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anti-Human MAP3K8 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended MAP3K8 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Antibodies
  • c-COT
  • Cot
  • COT
  • Cot/Tpl2
  • D17TPL2
  • Est
  • EST
  • ESTF
  • Estf
  • MAP3K8
  • MEKK8
  • Tpl-2
  • TPL2
  • Tpl2
Epitope
AA 370-420, pSer400
29
16
13
8
7
6
4
4
3
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
93
37
34
5
4
2
1
1
Host
Rabbit
89
4
Clonality
Polyclonal
Conjugate
This MAP3K8 antibody is un-conjugated
5
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
49
41
32
22
12
11
8
5
3
2
Supplier
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Catalog No. ABIN746573
$ 291.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008837127 ABIN746588 IF (p) IHC (p) Rabbit IgG AA 270-320, pThr290 Log in to see Polyclonal
0.0008837127 ABIN701275 IF (p) IHC (p) WB Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN905625 IF (p) Alexa Fluor 488 Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN905624 IF (p) Alexa Fluor 555 Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN905623 IF (p) Alexa Fluor 350 Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN905626 IF (p) Alexa Fluor 647 Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN701278 IF (p) Cy3 Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN701279 IF (p) Cy5 Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN701281 IF (p) Cy7 Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN701280 IF (p) Cy5.5 Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN701282 IF (p) FITC Rabbit IgG AA 140-190 Log in to see Polyclonal
0.0008837127 ABIN2803976 IF (p) Alexa Fluor 594 Rabbit IgG AA 140-190 Log in to see Polyclonal

Similar anti-MAP3K8 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine) Human
ELISA 14 Antibodies 13 Antibodies 41 Antibodies
Immunochromatography (IC) 2 Antibodies 2 Antibodies 2 Antibodies
Immunofluorescence (IF) 4 Antibodies 7 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antibodies 13 Antibodies
Immunohistochemistry (IHC) 14 Antibodies 14 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 6 Antibodies 8 Antibodies
Western Blotting (WB) 17 Antibodies 20 Antibodies
Immunocytochemistry (ICC) 3 Antibodies 5 Antibodies
Dot Blot (DB) 11 Antibodies
Enzyme Immunoassay (EIA) 3 Antibodies

General

Antigen Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Antibodies
Epitope AA 370-420, pSer400
(29), (16), (13), (8), (7), (6), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(93), (37), (34), (5), (4), (2), (1), (1)
Host Rabbit
(89), (4)
Clonality
Polyclonal
Conjugate This MAP3K8 antibody is un-conjugated
(5), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(49), (41), (32), (22), (12), (11), (8), (5), (3), (2)
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Product Details anti-MAP3K8 Antibody

Target Details MAP3K8 Application Details Handling Images
Specificity This phosphorylation site is homologous across the listed species.
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human MAP3K8/Tpl2 around the phosphorylation site of Ser400
Isotype IgG

Target Details MAP3K8

Product Details anti-MAP3K8 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Map3k8 (MAP3K8 Antibody Abstract)
Background

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.

Subcellular location: Cytoplasm


Synonyms: COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT, Mitogen-activated protein kinase kinase kinase 8, Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, MAP3K8
Gene ID 1326
UniProt P41279
Research Area Cancer
Pathways PI3K-Akt Signaling, TCR Signaling

Application Details

Product Details anti-MAP3K8 Antibody Target Details MAP3K8 Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-MAP3K8 Antibody Target Details MAP3K8 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-MAP3K8 Antibody Target Details MAP3K8 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-MAP3K8 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 8) (AA 370-420) (ABIN746573) Formalin-fixed and paraffin embedded human colon carcinoma tissue labeled with Anti P...