cyclin D1 (show CCND1 Antibodies) expression, leading to an inhibition of the proliferation ability of tumor cells.
Cbp (show CREBBP Antibodies) down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK (show MAPK1 Antibodies)/PI3K (show PIK3CA Antibodies) pathways in a subset of cancer cells.
Results indicate that Cbp is required for the Csk-mediated inactivation of c-Src and may control the promotion of malignancy in NSCLC tumors that are characterized by c-Src upregulation.
Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A (show PAPPA Antibodies) KO compared to WT mice. Moreover, 18-month-old PAPP-A (show PAPPA Antibodies) KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A (show PAPPA Antibodies) deficiency in mice is associated with indices of healthy skeletal muscle function with age.
our findings illustrate that Cbp (show CREBBP Antibodies) is an important regulator of Csk (show CSK Antibodies) recruitment to the SFK Lyn (show LYN Antibodies) in Eporesponsive erythroid cells.
Snell, GHKRO, and PAPPA (show PAPPA Antibodies)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (show MGMT Antibodies)) and N-myc downstream-regulated gene 1 (NDRG1 (show NDRG1 Antibodies)).
STC2 (show STC2 Antibodies) is involved in regulating PAPP-A (show PAPPA Antibodies) activity during the development of atherosclerosis
Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A (show PAPPA Antibodies).
stimulation of PAPP-A (show PAPPA Antibodies) expression by intermittent PTH (show PTH Antibodies) treatment contributes to PTH (show PTH Antibodies) bone anabolism in mice
PAPP-A (show PAPPA Antibodies) affects fascicle structure, thereby affecting tendon phenotype.
This study demonstrated that cbp (show CREBBP Antibodies) increase in skeletal muscle in muscle atrophy.
PAG is constitutively phosphorylated in resting T cells and rapidly dephosphorylated once the TCR is engaged.
If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
phosphoprotein associated with glycosphingolipid microdomains 1
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1-like
, Csk-binding protein
, phosphoprotein associated with glycosphingolipid-enriched microdomains 1
, transmembrane adapter protein PAG
, transmembrane adaptor protein PAG
, transmembrane phosphoprotein Cbp
, Csk binding protein
, csk-binding protein
, phosphoprotein transmembrane adaptor 1
, phosphoprotein-associated with GEMs
, IGF-dependent IGFBP-4 protease
, insulin-like growth factor-dependent IGF-binding protein 4 protease