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anti-Human MAP3K8 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended MAP3K8 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Antibodies
  • MAP3K8
  • COT
  • EST
  • ESTF
  • MEKK8
  • TPL2
  • Tpl-2
  • c-COT
  • Cot
  • Cot/Tpl2
  • Est
  • Estf
  • Tpl2
  • D17TPL2
  • mitogen-activated protein kinase kinase kinase 8
  • MAP3K8
  • map3k8
  • Map3k8
Epitope
AA 140-190
26
16
14
8
5
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
93
45
42
10
8
4
2
2
2
1
1
Host
Rabbit
89
4
Clonality
Polyclonal
Conjugate
This MAP3K8 antibody is un-conjugated
5
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
53
38
31
27
14
10
9
3
3
2
2
Options
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Catalog No. ABIN701275
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN360360 EIA IHC (p) WB Rabbit Ig C-Term Log in to see Polyclonal 5
1 ABIN360298 EIA IHC (p) WB Rabbit Ig C-Term Log in to see Polyclonal 5
1 ABIN265369 IF IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN392472 IHC (p) WB Rabbit Ig AA 368-397, C-Term Log in to see Polyclonal
1 ABIN392412 IHC (p) WB Rabbit Ig AA 414-445, C-Term Log in to see Polyclonal
1 ABIN2855464 ICC IF IHC (p) WB Rabbit IgG Center Log in to see Polyclonal
1 ABIN2855466 ICC IF IHC (p) WB Rabbit IgG Center Log in to see Polyclonal
1 ABIN4886663 IHC (p) WB Rabbit IgG AA 9-193 Log in to see Polyclonal
1 ABIN746573 IF (p) IHC (p) WB Rabbit IgG AA 370-420, pSer400 Log in to see Polyclonal
1 ABIN746588 IF (p) IHC (p) Rabbit IgG AA 270-320, pThr290 Log in to see Polyclonal
1 ABIN1049034 IHC (p) Rabbit C-Term Log in to see Polyclonal
1 ABIN1049035 IHC (p) Rabbit N-Term Log in to see Polyclonal
1 ABIN2888594 IF IHC (p) ELISA WB Rabbit IgG AA 256-305 Log in to see Polyclonal
1 ABIN2889108 IHC (p) ELISA WB Rabbit IgG AA 366-415 Log in to see Polyclonal
1 ABIN1736725 IHC (p) Rabbit IgG C-Term Log in to see Polyclonal
1 ABIN1736726 IHC (p) Rabbit IgG N-Term Log in to see Polyclonal
1 ABIN701284 IHC (p) WB HRP Rabbit IgG AA 140-190 Log in to see Polyclonal
1 ABIN701277 IHC (p) WB Biotin Rabbit IgG AA 140-190 Log in to see Polyclonal
1 ABIN2891359 IF IHC (p) WB Rabbit Pro284 Log in to see Polyclonal
1 ABIN2883655 ELISA IF IHC (p) WB Rabbit IgG pThr290 Log in to see Polyclonal

Top referenced anti-MAP3K8 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-MAP3K8 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine) Human
ELISA 16 Antibodies 15 Antibodies 38 Antibodies
Immunochromatography (IC) 2 Antibodies 2 Antibodies
Immunocytochemistry (ICC) 1 Antibodies 3 Antibodies
Immunofluorescence (IF) 7 Antibodies 9 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 1 Antibodies 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 15 Antibodies 15 Antibodies
Immunohistochemistry (IHC) 13 Antibodies 14 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 13 Antibodies 15 Antibodies
Western Blotting (WB) 24 Antibodies 26 Antibodies
Dot Blot (DB) 10 Antibodies

General

Antigen Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Antibodies
Epitope AA 140-190
(26), (16), (14), (8), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(93), (45), (42), (10), (8), (4), (2), (2), (2), (1), (1)
Host Rabbit
(89), (4)
Clonality
Polyclonal
Conjugate This MAP3K8 antibody is un-conjugated
(5), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(53), (38), (31), (27), (14), (10), (9), (3), (3), (2), (2)
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Product Details anti-MAP3K8 Antibody

Target Details MAP3K8 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human MAP3K8
Isotype IgG

Target Details MAP3K8

Product Details anti-MAP3K8 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Map3k8 (MAP3K8 Antibody Abstract)
Background

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.

Subcellular location: Cytoplasm


Synonyms: COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT, Mitogen-activated protein kinase kinase kinase 8, Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, MAP3K8
Gene ID 1326
UniProt P41279
Research Area Cancer
Pathways PI3K-Akt Signaling, TCR Signaling

Application Details

Product Details anti-MAP3K8 Antibody Target Details MAP3K8 Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-MAP3K8 Antibody Target Details MAP3K8 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-MAP3K8 Antibody Target Details MAP3K8 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-MAP3K8 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 8) (AA 140-190) (ABIN701275) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-MAP3K8/T...
Immunohistochemistry (IHC) image for anti-MAP3K8 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 8) (AA 140-190) (ABIN701275) Formalin-fixed and paraffin embedded mouse lymphoma labeled with Rabbit Anti MAP3K8/T...
SDS-PAGE (SDS) image for anti-MAP3K8 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 8) (AA 140-190) (ABIN701275) Lane 1: rat brain lysates Lane 2: rat heart lysates probed with Anti MAP3K8/TPL2 Poly...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MAP3K8 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 8) (AA 140-190) (ABIN701275) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-MAP3K8/T...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MAP3K8 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 8) (AA 140-190) (ABIN701275) Formalin-fixed and paraffin embedded mouse lymphoma labeled with Rabbit Anti MAP3K8/T...