GRB2 Protein (AA 1-217) (His tag)
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- Target See all GRB2 Proteins
- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-217
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This GRB2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- GRB2, 1-217 aa, Human, His-tagged, Recombinant, E.coli
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product GRB2 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- In 20mM Tris-HCl (pH8.0) buffer containing 30% glycerol
- Storage
- 4 °C
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- Target
- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
- Alternative Name
- GRB2 (GRB2 Products)
- Synonyms
- GRB2 Protein, grb2 Protein, AA408164 Protein, Ash Protein, ASH Protein, EGFRBP-GRB2 Protein, Grb3-3 Protein, MST084 Protein, MSTP084 Protein, NCKAP2 Protein, wu:fb18e12 Protein, wu:fb34e06 Protein, zgc:73077 Protein, growth factor receptor bound protein 2 Protein, growth factor receptor-bound protein 2 Protein, growth factor receptor-bound protein 2b Protein, GRB2 Protein, grb2 Protein, Grb2 Protein, grb2b Protein
- Background
- Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. GRB2 is widely expressed and also binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. Recombinant human GRB2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Growth factor receptor-bound protein 2 isoform 1, ASH, EGFRBP-GRB2, GRB3-3, Growth factor receptor-bound protein 2 isoform 1 Abundant SRC homology, Adapter protein GRB2, Ash protein, EGFRBP GRB2, Epidermal growth factor receptor binding protein, Epidermal growth factor receptor binding protein GRB2, GRB 2, GRB2 adapter protein, Grb3 3, Growth factor receptor bound protein 2, Growth factor receptor bound protein 3, HT027, MST084, MSTP084, OTTHUMP00000166096, OTTHUMP00000166097, OTTHUMP00000166098, Protein ASH, SEM5, SH2/SH3 adapter GRB2. NCBI no.: NP_002077
- Molecular Weight
- 27 kDa (237 aa), confirmed by MALDI-TOF.
- Pathways
- RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
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