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(GNAT3, 11 SNPs) gene, located within the 1-LOD support interval region for their association with MS and its related traits. Several SNPs were associated with MS and its related traits. Remarkably.
The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY.
the alpha-subunit (show POLG Proteins) of the taste-specific G protein gustducin is expressed prominently in cells of the human colon
Axonemal-associated localization within the midpiece and principal piece of human spermatozoa raises the possibility that this G protein alpha-subunit (show GNAO1 Proteins)may process intracellular signals controlling sperm motility.
T1R3 (show TAS1R3 Proteins) and alpha-gustducin exhibited a stage-dependent expression pattern during mouse development, and a cell-specific pattern during the spermatogenic cycle.
The role of alpha-gustducin in the development of obesity and adipocyte metabolism
speculate that TAS1R3 (show TAS1R3 Proteins) and GNAT3 activators may help infertile men, particularly those that are affected by some of the mentioned inhibitors and/or are diagnosed with idiopathic infertility involving signaling pathway of these receptors
Data suggest that alpha-gustducin in colonic mucosa is a key signaling molecule coupling free fatty acid receptors (Gpr43 (show FFAR2 Proteins), Gpr119 (show GPR119 Proteins), Gpr120) and possibly bile acid receptor (show NR1H4 Proteins) (TGR5 (show GPBAR1 Proteins)) to secretion of GLP-1 (glucagon-like peptide 1 (show GCG Proteins)).
This study provides the first evidence that alpha-gustducin is involved in the octanoylation of ghrelin (show GHRL Proteins).
Data suggest that proteins of the taste transduction cascade (alpha-gustducin, G-protein gamma13, and phospholipase Cbeta2) are expressed in testis and are in involved in spermatogenesis.
The evidence suggests that alpha-gustducin may selectively participate in signal transduction in the axon terminals of rod bipolar cells in the mammalian retina.
investigated whether T2R-agonists affect (i) ghrelin (show GHRL Proteins) release via alpha-gustducin and (ii) food intake and gastric emptying via the release of ghrelin (show GHRL Proteins)
(alpha)--gustducin may be involved in the gurmarin-sensitive sweet reception pathway and may be a key molecule for links between sweet taste receptors and cell type-specific-innervation by their matched fiber class.
alpha-transducin (show GNAT1 Proteins) has a role in taste receptor cells and taste cell responses that is different from alpha-gustducin
This study showed an upregulation of selected subpopulations of GNAT3 / alpha-transducin (show GNAT1 Proteins)-immunoreactive cells in distinct regions of the pig gastrointestinal tract by short- and long-term high protein diet.
The expression of alpha-transducin (show GNAT1 Proteins) in endocrine and non-endocrine cells located along the length of the porcine gastrointestinal tract is reported.[alpha-transducin (show GNAT1 Proteins)]
Axonemal-associated localization within the midpiece and principal piece of bovine spermatozoa raises the possibility that this G protein alpha-subunit (show GNAO1 Proteins) may process intracellular signals controlling sperm motility
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase\; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide- 1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
guanine nucleotide-binding protein G(t) subunit alpha-3
, guanine nucleotide binding protein, alpha transducing 3
, guanine nucleotide-binding protein G(t) subunit alpha-3-like
, gustducin alpha-3 chain