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SART1 has a role in IFN-mediated anti-Hepatitis B virus response
Data indicate that mutant VHL (show VHL Proteins) can protect HIF1alpha (show HIF1A Proteins) from SART1-dependent degradation in normoxic conditions, but this protection is lost in hypoxic settings, favoring hypoxia-dependent ccRCC proliferation.
SART1 exerts its anti-Hepatitis C virus action through direct transcriptional regulation for some Interferon (show IFNA Proteins) stimulating genes and alternative splicing for others.
This study identifies SART1 as a previously unidentified regulator of c-FLIP (show CFLAR Proteins) and drug-induced activation of caspase-8 (show CASP8 Proteins).
p110 (show CUX1 Proteins), a novel human U6 snRNP (show LSM2 Proteins) protein and U4/U6 snRNP (show LSM2 Proteins) recycling factor
hypothesize that polymorphic variation within the SART-1 gene may account for individuals developing atopy
hypoxia-associated factor (HAF (show F12 Proteins)), also known as SART1, a protein expressed in proliferating cells, binds and ubiquitinates HIF-1alpha (show HIF1A Proteins) in vitro, and both binding and E3 ligase activity are mediated by HAF (show F12 Proteins) amino acids 654 to 800
SART1(+/-) mice showed significant up-regulation of HIF-1alpha (show HIF1A Proteins) in circulating and liver-infiltrating immune cells
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation\; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
, squamous cell carcinoma antigen recognized by T cells
, U4/U6.U5 tri-snRNP-associated protein 1
, squamous-cell carcinoma T-cell-recognized antigen
, U4/U6.U5 tri-snRNP-associated protein 1-like
, u4/U6.U5 tri-snRNP-associated protein 1-like
, IgE autoantigen
, SART1(259) protein
, SART1(800) protein
, SNU66 homolog
, U4/U6.U5 tri-snRNP-associated 110 kDa protein
, small nuclear ribonucleoprotein 110kDa (U4/U6.U5)
, squamous cell carcinoma antigen recognised by T cells
, squamous cell carcinoma antigen recognized by T cells 1
, squamous cell carcinoma antigen recognized by T-cells 1
, hypoxia-associated factor