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Browse our Cardiotrophin-Like Cytokine Factor 1 Proteins (CLCF1)

Full name:
Cardiotrophin-Like Cytokine Factor 1 Proteins (CLCF1)
On www.antibodies-online.com are 18 Cardiotrophin-Like Cytokine Factor 1 (CLCF1) Proteins from 10 different suppliers available. Additionally we are shipping Cardiotrophin-Like Cytokine Factor 1 Kits (47) and Cardiotrophin-Like Cytokine Factor 1 Antibodies (47) and many more products for this protein. A total of 115 Cardiotrophin-Like Cytokine Factor 1 products are currently listed.
Synonyms:
BSF-3, Bsf3, CISS2, Clc, CLCF1, NNT-1, NNT1, NR6
list all proteins Gene Name GeneID UniProt
CLCF1 23529 Q9UBD9
CLCF1 56708 Q9QZM3
Rat CLCF1 CLCF1 365395  

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Cardiotrophin-Like Cytokine Factor 1 Proteins (CLCF1) by Origin

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Top referenced Cardiotrophin-Like Cytokine Factor 1 Proteins

  1. Human CLCF1 Protein expressed in Escherichia coli (E. coli) - ABIN2666480 : Lelièvre, Plun-Favreau, Chevalier, Froger, Guillet, Elson, Gauchat, Gascan et al.: Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor ... in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN2666480

  2. Human CLCF1 Protein expressed in Escherichia coli (E. coli) - ABIN667531 : Shi, Wang, Yourey, Gohari, Zukauskas, Zhang, Ruben, Alderson: Computational EST database analysis identifies a novel member of the neuropoietic cytokine family. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 2 references for ABIN667531

More Proteins for Cardiotrophin-Like Cytokine Factor 1 Interaction Partners

Human Cardiotrophin-Like Cytokine Factor 1 (CLCF1) interaction partners

  1. CLF-1 (show CRLF1 Proteins), based on its binding site for CLC (show CLC Proteins) and on two additional and independent sites for CNTFRalpha (show CNTFR Proteins) and sorLA (show SORL1 Proteins), is a key player in CLC (show CLC Proteins) and CNTFRalpha (show CNTFR Proteins) signaling and turnover.

  2. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP (show CTF2 Proteins)) signalling and their roles in development, adulthood, cancer and degenerative disorders.

  3. albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 (show CRLF1 Proteins) complex.

  4. activation of the Jak (show JAK3 Proteins)-STAT (show STAT1 Proteins) cascade is essential for corticotroph NNT-1/BSF-3 signaling.

  5. Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC (show CLC Proteins) and CNTFRalpha (show CNTFR Proteins).

  6. Ciliary neurotrophic factor (show CNTF Proteins), cardiotrophin-like cytokine, and neuropoietin (show CTF2 Proteins) share a conserved binding site on the ciliary neurotrophic factor receptor alpha (show CNTFR Proteins) chain (show FCGRT Proteins)

Mouse (Murine) Cardiotrophin-Like Cytokine Factor 1 (CLCF1) interaction partners

  1. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP (show CTF2 Proteins)) signalling and their roles in development, adulthood, cancer and degenerative disorders.

  2. CLC (show CLC Proteins) plays a role in astrocyte differentiation via STAT3 (show STAT3 Proteins) activation within the developing brain

  3. neurotrophin-1/B-cell stimulating factor 3(NNT-1/BSF-3) is expressed in pituitary folliculostellate TtT/GF cells and induced by PKC-, PKA-, and ERK1/2-dependent mechanisms

  4. IL-6 (show IL6 Proteins) (gp130 (show LRPPRC Proteins)) family cytokine members include CLC/NNT1/BSF3 and IL-27 (show IL27 Proteins) [review]

  5. In this study, Clc (show CLC Proteins) knockout mice had decreased facial motility, did not suckle, died within 24 hours, and had 32% and 29% fewer motor neurons in the facial nucleus and lumbar ventral horn, respectively.

Cardiotrophin-Like Cytokine Factor 1 (CLCF1) Protein Profile

Protein Summary

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with Cardiotrophin-Like Cytokine Factor 1 (CLCF1)

  • cardiotrophin-like cytokine factor 1 (clcf1)
  • cardiotrophin-like cytokine factor 1 (CLCF1)
  • cardiotrophin-like cytokine factor 1 (Clcf1)
  • BSF-3 protein
  • Bsf3 protein
  • CISS2 protein
  • Clc protein
  • CLCF1 protein
  • NNT-1 protein
  • NNT1 protein
  • NR6 protein

Protein level used designations for CLCF1

cardiotrophin-like cytokine factor 1 , B-cell stimulating factor 3 , B-cell stimulatory factor 3 , B-cell-stimulating factor 3 , CRLF1 associated cytokine-like factor 1 , neurotrophin-1/B-cell stimulating factor-3 , novel neurotrophin-1 , BSF-3 , NNT-1 , NNT-1/BSF-3 , b cell-stimulating factor 3 , cardiotrophin-like cytokine

GENE ID SPECIES
548821 Xenopus (Silurana) tropicalis
712554 Macaca mulatta
23529 Homo sapiens
56708 Mus musculus
365395 Rattus norvegicus
100721145 Cavia porcellus
483697 Canis lupus familiaris
100336481 Bos taurus
100858060 Gallus gallus
101108788 Ovis aries
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