Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-328) (Active) protein (Fc Tag)

Details for Product No. ABIN2181368, Supplier: Log in to see
Protein Name
  • DER4
  • Fit-1
  • Ly84
  • ST2L
  • St2
  • St2-rs1
  • T1
  • T1/ST2
  • FIT-1
  • IL33R
  • ST2
  • ST2V
  • FIT1
  • interleukin 1 receptor-like 1
  • Il1rl1
  • IL1RL1
Protein Characteristics
AA 19-328
5
4
2
2
1
1
1
1
1
1
Origin
Human
17
7
Source
HEK-293 Cells
6
4
3
2
2
2
1
1
Protein Type
Recombinant
Biological Activity
Active
Purification tag / Conjugate
This IL1RL1 protein is labelled with Fc Tag.
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 61 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity >90 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
ProductDetails: Biological Activity Comment Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL33 at 10 μg/mL (100 μL/well) can bind rh IL1RL1 /ST2 Fc Chimera with a linear range of 0.3-5 μg/mL.

SDS-PAGE: due to glycosylation.
Background Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.
Molecular Weight 61 kDa
NCBI Accession NP_003847
UniProt Q01638
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer 50 mM Tris, 100 mM Glycine, pH 7.5
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Supplier Images
SDS-PAGE (SDS) image for Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-328) (Active) protein (Fc Tag) (ABIN2181368) Human IL-1RL1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained o...
Binding Studies (Bind) image for Interleukin 1 Receptor-Like 1 (IL1RL1) (AA 19-328) (Active) protein (Fc Tag) (ABIN2181368) Immobilized Human IL-33, Tag Free with a linear range of 1.95-7.8 ng/mL.
Background publications Schmitz, Owyang, Oldham, Song, Murphy, McClanahan, Zurawski, Moshrefi, Qin, Li, Gorman, Bazan, Kastelein: "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines." in: Immunity, Vol. 23, Issue 5, pp. 479-90, 2005 (PubMed).

Tago, Noda, Hayakawa, Iwahana, Yanagisawa, Yashiro, Tominaga: "Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V." in: Biochemical and biophysical research communications, Vol. 285, Issue 5, pp. 1377-83, 2001 (PubMed).

Did you look for something else?