Browse our Neuropilin 1 Proteins (NRP1)

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Neuropilin 1 Proteins (NRP1)
On www.antibodies-online.com are 37 Neuropilin 1 (NRP1) Proteins from 8 different suppliers available. Additionally we are shipping Neuropilin 1 Antibodies (285) and Neuropilin 1 Kits (45) and many more products for this protein. A total of 386 Neuropilin 1 products are currently listed.
Synonyms:
BDCA4, C530029I03, CD304, neuropilin, NP-1, NP1, NPN-1, Npn1, Nrp, nrp-1, NRP1, VEGF165R
list all proteins Gene Name GeneID UniProt
NRP1 8829 O14786
NRP1 18186 P97333
NRP1 246331 Q9QWJ9

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Neuropilin 1 Proteins (NRP1) by Origin

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Top referenced Neuropilin 1 Proteins

  1. Human Neuropilin 1 Protein expressed in Human Cells - ABIN2001892 : He, Tessier-Lavigne: Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. in Cell 1997 (PubMed)
    Show all 7 references for 2001892

  2. Human Neuropilin 1 Protein expressed in Human Cells - ABIN2001890 : Soker, Takashima, Miao, Neufeld, Klagsbrun: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. in Cell 1998 (PubMed)
    Show all 5 references for 2001890

  3. Cynomolgus Neuropilin 1 Protein expressed in Human Cells - ABIN2010114 : Schuch, Machluf, Bartsch, Nomi, Richard, Atala, Soker: In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin-1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo. in Blood 2002 (PubMed)
    Show all 5 references for 2010114

  4. Human Neuropilin 1 Protein expressed in HEK-293 Cells - ABIN2181550 : Tamagnone, Artigiani, Chen, He, Ming, Song, Chedotal, Winberg, Goodman, Poo, Tessier-Lavigne, Comoglio: Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. in Cell 1999 (PubMed)
    Show all 2 references for 2181550

More Proteins for Neuropilin 1 Interaction Partners

Human Neuropilin 1 (NRP1) interaction partners

  1. Data provide evidence that NRP1 (show NELL1 Proteins) functions to enhance the metastatic potential of prostate tumors.

  2. NRP1 (show NELL1 Proteins) is an important niche component

  3. our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1 (show NELL1 Proteins)-dependent VEGFR (show KDR Proteins) signaling in PDA cells.

  4. Our findings identify aberrant active integrin b1-driven Src (show SRC Proteins)-Akt (show AKT1 Proteins) hyperactivation as a primary resistance mechanism to cetuximab in PDAC cells and offer an effective therapeutic strategy to overcome this resistance using an EGFR (show EGFR Proteins) and NRP1 (show NELL1 Proteins) dual targeting antibody

  5. VEGF-A (show VEGFA Proteins) acts via interaction with NRP-1 (show NELL1 Proteins) to trigger intracellular events leading to ECS cell survival and formation of aggressive, invasive and highly vascularized tumors.

  6. These data identify a new molecular mechanism of brain microvascular endothelial inflammatory response through NRP1 (show NELL1 Proteins)-IFNgamma crosstalk.

  7. This study indicates that capsaicin application results in significant loss of epidermal NRP-1 (show NELL1 Proteins) receptor expression, whereas diabetic subjects presenting small fiber neuropathy show full epidermal NRP-1 (show NELL1 Proteins) expression in contrast to the basal expression pattern seen in healthy controls

  8. Study show that a high percentage of intratumoral NRP1 (show NELL1 Proteins)(+) Tregs correlates with poor prognosis in melanoma and head and neck squamous cell carcinoma.

  9. Study revels the structural description of the neuropilin-1 ectopic region by reporting the crystal structure of its MAM domain. The domain adopts a jellyroll fold that is stabilized by a Ca2 (show CA2 Proteins)+ ion while forming a molecular surface that is distinct from its structural homologs.

  10. Data suggest that neuropilin-1 (NRP1) functions as a receptor for neutrophil elastase (NE (show ELANE Proteins)), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (show TMEM37 Proteins) (a peptide fragment of NE) in breast cancer cells.

Mouse (Murine) Neuropilin 1 (NRP1) interaction partners

  1. findings identify a dual function of NRP1 in both axon guidance and subcellular target recognition in the construction of GABAergic circuitry.

  2. Ectopic midline vascularisation in endothelial Nrp1 and Vegfa (show VEGFA Proteins)(188/188) mutants caused additional axonal exclusion zones within the chiasm.

  3. Data suggest that Nrp1 (neuropilin-1) regulates Hedgehog (show SHH Proteins) signaling specifically at the level of activation of GLI2 transcriptional activator function; Nrp1 localization to primary cilium does not correlate with Hedgehog (show SHH Proteins) signal promotion. These studies were conducted in various cell types. (GLI2 = GLI-Kruppel family member GLI2 protein)

  4. These studies reported that myeloid cell-specific Nrp1-deficient mice exhibited enhanced susceptibility to cecal ligation and puncture- and LPS (show TLR4 Proteins)-induced sepsis, which correlated with significantly decreased survival rates and heightened levels of proinflammatory cytokines in both peritoneal lavage and serum.

  5. our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1-dependent VEGFR (show KDR Proteins) signaling in PDA cells.

  6. VEGF165-induced vascular leakage requires both VEGFR2 (show KDR Proteins) and NRP1, including the VEGF164 (show VEGFA Proteins)-binding site of NRP1 and the NRP1 cytoplasmic domain (NCD), but not the known NCD interactor GIPC1 (show GIPC1 Proteins).

  7. demonstrate that NRP-1 is necessary for VEGF (show VEGFA Proteins) to inhibit bone marrow-derived DC (BMDC) maturation; further demonstrate that NRP-1 associates with TLR4 (show TLR4 Proteins), but not VEGFR2 (show KDR Proteins), in a VEGF (show VEGFA Proteins)-dependent manner, and abrogates TLR signaling; results reveal a novel role for NRP-1 in DC physiology and identify NRP-1 as a target to manipulate BMDC maturation

  8. The aim was to elucidate whether ectopic muscles are a result of misguidance of myoblast precursors due to the loss of Sema3A (show SEMA3A Proteins)-Npn-1 signaling.

  9. These data identify a new molecular mechanism of brain microvascular endothelial inflammatory response through NRP1-IFNgamma crosstalk.

  10. IL-10 (show IL10 Proteins) abrogation efficiently induces regulatory T cell (Treg) formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which simultaneously augments Th1 (show HAND1 Proteins) and Th17 immunity.

Xenopus laevis Neuropilin 1 (NRP1) interaction partners

  1. Hermes (show RBPMS Proteins) negatively controls the translation of the guidance cue receptor Neuropilin-1 in retinal ganglion cells

  2. Neuropilin-1 and its co-receptor plexinA1 (show PLXNA1 Proteins) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.

Pig (Porcine) Neuropilin 1 (NRP1) interaction partners

  1. binding of Neuropilin-1 to VEGFR-2 (show KDR Proteins) requires the PDZ-binding domain of neuropilin-1

  2. Neuropilin-1 is essential for enhanced VEGF(165)-mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs.

Neuropilin 1 (NRP1) Protein Profile

Protein Summary

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors\; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Alternative names and synonyms associated with Neuropilin 1 (NRP1)

  • neuropilin 1 (NRP1)
  • neuropilin 1 (nrp1)
  • neuropilin 1 (Nrp1)
  • BDCA4 protein
  • C530029I03 protein
  • CD304 protein
  • neuropilin protein
  • NP-1 protein
  • NP1 protein
  • NPN-1 protein
  • Npn1 protein
  • Nrp protein
  • nrp-1 protein
  • NRP1 protein
  • VEGF165R protein

Protein level used designations for Neuropilin 1 Proteins (NRP1)

neuropilin 1 , neuropilin-1 , A5 antigen , transmembrane receptor , vascular endothelial cell growth factor 165 receptor , A5 protein , Neuropilin-1 precursor (A5 protein) , A5-protein

GENE ID SPECIES
450397 Pan troglodytes
539369 Bos taurus
100101701 Xenopus (Silurana) tropicalis
100171901 Pongo abelii
8829 Homo sapiens
18186 Mus musculus
246331 Rattus norvegicus
395560 Gallus gallus
477955 Canis lupus familiaris
397804 Xenopus laevis
100286859 Sus scrofa
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