Browse our MTAP Proteins (MTAP)

Full name:
Methylthioadenosine phosphorylase Proteins (MTAP)
On www.antibodies-online.com are 17 Methylthioadenosine phosphorylase (MTAP) Proteins from 6 different suppliers available. Additionally we are shipping MTAP Antibodies (54) and MTAP Kits (11) and many more products for this protein. A total of 85 MTAP products are currently listed.
Synonyms:
1300019I21Rik, BDMF, c86fus, Cc1-6, DMSFH, DMSMFH, LGMBF, MSAP, MTAPase, zgc:66012
list all proteins Gene Name GeneID UniProt
MTAP 4507 Q13126
MTAP 66902 Q9CQ65
Rat MTAP MTAP 298227  

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MTAP Proteins (MTAP) by Origin

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Top referenced MTAP Proteins

  1. Human MTAP Protein expressed in Wheat germ - ABIN1311524 : Yang, Gee, Gee, Zurita-Lopez, Khare, Clarke, Mamula: Lupus autoimmunity altered by cellular methylation metabolism. in Autoimmunity 2013 (PubMed)

More Proteins for MTAP Interaction Partners

Human Methylthioadenosine phosphorylase (MTAP) interaction partners

  1. The SNP rs7023954 of methylthioadenosine phosphorylase co-dominantly expressed alleles revealed no difference in the conversion rate of 5'-methylthioadenosine to adenine and 5-methylthioribose-1-phosphate, indicating that this known enzymatic activity does not modulate the tumor suppressive function of methylthioadenosine phosphorylase.

  2. Data demonstrate that MTAP deficiency leads to accumulation of MTA (show DNMT1 Proteins) inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver.

  3. methionine adenosyltransferase II alpha (MAT2A (show MAT2A Proteins)), and the arginine methyltransferase, PRMT5 (show PRMT5 Proteins), as vulnerable enzymes in cells with MTAP deletion.

  4. MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors.

  5. study to describe MTAP expression in a series of Pilocytic astrocytomas and relate it to the clinicopathological features of the patients; found MTAP expression is retained in Pilocytic astrocytomas and is not an outcome predictor for these tumors

  6. MTAP deficiency was predictive of worse disease-specific survival and distant metastasis-free survival, suggesting its role in disease progression and as an independent prognostic biomarker of nasopharyngeal carcinoma

  7. In the MTAP-deficient cases, the homozygous deletion of MTAP predicted adverse outcome. In MTAP-deficient cells, MTAP reexpression inhibited cell migration and invasion, proliferation and anchorage-independent colony formation and downregulated cyclin D1 (show CCND1 Proteins).

  8. MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients.

  9. MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB (show NFKB1 Proteins) activation and apoptosis in hepatic stellate cells.

  10. SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD.

Mouse (Murine) Methylthioadenosine phosphorylase (MTAP) interaction partners

  1. Data demonstrate that MTAP deficiency leads to accumulation of MTA (show DNMT1 Proteins) inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver.

  2. MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB (show NFKB1 Proteins) activation and apoptosis in hepatic stellate cells.

  3. Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver

  4. Studies show that Mtap is a tumor suppressor gene independent of CDKN2A and ARF.

MTAP Protein Profile

Protein Summary

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.

Alternative names and synonyms associated with MTAP

  • methylthioadenosine phosphorylase (mtaP)
  • methylthioadenosine phosphorylase (Mmah_0779)
  • methylthioadenosine phosphorylase (Mmah_0844)
  • methylthioadenosine phosphorylase (Tagg_1015)
  • methylthioadenosine phosphorylase (Slip_0897)
  • methylthioadenosine phosphorylase (Slip_1284)
  • methylthioadenosine phosphorylase (Toce_0364)
  • methylthioadenosine phosphorylase (Vdis_0648)
  • methylthioadenosine phosphorylase (Mfer_0491)
  • methylthioadenosine phosphorylase (Intca_0886)
  • methylthioadenosine phosphorylase (Desmu_1057)
  • methylthioadenosine phosphorylase (Dester_1490)
  • methylthioadenosine phosphorylase (Arcve_1093)
  • methylthioadenosine phosphorylase (Mahau_1873)
  • methylthioadenosine phosphorylase (Mzhil_0273)
  • methylthioadenosine phosphorylase (MTAP)
  • methylthioadenosine phosphorylase (Mtap)
  • methylthioadenosine phosphorylase (mtap)
  • 1300019I21Rik protein
  • BDMF protein
  • c86fus protein
  • Cc1-6 protein
  • DMSFH protein
  • DMSMFH protein
  • LGMBF protein
  • MSAP protein
  • MTAPase protein
  • zgc:66012 protein

Protein level used designations for MTAP

methylthioadenosine phosphorylase , 5'-methylthioadenosine phosphorylase , MTA phosphorylase , MTAPase , MeSAdo phosphorylase , S-methyl-5'-thioadenosine phosphorylase , CG4802-like

GENE ID SPECIES
3230190 Dehalococcoides ethenogenes 195
8982941 Methanohalophilus mahii DSM 5219
8983006 Methanohalophilus mahii DSM 5219
9166038 Thermosphaera aggregans DSM 11486
9273683 Syntrophothermus lipocalidus DSM 12680
9274073 Syntrophothermus lipocalidus DSM 12680
9509999 Thermosediminibacter oceani DSM 16646
9751569 Vulcanisaeta distributa DSM 14429
9962213 Methanothermus fervidus DSM 2088
10083682 Intrasporangium calvum DSM 43043
10153764 Desulfurococcus mucosus DSM 2162
10270747 Desulfurobacterium thermolithotrophum DSM 11699
10394208 Archaeoglobus veneficus SNP6
10608635 Mahella australiensis 50-1 BON
10821877 Methanosalsum zhilinae DSM 4017
4507 Homo sapiens
66902 Mus musculus
298227 Rattus norvegicus
709020 Macaca mulatta
782907 Bos taurus
393526 Danio rerio
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