Forkhead Box O3 (FOXO3) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)

Details for Product No. ABIN2712289, Supplier: Log in to see
Protein Name
  • FOXO3
  • FKHRL1
  • FOXO3A
  • zgc:92176
  • wu:fb50g02
  • wu:fi33f07
  • foxo3a
  • xfoxo3
  • foxO3
  • foxO
  • AF6q21
  • FKHRL1P2
  • FOXO2
  • 1110048B16Rik
  • 2010203A17Rik
  • C76856
  • Fkhr2
  • Foxo3a
  • FoxO3A
  • Fkhrl1
  • FOXO-3
  • forkhead box O3
  • forkhead box O3A
  • FOXO3
  • foxo3a
  • foxo3
  • foxO3
  • Foxo3
Protein Characteristics
Transcript Variant 1
3
1
1
1
1
1
Origin
Human
7
1
Source
HEK-293 Cells
3
2
1
1
1
Protein Type
Recombinant
Purification tag / Conjugate
This FOXO3 protein is labelled with Myc-DYKDDDDK Tag.
Application
Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
Options
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Specificity Optimal preservation of protein structure, post-translational modifications and functions.
Characteristics
  • Recombinant human FOXO3 / FKHRL1 (transcript variant 1) protein expressed in HEK293 cells.
  • Produced with end-sequenced ORF clone
Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
Background This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
Molecular Weight 71.1 kDa
NCBI Accession NP_001446
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
Application Notes Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays
Comment

The tag is located at the C-terminal.

Restrictions For Research Use only
Concentration > 50 μg/mL
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Storage -80 °C
Storage Comment Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
Supplier Images
Western Blotting (WB) image for Forkhead Box O3 (FOXO3) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag) (ABIN2712289) Validation with Western Blot
Product cited in: Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: "FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 12, pp. 5637-47, 2015 (PubMed).