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anti-Human Cyclin D1 antibody for Immunohistochemistry (Frozen Sections)

Recommended Cyclin D1 Antibody (supplied by: Log in to see )

Antigen
Cyclin D1 (CCND1) Antibodies
  • AI327039
  • bcl-1
  • bcl1
  • BCL1
  • cb161
  • ccnd1
  • CCND1
  • ccnd1a
  • ccnd1b
  • ccndbp1
  • cD1
  • cycd1
  • CycD1
  • Cyl-1
  • d11s287e
  • D11S287E
  • etID37810.7
  • fb52e01
  • fc45c08
  • fc83a12
  • id:ibd1198
  • prad1
  • PRAD1
  • u21b31
  • U21B31
  • wu:fb52e01
  • wu:fc45c08
  • wu:fc83a12
  • ZHM
Reactivity
Human, Mouse (Murine), Rat (Rattus)
447
181
172
46
16
13
13
11
9
8
4
3
2
2
2
1
1
1
1
Host
Mouse
311
187
1
Clonality
Monoclonal
Conjugate
This Cyclin D1 antibody is un-conjugated
22
19
9
9
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
400
191
139
108
107
104
102
73
70
12
8
7
6
3
3
2
2
2
1
1
1
Supplier
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Catalog No. ABIN1106872
$ 313.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008842256 ABIN967539 IHC (f) IHC (fro) ICS IP WB Mouse IgG2a full length Log in to see DCS-6 4
0.0008842256 ABIN614708 EIA IHC (fro) IF IHC (p) IP WB Mouse IgG1 Log in to see CD1-1
0.0008842256 ABIN119000 EIA FACS IHC (fro) IHC (p) IP WB Mouse IgG1 Log in to see CD1-1
0.0008842256 ABIN302101 ICC FACS IHC (fro) IHC (p) IP ELISA WB Mouse IgG1 Log in to see CD1-1 2
0.0008842256 ABIN574432 ICC IHC (fro) FACS IHC (p) IP ELISA WB Mouse IgG1 Log in to see CD1-1
0.0008842256 ABIN3043639 ICC IHC (fro) IHC (p) WB Mouse IgG2a Log in to see DCS-6
0.0008842256 ABIN1501952 ICC IHC (fro) IHC (p) WB Mouse IgG2a Log in to see CYD1
0.0008842256 ABIN609471 ICC IHC (fro) IHC (p) WB Mouse IgG2a Log in to see
0.0008842256 ABIN1858284 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG AA 1-295 Log in to see Polyclonal
0.0008842256 ABIN1723570 ICC IHC (fro) FACS IHC (p) IP ELISA WB Mouse IgG1 Log in to see CD1-1
0.0008842256 ABIN255827 FACS IHC (fro) IHC (p) IP IHC ELISA WB Mouse IgG1 Log in to see CD1-1
0.0008842256 ABIN200701 FACS IHC (fro) IHC (p) IP ELISA WB Mouse IgG1 Log in to see
0.0008842256 ABIN870487 IHC (fro) IHC (p) Rabbit C-Term Log in to see E16-I
0.0008842256 ABIN1978979 IHC (fro) IHC (p) Rabbit C-Term Log in to see Polyclonal
0.0008842256 ABIN184391 IHC (fro) WB Rabbit Log in to see Polyclonal
0.0008842256 ABIN870490 IHC (fro) IHC (p) Rabbit C-Term Log in to see E16-I
0.0008842256 ABIN870492 IHC (fro) IHC (p) Rabbit C-Term Log in to see E16-I
0.0008842256 ABIN4301563 FACS ICC IF IHC (fro) IHC (p) IP WB Alexa Fluor 405 Mouse IgG2a kappa Log in to see SPM587
0.0008842256 ABIN4301564 FACS ICC IF IHC (fro) IHC (p) IP WB Alexa Fluor 488 Mouse IgG2a kappa Log in to see SPM587
0.0008842256 ABIN4301565 FACS ICC IF IHC (fro) IHC (p) IP WB Alexa Fluor 647 Mouse IgG2a kappa Log in to see SPM587

Top referenced anti-Cyclin D1 antibody for Immunohistochemistry (Frozen Sections)

Similar anti-Cyclin D1 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 64 Antibodies 64 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies 2 Antibodies
Flow Cytometry (FACS) 56 Antibodies 52 Antibodies
Immunochromatography (IC) 1 Antibodies 1 Antibodies
Immunocytochemistry (ICC) 62 Antibodies
Immunofluorescence (IF) 64 Antibodies
Immunofluorescence (Cultured Cells) (IF (cc)) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 47 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 50 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 64 Antibodies
Immunoprecipitation (IP) 66 Antibodies
Intracellular Staining (ICS) 1 Antibodies
Western Blotting (WB) 147 Antibodies

General

Antigen Cyclin D1 (CCND1) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(447), (181), (172), (46), (16), (13), (13), (11), (9), (8), (4), (3), (2), (2), (2), (1), (1), (1), (1)
Host Mouse
(311), (187), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Cyclin D1 antibody is un-conjugated
(22), (19), (9), (9), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(400), (191), (139), (108), (107), (104), (102), (73), (70), (12), (8), (7), (6), (3), (3), (2), (2), (2), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-Cyclin D1 Antibody

Target Details Cyclin D1 Application Details Handling References for anti-Cyclin D1 Antibody (ABIN1106872) Images
Specificity This antibody reacts to Cyclin D1.
Purification Affinity chromatography
Immunogen Recombinant human cyclin D1 protein
Clone CY-D1
Isotype IgG2a

Target Details Cyclin D1

Product Details anti-Cyclin D1 Antibody Application Details Handling References for anti-Cyclin D1 Antibody (ABIN1106872) Images back to top
Antigen
Alternative Name Cyclin D1 (CCND1 Antibody Abstract)
Background D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. CyclinD1(CCND1), also known as BCL1. Expression of cyclin D1, but not of cyclins A and E, was induced by transfection of the RB gene into RB-deficient tumor cells. cyclin D1 gene can function as an oncogene. Cyclin D1 expression is regulated by the retinoblastoma protein. The protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. Brisken et al. (2003) found that prolactin induced IGF2 mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland.Synonyms: BCL-1 oncogene, BCL1, CCND1, Cyclin-D1, G1/S-specific cyclin-D1, PRAD-1 oncogene, PRAD1
Gene ID 595
NCBI Accession NP_444284
UniProt P24385
Research Area Cancer, Cell Cycle
Pathways PI3K-Akt Signaling, Cell Division Cycle

Application Details

Product Details anti-Cyclin D1 Antibody Target Details Cyclin D1 Handling References for anti-Cyclin D1 Antibody (ABIN1106872) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Cyclin D1 Antibody Target Details Cyclin D1 Application Details References for anti-Cyclin D1 Antibody (ABIN1106872) Images back to top
Reconstitution Restore with 1.2 % sodium acetate or neutral PBS
Concentration 0,1 mg/mL
Buffer 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-Cyclin D1 Antibody (ABIN1106872)

Product Details anti-Cyclin D1 Antibody Target Details Cyclin D1 Application Details Handling Images back to top
Background publications

Müller, Lukas, Schneider, Warthoe, Bartek, Eilers, Strauss: "Cyclin D1 expression is regulated by the retinoblastoma protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 8, pp. 2945-9, 1994

Hinds, Dowdy, Eaton, Arnold, Weinberg: "Function of a human cyclin gene as an oncogene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 2, pp. 709-13, 1994

Rosenberg, Kim, Shows, Kronenberg, Arnold: "Rearrangement and overexpression of D11S287E, a candidate oncogene on chromosome 11q13 in benign parathyroid tumors." in: Oncogene, Vol. 6, Issue 3, pp. 449-53, 1991

Images

Product Details anti-Cyclin D1 Antibody Target Details Cyclin D1 Application Details Handling References for anti-Cyclin D1 Antibody (ABIN1106872) back to top
Supplier Images
Western Blotting (WB) image for anti-Cyclin D1 antibody (CCND1) (ABIN1106872) anti-Cyclin D1 (CCND1) antibody