Toxin A (AA 2123-2132) antibody

Catalog No. ABIN2476899

Product Details

Target: Toxin A

Binding Specificity: AA 2123-2132

Reactivity: Clostridium difficile

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA

Specificity: This antibody is specific for Clostridium difficile Toxin A, a gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density, and the administration of antibiotics. Toxin A (TcdA) is a large exotoxin which is an essential virulence factor for C. difficile infection. TcdA has a molecular weight of 308kD and is a glucosyltransferase, which irreversibly inactivates the Ras family of small GTPases to disrupt many important signalling pathways.

Characteristics: Purified IgG

Purification: Purified

Immunogen: Synthetic peptide corresponding to the amino acids 2123-2132 of the native molecule conjugated to Keyhole limpet Haemocyanin. Peptide sequence: CTIDGKKYYFN

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 5.0 mg/mL

References

Voth, Ballard: "Clostridium difficile toxins: mechanism of action and role in disease." in: Clinical microbiology reviews, Vol. 18, Issue 2, pp. 247-63, (2005) (PubMed).

Target Details

Target: Toxin A

UniProt: P16154