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Data indicate that zygotic nup107 mutant embryos show tissue-specific defects with impaired nuclear export of mRNAs.
Nup107 knockdown in somatic gonadal cells resulted in female sterility. Transgenic rescue of Drosophila females bearing the Nup107D364N mutation resulted in almost complete sterility, reduced progeny, aberrant eggshells, and disintegrating egg chambers.
Nup107-160 complex and its partner Elys dynamically colocalize with Nup98 (show NUP98 Proteins) and CRM1 (show XPO1 Proteins) into endogenous GLFG bodies present in specific HeLa sublines.
a recessive missense mutation in nucleoporin-107 (NUP107, c.1339G>A, p.D447N). This mutation segregated with the XX-GD phenotype and was not present in available databases or in 150 healthy ethnically matched controls.
The central domain of Nup107 interfered with Apaf-1 (show APAF1 Proteins) nuclear translocation upon genotoxic stress, resulting in a marked reduction of Chk-1 (show CHEK1 Proteins) activation and cell cycle arrest.
Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome.
The functions have been ascribed to the NUP107 complex, ranging from Nuclear Pore Complex (NPC (show NPC1 Proteins)) assembly to mRNA export to cell differentiation.
Study shows that 32 copies of the Nup107 subcomplex assemble into two reticulated rings, one each at the cytoplasmic and nuclear face of the nuclear pore complex.
The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex.
did a Trypan Blue cell viability assay and it showed increased cell death in NUP107 transfected cells than untreated control
These findings support the notion that Nup107 may contribute significantly to the regulation of cell fate in aged and transformed cells by modulating nuclear trafficking of signal molecules.
A major function of the Nup107 complex in mitosis is to ensure the proper localization of the chromosome passenger complex at the centromere.
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
, nucleoporin 107kDa
, nuclear pore complex protein Nup107
, nuclear pore complex protein nup107
, Nuclear pore complex protein Nup107
, nuclear pore complex protein Nup107-like
, nucleoporin 107
, 107 kDa nucleoporin
, nucleoporin Nup107