Toxin A antibody

Catalog No. ABIN335169

Product Details

Target: Toxin A

Reactivity: Clostridium difficile

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Specificity: Antibody recognises TcdA in general

Purification: The antibody was purified by protein A from cell culture supernatants and is routinely tested

Immunogen: was generated by immunisation of mice with toxin and toxin fragments

Application Details

Restrictions: For Research Use only

Handling

Concentration: 3 mg/ml

Buffer: PBS

Storage: 4 °C

References

Leslie, Vendrov, Jenior, Young: "The Gut Microbiota Is Associated with Clearance of Clostridium difficile Infection Independent of Adaptive Immunity." in: mSphere, Vol. 4, Issue 1, (2019) (PubMed).

Quesada-Gómez, López-Ureña, Chumbler, Kroh, Castro-Peña, Rodríguez, Orozco-Aguilar, González-Camacho, Rucavado, Guzmán-Verri, Lawley, Lacy, Chaves-Olarte: "Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities." in: Infection and immunity, Vol. 84, Issue 3, pp. 856-65, (2016) (PubMed).

Costa, López-Ureña, de Oliveira Assis, Ribeiro, Silva, Rupnik, Wilcox, de Carvalho, do Carmo, Dias, de Carvalho, Chaves-Olarte, Rodríguez, Quesada-Gómez, de Castro Brito: "A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption." in: Anaerobe, Vol. 40, pp. 76-84, (2016) (PubMed).

Quesada-Gómez, López-Ureña, Acuña-Amador, Villalobos-Zúñiga, Du, Freire, Guzmán-Verri, del Mar Gamboa-Coronado, Lawley, Moreno, Mulvey, de Castro Brito, Rodríguez-Cavallini, Rodríguez, Chaves-Olarte: "Emergence of an outbreak-associated Clostridium difficile variant with increased virulence." in: Journal of clinical microbiology, Vol. 53, Issue 4, pp. 1216-26, (2015) (PubMed).

Wullt, Norén, Ljungh, Åkerlund: "IgG antibody response to toxins A and B in patients with Clostridium difficile infection." in: Clinical and vaccine immunology : CVI, Vol. 19, Issue 9, pp. 1552-4, (2012) (PubMed).

Kuehne, Cartman, Heap, Kelly, Cockayne, Minton: "The role of toxin A and toxin B in Clostridium difficile infection." in: Nature, Vol. 467, Issue 7316, pp. 711-3, (2010) (PubMed).

Target Details

Target: Toxin A