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Misfolded Frank-ter (show TECR Proteins) Haar syndrome protein Tks4(R43W) is transported via the microtubule system to the aggresomes.
a new function for Tks4 in the regulation of growth factor-dependent cell migration.
SH3PXD2B is a scaffold protein (show HOMER1 Proteins) that plays a key role in regulating the actin cytoskeleton via Src (show SRC Proteins) and cortactin (show CTTN Proteins).
Tks4 and Tks5 directly bind to NoxA1 (show NOXA1 Proteins). The integrity of the N-terminal PRR (show PVRL1 Proteins) of NoxA1 (show NOXA1 Proteins) is essential for this direct interaction with the Tks (show PTK6 Proteins) proteins.
The Nox1 (show NOX1 Proteins)-dependent generation of reactive oxygen species is dependent on Src (show SRC Proteins) phosphorylation of NoxA1 (show NOXA1 Proteins) and Tks4. Blockage of phosphorylation of NoxA1 (show NOXA1 Proteins) and Tks4 decreases Nox1 (show NOX1 Proteins)-dependent ROS (show ROS1 Proteins) generation and blocks SrcYF-induced invadopodia formation.
These findings establish a role for TKS4 in Frank-Ter (show TECR Proteins) Haar syndrome and embryonic development.
eyes of B10-Sh3pxd2bnee mice exhibit multiple features of congenital glaucoma.
The mouse model with a mutation in the Sh3pxd2b gene (Sh3pxd2b(nee)) mirrors craniofacial dysmorphology and otitis media in humans.
SH3PXD2B is a podosomal-adaptor protein required for postnatal growth and development.
Induction of the fad49 gene was observed in adipocyte differentiable 3T3-L1 cells, but not in non-adipogenic NIH-3T3 cells.
Tks4 has a role in the formation and function of podosomes.
Silencing of C/EBPdelta (show CEBPD Proteins) impaired the expression of factor for adipocyte differentiation (fad) 49, which is up-regulated and plays a crucial role early in adipogenesis.
This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome.
SH3 and PX domain-containing protein 2B
, adapter protein HOFI
, adaptor protein HOFI
, factor for adipocyte differentiation 49
, tyrosine kinase substrate with four SH3 domains