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Browse our Hepatitis A Virus Cellular Receptor 2 Proteins (HAVCR2)

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Hepatitis A Virus Cellular Receptor 2 Proteins (HAVCR2)
On are 36 Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Proteins from 12 different suppliers available. Additionally we are shipping Hepatitis A Virus Cellular Receptor 2 Antibodies (199) and Hepatitis A Virus Cellular Receptor 2 Kits (7) and many more products for this protein. A total of 256 Hepatitis A Virus Cellular Receptor 2 products are currently listed.
HAVcr-2, HAVCR2, KIM-3, MGC140131, TIM-3, tim3, TIMD-3, Timd3
list all proteins Gene Name GeneID UniProt
HAVCR2 84868 Q8TDQ0
HAVCR2 171285 Q8VIM0
HAVCR2 363578  

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Hepatitis A Virus Cellular Receptor 2 Proteins (HAVCR2) by Origin

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Top referenced Hepatitis A Virus Cellular Receptor 2 Proteins

  1. Human HAVCR2 Protein expressed in HEK-293 Cells - ABIN2181817 : Monney, Sabatos, Gaglia, Ryu, Waldner, Chernova, Manning, Greenfield, Coyle, Sobel, Freeman, Kuchroo: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. in Nature 2002 (PubMed)
    Show all 5 references for ABIN2181817

  2. Human HAVCR2 Protein expressed in Human Cells - ABIN2002756 : Sabatos, Chakravarti, Cha, Schubart, Sánchez-Fueyo, Zheng, Coyle, Strom, Freeman, Kuchroo: Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. in Nature immunology 2003 (PubMed)
    Show all 5 references for ABIN2002756

  3. Cynomolgus HAVCR2 Protein expressed in Human Cells - ABIN2010140 : Zhu, Anderson, Schubart, Xiong, Imitola, Khoury, Zheng, Strom, Kuchroo: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. in Nature immunology 2005 (PubMed)
    Show all 5 references for ABIN2010140

  4. Mouse (Murine) HAVCR2 Protein expressed in Human Cells - ABIN2008706 : Koguchi, Anderson, Yang, OConnor, Kuchroo, Hafler: Dysregulated T cell expression of TIM3 in multiple sclerosis. in The Journal of experimental medicine 2006 (PubMed)
    Show all 5 references for ABIN2008706

  5. Human HAVCR2 Protein expressed in Escherichia coli (E. coli) - ABIN1098725 : Sánchez-Fueyo, Tian, Picarella, Domenig, Zheng, Sabatos, Manlongat, Bender, Kamradt, Kuchroo, Gutiérrez-Ramos, Coyle, Strom: Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. in Nature immunology 2003 (PubMed)
    Show all 2 references for ABIN1098725

More Proteins for Hepatitis A Virus Cellular Receptor 2 Interaction Partners

Cow (Bovine) Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

  1. The Tim-3/Gal-9 (show LGALS9 Proteins) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

  1. Tim-3 blockade in combination with TLR activation induces the expression of antiviral molecules without a significant increase in TNF-alpha (show TNF Proteins) or SOCS1 (show SOCS1 Proteins).

  2. this study shows that the expression of TIM-3 is correlated with advanced stage and could be independent risk factors for colorectal cancer

  3. Immune checkpoint proteins are co-inhibitory factors that can diminish the antigen-specific immune responses by attenuating the regulatory role of cytotoxic T-lymphocyte-associated protein 4 (show CTLA4 Proteins), programmed cell death-1 (show PDCD1 Proteins), lymphocyte-activation gene 3 (show LAG3 Proteins), and T-cell immunoglobulin mucin-3.

  4. TLR2, Tim1 (show ARHGEF5 Proteins), Tim3, TNF-alpha (show TNF Proteins), IgE and EOS (show IKZF4 Proteins) play a role in Mycoplasma pneumoniae Pneumonia-related wheezing in children.

  5. The results of our study showed that there is no significant association between TIM-1 (show ARHGEF5 Proteins) 5383-5397ins/del and Multiple sclerosis (MS) (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS

  6. this study shoes that Tim-3 level is significantly upregulated in monocytes from gastric cancer patients compared with those from healthy controls

  7. these results suggest that TIM3 is a novel therapeutic target and prognostic biomarker for esophageal squamous cell carcinoma (ESCC) and promotes metastasis of ESCC by inducing epithelial-mesenchymal transition via, at least partially, the Akt (show AKT1 Proteins)/GSK-3beta/Snail (show SNAI1 Proteins) signaling pathway.

  8. Tim-3 facilitates osteosarcoma proliferation and metastasis through the NF-kappaB (show NFKB1 Proteins) pathway and epithelial-mesenchymal transition.

  9. Studied the associations of T-cell immunoglobulin and mucin (show SLC13A2 Proteins) domain-3 (Tim-3) polymorphisms and the alternate reading frame protein (F protein (show HPD Proteins)) with the outcomes of HCV infection; findings suggest that the rs12186731 CT and rs13170556 TC/CC genotypes of Tim-3 provide potential protective effects with the F protein (show HPD Proteins) in the outcomes of HCV infection and that these effects are related to sex and age.

  10. this study shows that the levels of expression of TIM-3 on CD4 (show CD4 Proteins)+ T cells, CD8 (show CD8A Proteins)+ T cells, CD56 (show NCAM1 Proteins)+ T cells and in serum in patients with systemic lupus erythematosus are significantly higher than those of healthy controls

Mouse (Murine) Hepatitis A Virus Cellular Receptor 2 (HAVCR2) interaction partners

  1. Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression.

  2. in mice, TIM-3 is not essential for development of HDM (show HDAC3 Proteins)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (show HDAC3 Proteins)-induced chronic allergic airway inflammation.

  3. Authors found that a CD8 (show CD8A Proteins)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.

  4. TIM4 (show TIMD4 Proteins) binds TIM3 on the surface of polarized Th1 (show HAND1 Proteins) cells to induce Th1 (show HAND1 Proteins) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.

  5. The Gal-9 (show LGALS9 Proteins)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.

  6. TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.

  7. Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN Proteins) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A Proteins) ligation.

  8. Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer

  9. TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.

  10. TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1 (show HIF1A Proteins)-dependent manner.

Hepatitis A Virus Cellular Receptor 2 (HAVCR2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

Alternative names and synonyms associated with Hepatitis A Virus Cellular Receptor 2 (HAVCR2)

  • hepatitis A virus cellular receptor 2 (HAVCR2)
  • hepatitis A virus cellular receptor 2 (Havcr2)
  • HAVcr-2 protein
  • HAVCR2 protein
  • KIM-3 protein
  • MGC140131 protein
  • TIM-3 protein
  • tim3 protein
  • TIMD-3 protein
  • Timd3 protein

Protein level used designations for HAVCR2

hepatitis A virus cellular receptor 2 , T cell immunoglobulin mucin 3 , T cell immunoglobulin mucin-3 , T-cell immunoglobulin and mucin domain-containing protein 3 , T-cell membrane protein 3 , kidney injury molecule-3 , HAVcr-2 , T-cell immunoglobulin and mucin domain containing 3 , TIMD-3 , hepatitis A virus cellular receptor 2 homolog , TIM-3

462219 Pan troglodytes
768047 Bos taurus
84868 Homo sapiens
171285 Mus musculus
363578 Rattus norvegicus
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