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HTRA3 antibody (N-Term)

HTRA3 Reactivity: Human, Rat WB, IHC (p) Host: Rabbit Polyclonal RB2322 unconjugated
Catalog No. ABIN1882095
  • Target See all HTRA3 Antibodies
    HTRA3 (HtrA Serine Peptidase 3 (HTRA3))
    Binding Specificity
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 112-144, N-Term
    Reactivity
    • 20
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 19
    • 1
    Rabbit
    Clonality
    • 19
    • 1
    Polyclonal
    Conjugate
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HTRA3 antibody is un-conjugated
    Application
    • 12
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This HtrA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-144 amino acids from the N-terminal region of human HtrA3.
    Clone
    RB2322
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Narkiewicz, Klasa-Mazurkiewicz, Zurawa-Janicka, Skorko-Glonek, Emerich, Lipinska: "Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer." in: Clinical biochemistry, Vol. 41, Issue 7-8, pp. 561-9, (2008) (PubMed).

    Grau, Baldi, Bussani, Tian, Stefanescu, Przybylski, Richards, Jones, Shridhar, Clausen, Ehrmann: "Implications of the serine protease HtrA1 in amyloid precursor protein processing." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 17, pp. 6021-6, (2005) (PubMed).

    Nie, Hampton, Li, Findlay, Salamonsen et al.: "Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and ..." in: The Biochemical journal, Vol. 371, Issue Pt 1, pp. 39-48, (2003) (PubMed).

  • Target
    HTRA3 (HtrA Serine Peptidase 3 (HTRA3))
    Alternative Name
    HtrA3 (HTRA3 Products)
    Synonyms
    HTRA3 antibody, Prsp antibody, Tasp antibody, 2210021K23Rik antibody, 9530081K03Rik antibody, RGD1308120 antibody, Trypsin-like serine protease antibody, HtrA serine peptidase 3 antibody, htrA3 antibody, HTRA3 antibody, Htra3 antibody
    Background
    Insulin-like growth factors (IGFs) stimulate the proliferation and differentiation of a vast number of cell types. The action of the growth factors is mediated and controlled by a complex system of components, including several proteases that cleave the IGF-Binding Proteins. HtrA1 is a 480 aa protein that contains an N-terminus homologous to MAC25 (IGFBP7) with a conserved Kazal-type serine protease inhibitor motif, as well as a C-terminal PDZ domain. Semiquantitative RT-PCR and immunoblot analyses showed an approximately 7-fold increase of PRSS11 in osteoarthritis cartilage compared with controls. HTRA2 is released from mitochondria and inhibits the function of XIAP by direct binding in a way similar to SMAC. Moreover, when overexpressed extramitochondrially, HTRA2 induced atypical cell death, which was neither accompanied by a significant increase in caspase activity nor inhibited by caspase inhibitors, including XIAP. A catalytically inactive mutant of HTRA2, however, did not induce cell death. Suzuki et al. (2001) concluded that HTRA2 is a SMAC-like inhibitor of IAP (inhibitor of apoptosis proteins) activity with a serine protease-dependent cell death-inducing activity.
    Molecular Weight
    48608
    NCBI Accession
    NP_444272
    UniProt
    P83110
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