Angiopoietin 2 Protein (ANGPT2) (AA 19-496) (DYKDDDDK Tag)
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- Target See all Angiopoietin 2 (ANGPT2) Proteins
- Angiopoietin 2 (ANGPT2)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-496
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Origin
- Human, Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Angiopoietin 2 protein is labelled with DYKDDDDK Tag.
- Application
- SDS-PAGE (SDS)
- Specificity
- Binds to the human and mouse Tie-2 receptor.
- Cross-Reactivity
- Human, Mouse (Murine)
- Characteristics
- Human angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG®-tag.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product ANGPT2 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 100 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS with trehalose and Brij35.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells." in: Cardiovascular research, Vol. 72, Issue 3, pp. 394-402, (2006) (PubMed).
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Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells." in: Cardiovascular research, Vol. 72, Issue 3, pp. 394-402, (2006) (PubMed).
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- Target
- Angiopoietin 2 (ANGPT2)
- Alternative Name
- Angiopoietin-2 (ANGPT2 Products)
- Synonyms
- AGPT2 Protein, ANG2 Protein, Agpt2 Protein, Ang-2 Protein, Ang2 Protein, ang2 Protein, angpt2 Protein, ANGIOPOIETIN-2 Protein, ANG-2 Protein, ANGPT2 Protein, Angrp Protein, Rnase5b Protein, ANG3 Protein, C11orf2 Protein, C11orf3 Protein, FFR Protein, angiopoietin 2 Protein, angiopoietin 2b Protein, angiogenin, ribonuclease A family, member 2 Protein, VPS51, GARP complex subunit Protein, ANGPT2 Protein, Angpt2 Protein, angpt2b Protein, Ang2 Protein, VPS51 Protein
- Background
- Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.
- Molecular Weight
- ~70kDa (SDS-PAGE)
- UniProt
- O15123
- Pathways
- RTK Signaling
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