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Results show that deleted in colorectal cancer receptors contribute to the dynamic refinement of dopamine D1 and D2 receptor (show DRD2 ELISA Kits) expression in striatal regions across adolescence. The age-dependent expression of dopamine receptor in C57BL6 mice shows marked differences from previous characterizations in rats.
abrogated ABCC6 (show ABCC6 ELISA Kits) function does cause alterations in the metabolic profile of the liver in accordance with PXE (show ABCC6 ELISA Kits) being a metabolic disease originating from liver disturbance
Results suggest that Netrin1/DCC signaling induce neuronal migration in the dorsal spinal cord.
Results suggest that Dcc plays an important role in the developmental formation of peripheral and central auditory circuits, and its mutation may contribute to sensorineural hearing loss.
dcc haploinsufficient mice acquire intracranial self-stimulation behavior and that the parameters of the stimulation are comparable to those observed in wild-type littermates; reduced expression of dcc may dampen the abuse potential of cocaine
Identified the Dcc gene as a novel downstream target of spontaneous calcium activity involved in axon growth.
bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 (show ABCC6 ELISA Kits) gene.
suggest that DCC signaling functions through NCK1 and NCK2 and that both proteins are necessary for the establishment of normal spinal circuits necessary for gait
Results suggest that down syndrome cell adhesion molecule (show DSCAM ELISA Kits) collaborates with deleted in colorectal cancer to regulate microtubule dynamics via direct binding to dynamic TUBB3 (show TUBB3 ELISA Kits) in Netrin-1 (show NTN1 ELISA Kits)-induced axon branching.
In a mouse model of CKD, ABCC6 (show ABCC6 ELISA Kits) protein expression was decreased in liver and kidney, however mRNA levels were unchanged.
Schwann cell and dcc-mediated guidance are critical early during regeneration to direct growth cones across the transection gap and onto their original axonal trajectory.
in dcc mutants, turns on the inappropriate side of the body are caused by aberrant ipsilateral axonal projections
Dcc-Netrin1 and roundabout2 (Robo2)-Slit coordinate axonal projection choices of neurons in the developing forebrain.
Dcc regulates polarized axon initiation and asymmetric outgrowth of forebrain neurons
dcc may play roles not only in axon guidance, but in morphogenesis and functioning of these organs as well
First evidence that Netrin/DCC axon guidance molecules act in dendrites in a vertebrate system.
ESCRT-II (show VPS28 ELISA Kits)-mediated endocytic pathway regulates both DCC and local protein synthesis.
Environmental and endogenous proteases may contribute to cancer development by depleting DCC and neogenin (show NEO1 ELISA Kits).
Identified DCC mutations in four families.
DCC polymorphism maybe responsible for successful treatment of patients with hydrochlorothiazide . diagnosed with hypertension.
Deleted in colorectal cancer (DCC) confers susceptibility to depression-like behaviors in humans and mice and Is regulated by miR (show MLXIP ELISA Kits)-218. By regulating DCC, miR (show MLXIP ELISA Kits)-218 may be a switch of susceptibility versus resilience to stress-related disorders.
DCC/18q and ERBB2 (show ERBB2 ELISA Kits)/17q gene copy number variations are associated with disease-free survival in microsatellite stable colon cancer
Allelic and genotypic frequencies of the DCC polymorphism rs2229080 were nominally associated with schizophrenia.
Results of APC and DCC LOH, KRAS and microsatellite instability indicate our colorectal cancer cases were typical of sporadic cancers following the 'chromosomal instability' pathway.
The study identified DCC as a differentially expressed gene and clustered meningiomas into DCC low expression (3 grade I and 3 grade II tumors), DCC medium expression (2 grade I and 1 grade II tumors), and DCC high expression (5 grade I tumors) groups.
Data suggest that, in response to netrin-1 (show NTN1 ELISA Kits)/netrin receptor (DCC) signaling, p120RasGAP (show RASA1 ELISA Kits) is recruited to growth cones and supports axon outgrowth; p120RasGAP (show RASA1 ELISA Kits) Src (show SRC ELISA Kits) homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth.
By analyzing multiple myeloma-derived cell lines and patient-derived primary CD138 (show SDC1 ELISA Kits)-positive plasma cells ... authors show for the first time that transcriptional dysregulation of DCC is involved in the progression of plasma cell malignancy.
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
ATP-binding cassette sub-family C member 6
, ATP-binding cassette, sub-family C, member 6
, multidrug resistance-associated protein 6
, multidrug resistance-associated protein-6
, deleted in colorectal carcinoma
, netrin receptor DCC
, deleted in colorectal cancer
, deleted in colorectal cancer tumor suppressor
, netrin receptor DCC-like
, colorectal cancer suppressor
, colorectal tumor suppressor
, deleted in colorectal cancer protein
, immunoglobulin superfamily DCC subclass member 1
, immunoglobulin superfamily, DCC subclass, member 1
, tumor suppressor protein DCC