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the skNAC-Smyd1 (show SMYD1 Proteins) complex is involved in transcriptional regulation both via the control of histone methylation and histone (de)acetylation.
skNAC binds to the E3 SUMO ligase mammalian Mms21/Nse2 (show NSMCE2 Proteins) and that knockdown of Nse2 (show NSMCE2 Proteins) expression inhibits specific aspects of myogenic differentiation, accompanied by a partial blockade of the nuclear-to-cytoplasmic translocation of the skNAC-Smyd1 (show SMYD1 Proteins) complex
depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.
We propose that maximal transcriptional repression by FIAT (show TXLNG Proteins) requires its interaction with SUMOylated, HDAC2 (show HDAC2 Proteins)-interacting aNAC (show NACa2 Proteins)
Altered gene dosages for Galphas (show GNAS Proteins) and alpha- NAC in compound heterozygous mice result in reduced bone mass, increased numbers of osteocytes, and enhanced expression of Sost (show SOST Proteins).
The bone phenotype of compound Naca(+/-); Fiat (show TXLNG Proteins)(+/-) heterozygotes confirms that FIAT (show TXLNG Proteins) and alphaNAC are part of a common genetic pathway and support a role for the FIAT (show TXLNG Proteins)/alphaNAC interaction in normal bone physiology.
data suggest that skNAC controls myoblast migration and sarcomere architecture in a calpain-dependent manner
nascent polypeptide associated complex regulates specific aspects of myogenesis.
The muscle-specific (show EIF3K Proteins) transcription factor skNAC is the major binding partner for Smyd1 (show SMYD1 Proteins) in the developing heart.
Inhibition of alpha NAC nuclear translocation results in an osteopenic phenotype caused by reduced expression of osteocalcin (show BGLAP Proteins) and type I collagen, accelerated mineralization, and immature woven-bone formation.
Results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation.
Low NACA expression is associated with rhabdomyosarcoma.
[review] First evidence of a functional interaction between ATF4 (show ATF4 Proteins), FIAT (factor-inhibiting ATF4-mediated transcription (show TXLNG Proteins)) and alphaNAC (nascent polypeptide-associated complex and coactivator alpha).
NACA gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
identified a region in the NAC domain of the human NAC alpha-subunit (show POLG Proteins) as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit (show POLG Proteins)
Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.
a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen
virtual Northern blots to analyze expression of NACA and ANX2 (show ANXA2 Proteins) in progenitor cultures of nine children with Juvenile myelomonocytic leukemia and five healthy individuals
Altogether, these results characterize NACA as a new factor involved in the positive regulation of human erythroid-cell differentiation.
Alpha NAC downregulation in hypoxic cells or NAC ablation by NAC short-interfering RNA (siRNA) leads to the initiation of ER stress responses, which results in caspase (show CASP3 Proteins)-dependent apoptosis.
The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene.
alpha-NAC, muscle-specific form
, nascent polypeptide-associated complex alpha subunit
, nascent polypeptide-associated complex subunit alpha
, nascent polypeptide-associated complex subunit alpha, muscle-specific form
, no knack
, nascent-polypeptide-associated complex alpha polypeptide