Browse our anti-MBNL1 (MBNL1) Antibodies

Full name:
anti-Muscleblind-Like (Drosophila) Antibodies (MBNL1)
On www.antibodies-online.com are 107 Muscleblind-Like (Drosophila) (MBNL1) Antibodies from 15 different suppliers available. Additionally we are shipping MBNL1 Proteins (13) and and many more products for this protein. A total of 126 MBNL1 products are currently listed.
Synonyms:
EXP, EXP35, EXP40, EXP42, MBNL, MBNL1, mKIAA0428, zgc:153954
list all antibodies Gene Name GeneID UniProt
MBNL1 56758 Q9JKP5
MBNL1 4154 Q9NR56
MBNL1 282635  

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Most Popular Reactivities for anti-MBNL1 (MBNL1) Antibodies

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anti-Mouse (Murine) MBNL1 Antibodies:

anti-Human MBNL1 Antibodies:

anti-Rat (Rattus) MBNL1 Antibodies:

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Top referenced anti-MBNL1 Antibodies

  1. Human Polyclonal MBNL1 Primary Antibody for WB - ABIN1881533 : Sen, Talukdar, Liu, Tam, Reddy, Webster: Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for 1881533

  2. Human Polyclonal MBNL1 Primary Antibody for IHC, WB - ABIN2776698 : Adereth, Dammai, Kose, Li, Hsu: RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1. in Nature cell biology 2005 (PubMed)
    Show all 3 references for 2776698

  3. Human Polyclonal MBNL1 Primary Antibody for ELISA, WB - ABIN334433 : Warf, Berglund: MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T. in RNA (New York, N.Y.) 2007 (PubMed)

  4. Human Monoclonal MBNL1 Primary Antibody for IF, IHC (p) - ABIN561753 : Rehman, Gladman, Periasamy, Sun, Mahadevan: Development of an AP-FRET based analysis for characterizing RNA-protein interactions in myotonic dystrophy (DM1). in PLoS ONE 2014 (PubMed)

  5. Human Monoclonal MBNL1 Primary Antibody for ICC, IF - ABIN409393 : Mankodi, Teng-Umnuay, Krym, Henderson, Swanson, Thornton: Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2. in Annals of neurology 2003 (PubMed)

More Antibodies against MBNL1 Interaction Partners

Mouse (Murine) Muscleblind-Like (Drosophila) (MBNL1) interaction partners

  1. Data show that Muscleblind-like 1 (Mbnl1) and Muscleblind-Like 3 (Mbnl3 (show MBNL3 Antibodies)) bind skeletal muscle chloride channel (show CLCA1 Antibodies) CIC-1 (Clc-1 (show CLCN1 Antibodies)) mRNA.

  2. Depletion of Mbnl1 and/or Mbnl2 (show MBNL2 Antibodies) reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  3. Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  4. MBNL1 overexpression promotes transformation of fibroblasts into myofibroblasts.

  5. These data indicate that MBNL1 plays a conserved role in negatively regulating TGFbeta (show TGFB1 Antibodies) signaling, and is required for normal valve morphogenesis and homeostasis in vivo.

  6. this study supports a key role for Mbnl1 loss in the initiation of DM1 cardiac disease.

  7. Differential expression of Mbnl1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.

  8. Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.

  9. depletion of Mbnl proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  10. consistent with a central and negative regulatory role for MBNL proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

Human Muscleblind-Like (Drosophila) (MBNL1) interaction partners

  1. Binding of the MBNL zinc fingers to cardiac troponin T (show TNNT2 Antibodies) pre-mRNA is specific and relatively simple, unlike the complex multiple dimer-trimer stoichiometries postulated in some previous studies.

  2. Heterozygous missense mutations and one in-frame deletion in MBNL1 were identified in 3 myotonic dystrophy patients.

  3. Nuclear retention of full-length HTT (show HTT Antibodies) RNA is mediated by splicing factors MBNL1 and U2AF65 (show U2AF59 Antibodies)

  4. muscleblind-like 1 (MBNL1) is a robust suppressor of multiorgan breast cancer metastasis. It binds the 3' untranslated regions of DBNL (show DBNL Antibodies) and TACC1 (show TACC1 Antibodies) -two genes that are implicated as metastasis suppressors.

  5. Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  6. abnormal splicing of DMD (show DMD Antibodies) exon 78 found in dystrophic muscles of DM1 (show DMPK Antibodies) patients is due to the functional loss of MBNL1 and leads to the re-expression of an embryonic dystrophin (show DMD Antibodies) in place of the adult isoform.

  7. Reduced RBFOX1 (show A2BP1 Antibodies) activity in myotonic dystrophy type 1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1.

  8. MBNL1 binds with C allelic pre-miR (show MLXIP Antibodies)-1307 leading to low expression of miR (show MLXIP Antibodies)-1307-3p in colorectal cancer.

  9. The result is consistent with the hypothesis that MBNL proteins are trapped by expanded CUG repeats and inactivated in myotonic dystrophy type 1 (DM1) and that CELF1 is activated in DM1.

  10. Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.

MBNL1 Antigen Profile

Antigen Summary

Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA (By similarity).

Alternative names and synonyms associated with MBNL1

  • muscleblind-like (Drosophila) (MBNL1) antibody
  • muscleblind-like (Drosophila) (mbnl1) antibody
  • muscleblind-like 1 (Drosophila) (Mbnl1) antibody
  • muscleblind-like splicing regulator 1 (MBNL1) antibody
  • muscleblind-like splicing regulator 1 (Mbnl1) antibody
  • EXP antibody
  • EXP35 antibody
  • EXP40 antibody
  • EXP42 antibody
  • MBNL antibody
  • MBNL1 antibody
  • mKIAA0428 antibody
  • zgc:153954 antibody

Protein level used designations for MBNL1

muscleblind-like , muscleblind-like (Drosophila) , muscleblind-like protein 1 , muscleblind-like 1 , triplet-expansion RNA-binding protein

GENE ID SPECIES
100218825 Taeniopygia guttata
100559321 Anolis carolinensis
100583541 Nomascus leucogenys
767696 Danio rerio
425033 Gallus gallus
56758 Mus musculus
4154 Homo sapiens
477116 Canis lupus familiaris
781653 Bos taurus
282635 Rattus norvegicus
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