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Human Monoclonal HLAC Primary Antibody for CyTOF, FACS - ABIN4220954
Apps, Qi, Carlson, Chen, Gao, Thomas, Yuki, Del Prete, Goulder, Brumme, Brumme, John, Mallal, Nelson, Bosch, Heckerman, Stein, Soderberg, Moody, Denny, Zeng, Fang, Moffett, Lifson, Goedert et al.: Influence of HLA-C expression level on HIV control. ... in Science (New York, N.Y.) 2013
Show all 3 Pubmed References
Data establish the C2 allele as a novel genetic risk factor associated with congenital heart block. This observation supports a model in which fetuses with C2 ligand expression and maternal anti-SSA/Ro (show TROVE2 Antibodies) positivity may have impaired NK cell surveillance, resulting in unchecked cardiac inflammation and scarring.
results provide the structural basis for understanding peptide repertoire selection in HLA-C*06:02.
Single-nucleotide polymorphisms FOXF1 rs9936833 and MHC rs9257809 remained significantly associated with presence of gastroesophageal acid reflux. The association for risk allele C in FOXF1 rs9936833 and risk allele A in MHC rs9257809 with the presence of acid reflux suggests a potential pathophysiologic mechanism for the role of genetic influences in Barret Esophagus development.
The minor alleles of rs2395029, rs9264942, and rs3689068 in the HCP5 and HLA-C, and ZNRD1 (show ZNRD1 Antibodies) genes associate with lower viral loads (VL) among antiretroviral-naive individuals and with shorter time to first VL less 51 copies/ml during anti-HIV therapy.
HLA-C*04:01 predisposes to nevirapine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in , but not to other hypersensitivity phenotypes in a sub-Saharan African HIV-infected population
The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype.
Genotyping analysis revealed that HLA-C2, which provides a ligand for killer-cell immunoglobulin-like receptors (KIR (show GEM Antibodies)) expressed by NK cells, was strongly associated with psoriasis susceptibility. However, no link between the KIR (show GEM Antibodies) genes themselves and disease was found
the signal overall signal that NK cells receive from paternal HLA-C on trophoblasts depends on the ratio of activating and inhibitory KIR (show GEM Antibodies) genes expressed by them
Here we define the nature and extent of the variation in 3,489 HLA-A, 4,356 HLA-B and 3,111 HLA-C alleles. The common alleles of human populations comprise 42 core alleles, which represent all selected polymorphism, and recombinants that have assorted this polymorphism
Data suggest that the immunoproteasome is involved in pathologic MHC class I (HLA-A, B, C, F and G) expression and maintenance of myokine production in Idiopathic inflammatory myopathies (IIMs).
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
HLA class I histocompatibility antigen, C alpha chain
, HLA class I histocompatibility antigen, Cw-1 alpha chain
, MHC class I antigen heavy chain HLA-C
, human leukocyte antigen-C alpha chain
, major histocompatibility antigen HLA-C