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Browse our anti-LATS1 (LATS1) Antibodies

Full name:
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) Antibodies (LATS1)
On www.antibodies-online.com are 77 LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) Antibodies from 16 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 87 LATS1 products are currently listed.
Synonyms:
AW208599, Lats, lats1, RGD1564085, si:dkey-181i3.5, WARTS, wts, wu:fc19a11, zgc:123219
list all antibodies Gene Name GeneID UniProt
LATS1 16798 Q8BYR2
LATS1 9113 O95835
LATS1 308265  

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Most Popular Reactivities for anti-LATS1 (LATS1) Antibodies

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anti-Mouse (Murine) LATS1 Antibodies:

anti-Human LATS1 Antibodies:

anti-Rat (Rattus) LATS1 Antibodies:

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Top referenced anti-LATS1 Antibodies

  1. Human Polyclonal LATS1 Primary Antibody for IHC (p), WB - ABIN391033 : Iida, Hirota, Morisaki, Marumoto, Hara, Kuninaka, Honda, Kosai, Kawasuji, Pallas, Saya: Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. in Oncogene 2004 (PubMed)
    Show all 6 references for ABIN391033

  2. Cow (Bovine) Polyclonal LATS1 Primary Antibody for WB - ABIN2787626 : Zhang, Smolen, Haber: Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. in Cancer research 2008 (PubMed)

  3. Human Polyclonal LATS1 Primary Antibody for IF (p), IHC (p) - ABIN872292 : Grijalva, Huizenga, Mueller, Rodriguez, Brazzo, Camargo, Sadri-Vakili, Vakili: Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration. in American journal of physiology. Gastrointestinal and liver physiology 2014 (PubMed)

  4. Human Polyclonal LATS1 Primary Antibody for IP, WB - ABIN4891893 : Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. in Oncotarget 2015 (PubMed)

  5. Human Polyclonal LATS1 Primary Antibody for EIA, IHC (p) - ABIN359091 : Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. in Blood 2008 (PubMed)

More Antibodies against LATS1 Interaction Partners

Zebrafish LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. Thus AMOT (show AMOT Antibodies) is a direct substrate of Lats1/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.

  2. lats genes show distinctly different expression profiles during gastrulation. lats1 is almost ubiquitously expressed through development, and lats2 (show LATS2 Antibodies) is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula.

Mouse (Murine) LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. Study demonstrates that, in 3 different murine syngeneic tumor models (B16, SCC7, and 4T1), loss of the Hippo pathway kinases LATS1/2 (large tumor suppressor 1 and 2) in tumor cells inhibits tumor growth; data indicate a new paradigm for how tumor immunogenicity is regulated through the Hippo signaling pathway in tumor cells.

  2. Results showed that the Hippo pathway is active in ovarian follicles and that LATS1 is required to maintain the pool of germ cells and primordial follicles.

  3. The control of LATS activation by angiotensin II and subsequent YAP (show YAP1 Antibodies) localization is important for podocyte homeostasis and survival.

  4. Willin (show FRMD6 Antibodies) is predominantly expressed in fibroblasts and that Willin (show FRMD6 Antibodies) expression activates the Hippo signaling cascade

  5. LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization.

  6. KIBRA (show WWC1 Antibodies) associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif

  7. Lats1 enhances the activity of FOXl2 (show FOXL2 Antibodies) as a repressor of the StAr promoter. st

  8. Overexpression of YAP2 (show YAP1 Antibodies) in cells promoted apoptosis, whereas the Mst2 (show STK3 Antibodies)/Lats1-induced phosphorylation of YAP (show YAP1 Antibodies) partially rescued the cells from apoptotic death.

  9. Genome-wide location arrays in cell lines of various cell types revealed that Lats1 was a transcriptional target of CUX1 (show CUX1 Antibodies).

Human LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) interaction partners

  1. A group of miRNAs have been demonstrated to directly target components of the Hippo signaling pathway, such as YAP (show YAP1 Antibodies), TAZ (show TAZ Antibodies) and LATS1/2 in oncogenesis. (Review)

  2. findings reveal a non-canonical (that is, YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies)-independent) effect of LATS in the regulation of human breast cell fate

  3. AGO2 (show EIF2C2 Antibodies) immunoprecipitation revealed LATS1 as a novel proapoptotic target of miR (show MLXIP Antibodies)-21 in T cells.

  4. LATS1 was downregulated in cervical cancer and may suppress cell growth and invasion through regulating the expression of cyclin E (show CCNE1 Antibodies), p27 (show PAK2 Antibodies), MMP9 (show MMP9 Antibodies) and YAP (show YAP1 Antibodies).

  5. PARD3 (show PARD3 Antibodies) promotes interaction between PP1A (show PPP1CA Antibodies) and LATS1 to induce LATS1 dephosphorylation and inactivation,leading to dephosphorylation and activation of TAZ (show TAZ Antibodies)

  6. Loss of LATS1 expression is associated with breast neoplasms.

  7. Phosphorylation of CHO1 (show KIF23 Antibodies) at S716 by Lats1 regulate its centrosomal localization, and that phosphorylated CHO1 (show KIF23 Antibodies) interacts with and activates LIMK1 (show LIMK1 Antibodies) during early mitosis.

  8. LATS1 phosphorylates the Thr7 residue of the APC (show APC Antibodies)/C component CDC26 (show CDC26 Antibodies) directly

  9. These results demonstrated that as an inhibitor of YAP (show YAP1 Antibodies), LATS1 was decreased via downregulation of YAP (show YAP1 Antibodies) using RNAi. This therefore indicated that the change in YAP (show YAP1 Antibodies) levels in hepatocellular carcinoma cells may regulate LATS1 in a feedback manner.

  10. LATS1 promoter hypermethylation is associated with oral squamous cell carcinomas.

LATS1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Alternative names and synonyms associated with LATS1

  • LATS, large tumor suppressor, homolog 1 (Drosophila) (LATS1) antibody
  • LATS, large tumor suppressor, homolog 1 (Drosophila) (lats1) antibody
  • LATS, large tumor suppressor, homolog 1 (TEgg117h14.1) antibody
  • large tumor suppressor (Lats1) antibody
  • large tumor suppressor kinase 1 (LATS1) antibody
  • large tumor suppressor kinase 1 (Lats1) antibody
  • AW208599 antibody
  • Lats antibody
  • lats1 antibody
  • RGD1564085 antibody
  • si:dkey-181i3.5 antibody
  • WARTS antibody
  • wts antibody
  • wu:fc19a11 antibody
  • zgc:123219 antibody

Protein level used designations for LATS1

large tumor suppressor , serine/threonine-protein kinase LATS1 , LATS homolog 1 , LATS, large tumor suppressor, homolog 1 , LATS, large tumor suppressor, homolog 1 (Drosophila) , serine/threonine-protein kinase LATS1-like , WARTS protein kinase , large tumor suppressor homolog 1 , large tumor supressor, homolog 1 , LATS (large tumor suppressor, Drosophila) homolog 1 , h-warts , large tumor suppressor 1

GENE ID SPECIES
100060397 Equus caballus
553164 Danio rerio
748397 Pan troglodytes
100145677 Xenopus (Silurana) tropicalis
100410314 Callithrix jacchus
100455398 Pongo abelii
100467078 Ailuropoda melanoleuca
100539393 Meleagris gallopavo
100599863 Nomascus leucogenys
16798 Mus musculus
9113 Homo sapiens
308265 Rattus norvegicus
421627 Gallus gallus
100152165 Sus scrofa
535935 Bos taurus
476241 Canis lupus familiaris
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