ALIX Protein (AA 1-392) (His tag)

Catalog No. ABIN666945

Product Details

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Protein Type: Recombinant

Protein Characteristics: AA 1-392

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This ALIX protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: Alix, 1-392aa, Human, His tag, E.coli

Purity: > 95 % by SDS-PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.

Storage: 4 °C

Target Details

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Alternative Name: Alix (PDCD6IP Products)

Synonyms: DDBDRAFT_0167145 Protein, DDBDRAFT_0185177 Protein, DDB_0167145 Protein, DDB_0185177 Protein, AIP1 Protein, ALIX Protein, DRIP4 Protein, HP95 Protein, AI480591 Protein, AW544830 Protein, Aip1 Protein, Alix Protein, C76364 Protein, Eig2 Protein, mKIAA1375 Protein, CG12876 Protein, DAIP1 Protein, Dmel\\CG12876 Protein, GB11744 Protein, RGD1561176 Protein, zgc:63638 Protein, wu:fb70d03 Protein, wu:fy65h02 Protein, PDCD6IP Protein, aip1 Protein, alix Protein, hp95 Protein, drip4 Protein, ALG-2 interacting protein X Protein, programmed cell death 6 interacting protein Protein, programmed cell death 6-interacting protein Protein, Programmed cell death 6 interacting protein Protein, programmed cell death 6 interacting protein L homeolog Protein, alxA Protein, PDCD6IP Protein, Pdcd6ip Protein, ALiX Protein, LOC412662 Protein, pdcd6ip Protein, Bm1_48390 Protein, pdcd6ip.L Protein

Background: Alix, also known as PDCD6IP, is a cytoplasmic protein that interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. It’s involved in concentration and sorting of cargo proteins of the multivesicular body for incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome. Overexpression of this protein and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death. Recombinant PDCD6IP protein was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: AIP1, PDCD6IP, DRIP4, HP95, PDC6I , Programmed cell death 6 interacting protein ALG 2 interacting protein 1, ALG2 interacting protein X, Apoptosis linked gene 2 interacting protein X, Dopamine receptor interacting protein 4, KIAA1375, MGC17003, PDCD6 interacting protein, Programmed cell death 6 interacting protein. NCBI no.: NP_037506

Molecular Weight: 45.8 kDa (412aa), confirmed by MALDI-TOF.

Pathways: p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation